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Research in Neurobehavior and Health (NEUROLAB)

NEUROSCIENCES AND MENTAL HEALTH
GENETIC FACTORS PSYCHIATRIC DISEASES MENTAL DISORDER INTELLECTUAL DISABILITY NEUROMUSCULAR DISEASES CELLULAR NEUROBIOLOGY
OBJECTIUS

Advancing the understanding of the neurobiological mechanisms involved in the development, deterioration and recovery of the nervous system through clinical and preclinical models, with the aim of improving intervention, prevention and treatment strategies for neurological, psychiatric and painful disorders.

It is about contributing to the improvement of public health through the development of new strategies for prevention, diagnosis and treatment of neurological, psychiatric and pain disorders, generating applicable knowledge that can reduce the social, economic and health burden associated with these pathologies.

Specific objectives

Analyse the mechanisms of neurotoxicity and their effects on developmental disorders and neurodegenerative processes in preclinical models, in order to identify therapeutic targets and biomarkers.

Evaluate the effectiveness of early probiotic interventions in preclinical models, examining their effects on neuromotor maturation and the prevention of behavioural and cognitive deficits.

To study the psychobiological and psychopharmacological effects of psychedelic substances and other compounds of interest, as well as their therapeutic potential in the treatment of addictive disorders in animal models.

Identify and characterize altered inhibitory neuronal circuits in preclinical ALS models, with the aim of better understanding motor dysfunction and exploring possible intervention pathways.

Identify environmental factors that contribute to the development of myofascial pain in preclinical models, to establish correlations between environmental exposures and vulnerability to pain.

Determine the morphofunctional changes associated with different therapeutic interventions aimed at reducing myofascial pain, evaluating its effectiveness and mechanisms of action in preclinical models.

To explore the effects of transcranial stimulation by direct electric current (tDCS) on post-stroke rehabilitation, analyzing its impact on neuronal plasticity and functional recovery.

Promote the transfer and dissemination of the knowledge generated through scientific publications, participation in congresses, dissemination activities and interdisciplinary collaborations, facilitating that the results of the research reach the scientific community, health professionals, policy makers and society in general.

RESPONSABLES

  • Maria Teresa Colomina

  • Presentation
  • Research lines
  • Members
  • Competitive projects
  • Articles
  • SUPERVISED THESES
  • Neurotoxicology, developmental disorders, and neurodegeneration in preclinical models
  • Effects of early probiotic interventions in preclinical models
  • Psychobiology and psychopharmacology of behavior: study of psychedelics and treatment of addictive disorders
  • Identification and characterization of inhibitory circuits in preclinical models of ALS
  • Research in myofascial pain: identification of environmental factors that contribute to the development of myofascial pain in preclinical models
  • Myofascial pain research: morphofunctional evidence of the effects of therapeutic interventions aimed at reducing myofascial pain in preclinical models
  • Direct current transcranial stimulation in stroke rehabilitation

  • Title: Recerca en el dolor miofascialSEGURIDAD E IMPACTO NEUROCONDUCTUAL DE LA EXPOSICION A PROBIOTICOS EN EL PERIODO POSTNATAL Y DURANTE EL ENVEJECIMIENTO: EFECTOS Y MECANISMOS DE ACCION

    Principal Investigator: Maria Teresa Colmina

    Collaborating Researchers: Jordi Blanco; Maria Cabre; Manel Santafé; Rocio Rodulfo; Séfora Barberá; Raquel Gabaldón

    Reference number: PID2024-158713OB-C32

    Import: 100.000

    Start date: 2025

    Completion date: 2028

    Funding organization: Ministerio de Ciencia e Innovación

  • Title: Interneurons in ALS: shedding light. Scottish Universities Life Sciences Alliance (UK)

    Principal Investigator: Santiago Mora Parada

    Collaborating Researchers: Ilary Allodi

    Reference number: –

    Import: £9500 (=10789,81€)

    Start date: 1/03/2025

    Completion date: 31/12/2025

    Funding organization: RS MacDonald Facility Access Funding. University of St. Andrews (Scotland).

