{"id":114523,"date":"2026-06-15T09:12:17","date_gmt":"2026-06-15T08:12:17","guid":{"rendered":"https:\/\/www.iispv.cat\/?p=114523"},"modified":"2026-06-15T09:15:51","modified_gmt":"2026-06-15T08:15:51","slug":"a-study-identifies-a-key-mechanism-in-the-way-that-the-liver-processes-the-fasting-and-nutricion","status":"publish","type":"post","link":"https:\/\/www.irbcatsud.cat\/en\/a-study-identifies-a-key-mechanism-in-the-way-that-the-liver-processes-the-fasting-and-nutricion\/","title":{"rendered":"A study identifies a key mechanism in the way that the liver processes the fasting and nutricion"},"content":{"rendered":"

A study identifies a key mechanism in the way that the liver processes the acute and fat, which has direct implications in diseases such as diabetes, obesity and metabolic liver disease. Understanding the role of this mechanism, which exercises as a key \u201csensor\u201d during the transition from aid to food, and doing it from a physiologic point of view, could open new therapeutic pathways to improve the control of glucose and body capacity to adapt to changes between aid and food. This is especially relevant in diseases such as those described above, since the horse loses precisely this capacity. The study promoted by the IRB CatSud, formerly IISPV) and led by researchers from the area of Diabetes and Associated Metabolic Diseases (CIBERDEM), has been published in the scientific journal Science Advances<\/em> with the title SUCNR1 coordinates metabolic flux, mitochondrial function, and nutrient-dependent adaptation in hepatocytes<\/em>. Researchers from various areas of the Consorcio Centro de Investigaci\u00f3n Biom\u00e9dica en Red) (CIBER) of the Instituto\u00a0 de Salud Carlos III (ISCIII) and the Universitat Rovira i Virgili (URV), have participated in the study.<\/p>\n

The Diabetes and Associated Metabolic Diseases (DIAMET) research group at IRB CatSud is responsible for the study that provides relevant knowledge to advance in the prevention and treatment of high-impact metabolic disorders in public health in the long term. The research team has focused on succinate, which apart from serving to obtain energy, also acts as a signal in other cells through a receptor called SUCNR1. This receptor is especially abundant in a specific area of the hygro and increases during the development of this organ, which suggests an important role in liver function.<\/p>\n

In addition, the research staff has discovered that both the levels of succino and the expression of the SUCNR1 receptor in the liver varied depending on whether the organism is in aid or fed. To better understand their role, the researchers involved studied mice that lack this receptor in the main cells of the hygda (the hepatocytes). In the absence of this receptor, the liver “is active in excess” and ends up producing more glucose than necessary in conditions of aid. This is accompanied by a lower capacity of the organism to adapt correctly to the changes that derive from the nutritional state, that is, in aid or after eating. At the cellular level, the lack of this receptor alters the way in which the water cells use glucose to produce energy, which causes the dependence of other nutrients and alters their functionality. Consequently, in response to the intake, an incomplete recovery of the energy reserves of the cells is observed.<\/p>\n

Together, these results identify the SUCNR1 regulator as essential in the metabolic adaptation of the water, connecting energy signals with the capacity of cells to adjust to nutritional changes.<\/p>\n

The study involved the participation of other research centres and universities, such as the Centro Singular de Investigaci\u00f3n en Medicina Molecular y Enfermedades Cr\u00f3nicas (CIMUS),\u00a0Universidad de Santiago de Compostela, the Institut de Recerca Biom\u00e8dica Barcelona (IRB Barcelona), the Universitat de Barcelona (UB), the Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), the Institut de Recerca Sant Pau, the Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), the University of Bern and the Bern University Hospital. Also have participated reseachers of the CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN) and CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD).<\/p>\n

Bibliographic reference<\/strong><\/p>\n

Marsal-Beltran, A., Salmer\u00f3n-Pelado, L., Ribas-Latre, A., Repoll\u00e9s-de-Dalmau, M., Rodr\u00edguez-Pe\u00f1a, M. M., N\u00fa\u00f1ez-Roa, C., Badia, J., Madeira, A., Novoa, E., Beltr\u00e0, M., Plata-G\u00f3mez, A. B., Capellades, J., Escol\u00e0-Gil, J. C., Zorzano, A., Yanes, \u00d3., Efeyan, A., Nogueiras, R., Gracia-Sancho, J., Vendrell, J., Ceperuelo-Mallafr\u00e9, V., \u2026 Fern\u00e1ndez-Veledo, S. (2026). SUCNR1 coordinates metabolic flux, mitochondrial function, and nutrient-dependent adaptation in hepatocytes.\u00a0Science advances<\/em>,\u00a012<\/em>(24), eaec8873. https:\/\/doi.org\/10.1126\/sciadv.aec8873<\/a><\/p>\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

A study identifies a key mechanism in the way that the liver processes the acute and fat, which has direct implications in diseases such as diabetes, obesity and metabolic liver disease. Understanding the role of this mechanism, which exercises as a key \u201csensor\u201d during the transition from aid to food, and doing it from a […]<\/p>\n","protected":false},"author":36,"featured_media":114519,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1883,1026,1831,1478,1479],"tags":[3010,3011,2703,2359,3013,2804,3014,3012,2959],"class_list":["post-114523","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualitat-en","category-noticies-iispv-en","category-press-releases","category-publicacions-en","category-recerca-en","tag-ciber-en-2","tag-ciberdem-en","tag-diabetes-en","tag-diamet-en","tag-fasting","tag-irb-catsud-en","tag-liver","tag-metabolic-disease","tag-obesity"],"_links":{"self":[{"href":"https:\/\/www.irbcatsud.cat\/en\/wp-json\/wp\/v2\/posts\/114523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.irbcatsud.cat\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.irbcatsud.cat\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.irbcatsud.cat\/en\/wp-json\/wp\/v2\/users\/36"}],"replies":[{"embeddable":true,"href":"https:\/\/www.irbcatsud.cat\/en\/wp-json\/wp\/v2\/comments?post=114523"}],"version-history":[{"count":2,"href":"https:\/\/www.irbcatsud.cat\/en\/wp-json\/wp\/v2\/posts\/114523\/revisions"}],"predecessor-version":[{"id":114535,"href":"https:\/\/www.irbcatsud.cat\/en\/wp-json\/wp\/v2\/posts\/114523\/revisions\/114535"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.irbcatsud.cat\/en\/wp-json\/wp\/v2\/media\/114519"}],"wp:attachment":[{"href":"https:\/\/www.irbcatsud.cat\/en\/wp-json\/wp\/v2\/media?parent=114523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.irbcatsud.cat\/en\/wp-json\/wp\/v2\/categories?post=114523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.irbcatsud.cat\/en\/wp-json\/wp\/v2\/tags?post=114523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}