  • Title: Contaminacion atmosferica y salud mental ¿como influyen los contaminantes ambientales, y el genotipo apoe en el cerebro inmaduro y viejo? (I-NSPIRA)

    Principal Investigator: Maria Teresa Colmina

    Collaborating Researchers: Maria Cabre; Manel Santafé; Rocio Rodulfo; Séfora Barberá; Raquel Gabaldón

    Reference number: PID2020-113812RB-C31

    Import: 100.000

    Start date: 2022

    Completion date: 2026

    Funding organization: Ministerio de Ciencia e Innovació (España)

  • Title: RECERCA DE L’US D’ADHESIUS BIOCOMPATIBLES PER SUTURA I REPARACIÓ DE NERVIS (GLUENERVE)

    Principal Investigator: Maria Teresa Colmina

    Collaborating Researchers: Manuel Santafé; Maria Cabré; Jordi Blanco

    Reference number: ACE053/22/000071

    Import: 81.331,71

    Start date: 2022

    Completion date: 2025

    Funding organization: Generalitat de Catalunya. Projectes de recerca industrial i desenvolupament experimental entre empreses catalanes i desenvolupadors de tecnologia acreditats TECNIO (projectes INNOTEC)

    Published in the last five years

  • Guardia-Escote, L., Biosca-Brull, J., Blanco, J., Cabré, M., Basaure, P., Pérez-Fernández, C., Sánchez-Santed, F., Domingo, J. L., & Colomina, M. T. (2025). Impact of a high-fat diet on spatial learning and memory: The role of sex, APOE genotype, and postnatal chlorpyrifos exposure. Neurotoxicology, 110, 42–52. https://doi.org/10.1016/j.neuro.2025.07.004

  • Cativiela-Campos, B., Ruiz-Sobremazas, D., Rodulfo-Cárdenas, R., Barrasa, A., Sánchez-Santed, F., Colomina, M. T., Aschner, M., & López-Granero, C. (2025). What are the consequences of PM air pollution exposure on elderly behavior? A systematic review. Environmental pollution (Barking, Essex : 1987), 375, 126279. https://doi.org/10.1016/j.envpol.2025.126279

  • Ruiz-Sobremazas, D., Coca, M., Morales-Navas, M., Rodulfo-Cardenas, R., Lopez-Granero, C., Colomina, M. T., Perez-Fernandez, C., & Sanchez-Santed, F. (2025). The effects of oral gestational particulate matter 10 exposure: Insights into neurodevelopmental milestones, inhibitory control, adult sociability, and object recognition. Neurotoxicology, 108, 231–245. https://doi.org/10.1016/j.neuro.2025.04.007

  • Morales-Navas, M., Perez-Fernandez, C., Castaño-Castaño, S., Sánchez-Gil, A., Colomina, M. T., Leinekugel, X., & Sánchez-Santed, F. (2025). Sociability: Comparing the Effect of Chlorpyrifos with Valproic Acid. Journal of autism and developmental disorders, 55(3), 1101–1111. https://doi.org/10.1007/s10803-024-06263-z

  • Rodulfo-Cárdenas, R., Ruiz-Sobremazas, D., Biosca-Brull, J., Cabré, M., Blanco, J., López-Granero, C., Sánchez-Santed, F., & Colomina, M. T. (2023). The influence of environmental particulate matter exposure during late gestation and early life on the risk of neurodevelopmental disorders: A systematic review of experimental evidences. Environmental research, 236(Pt 1), 116792. https://doi.org/10.1016/j.envres.2023.116792

  • Biosca-Brull, J., Ona, G., Alarcón-Franco, L., & Colomina, M. T. (2024). A transcriptomic analysis in mice following a single dose of ibogaine identifies new potential therapeutic targets. Translational psychiatry, 14(1), 41. https://doi.org/10.1038/s41398-024-02773-7

  • Ruiz-Sobremazas, D., Ruiz Coca, M., Morales-Navas, M., Rodulfo-Cárdenas, R., López-Granero, C., Colomina, M. T., Perez-Fernandez, C., & Sanchez-Santed, F. (2024). Neurodevelopmental consequences of gestational exposure to particulate matter 10: Ultrasonic vocalizations and gene expression analysis using a bayesian approach. Environmental research, 240(Pt 1), 117487. https://doi.org/10.1016/j.envres.2023.117487

  • Corominas-Teruel, X., Bracco, M., Fibla, M., Segundo, R. M. S., Villalobos-Llaó, M., Gallea, C., Beranger, B., Toba, M., Valero-Cabré, A., & Colomina, M. T. (2023). High-density transcranial direct current stimulation to improve upper limb motor function following stroke: study protocol for a double-blind randomized clinical trial targeting prefrontal and/or cerebellar cognitive contributions to voluntary motion. Trials, 24(1), 783. https://doi.org/10.1186/s13063-023-07680-8

  • Ona, G., Reverte, I., Rossi, G. N., Dos Santos, R. G., Hallak, J. E., Colomina, M. T., & Bouso, J. C. (2023). Main targets of ibogaine and noribogaine associated with its putative anti-addictive effects: A mechanistic overview. Journal of psychopharmacology (Oxford, England), 37(12), 1190–1200. https://doi.org/10.1177/02698811231200882

  • Biosca-Brull, J., Basaure, P., Guardia-Escote, L., Cabré, M., Blanco, J., Morales-Navas, M., Sánchez-Santed, F., & Colomina, M. T. (2023). Environmental exposure to chlorpyrifos during gestation, APOE polymorphism and the risk on autistic-like behaviors. Environmental research, 237(Pt 2), 116969. https://doi.org/10.1016/j.envres.2023.116969

  • Ruiz-Sobremazas, D., Rodulfo-Cárdenas, R., Ruiz-Coca, M., Morales-Navas, M., Teresa Colomina, M., López-Granero, C., Sánchez-Santed, F., & Perez-Fernandez, C. (2023). Uncovering the link between air pollution and neurodevelopmental alterations during pregnancy and early life exposure: A systematic review. Neuroscience and biobehavioral reviews, 152, 105314. https://doi.org/10.1016/j.neubiorev.2023.105314

  • Guardia-Escote, L., Biosca-Brull, J., Cabré, M., Blanco, J., Mladenova-Koleva, M., Basaure, P., Pérez-Fernández, C., Sánchez-Santed, F., Domingo, J. L., & Colomina, M. T. (2023). Developmental brain lipidomics is influenced by postnatal chlorpyrifos exposure and APOE genetic background in mice. Archives of toxicology, 97(9), 2463–2475. https://doi.org/10.1007/s00204-023-03555-8

  • Biosca-Brull, J., Guardia-Escote, L., Basaure, P., Cabré, M., Blanco, J., Pérez-Fernández, C., Sánchez-Santed, F., Domingo, J. L., & Colomina, M. T. (2023). Exposure to chlorpyrifos during pregnancy differentially affects social behavior and GABA signaling elements in an APOE- and sex-dependent manner in a transgenic mouse model. Environmental research, 224, 115461. https://doi.org/10.1016/j.envres.2023.115461

  • Monclús, P., Bosque, M., Margalef, R., Colomina, M. T., Valderrama-Canales, F. J., Just, L., & Santafé, M. M. (2023). Shock waves as treatment of mouse myofascial trigger points. Pain practice : the official journal of World Institute of Pain, 23(7), 724–733. https://doi.org/10.1111/papr.13237

  • Mora, S., Stuckert, A., von Huth Friis, R., Pietersz, K., Noes-Holt, G., Montañana-Rosell, R., Wang, H., Sørensen, A. T., Selvan, R., Verhaagen, J., & Allodi, I. (2024). Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS. Nature communications, 15(1), 4867. https://doi.org/10.1038/s41467-024-48925-7

  • Title: Novel insights on the impact of very weak and conventional electric and magnetic fields by transcranial neuromodulation technologies: from low level neurophysiological effects to the rehabilitation of stroke patient

    Ph.D. candidate’s name: Xavier Coromines Teruel

    Year of defense: 2025

    University: URV

  • Title: bogaine for the treatment of opioid dependence: From mechanisms of action to clinical efficacy

    Ph.D. candidate’s name: Genis Oña Esteve

    Year of defense: 2024

    University: URV

  • Title: Influence of prenatal chlorpyrifos exposure, apoe genotype And sex on neurodevelopmental disorders: behavioral and Biochemical abnormalities in mice

    Ph.D. candidate’s name: Judit Biosca Brull

    Year of defense: 2023

    University: URV

  • Title: Dispositius digitals com a eina terapèutica en infants i Adolescents amb discapacitat intel·lectual. 2022

    Ph.D. candidate’s name: Marta Torra

    Year of defense: 2022

    University: URV

  • Title: Postnatal chlorpyrifos exposure influences the gut microbiota and the expression of biological and neurobehavioral characteristics of The Apoe Genotype in an age-dependent manne

    Ph.D. candidate’s name: Laia Guardia Escoté

    Year of defense: 2019

    University: URV

  • Title: Influencia del genotipo APOE en la expresión de efectos neuroconductuales derivados de la exposición postnatal a clorpirifós 2014-2017. Score: Apto cum laude

    Ph.D. candidate’s name: Pia Isabel Basaure Garcia

    Year of defense: 2017

    University: URV

  • Title: ApoE phenotype expression and its modulation by chlorpyrifos: new insightsinto gene-toxic interactions

    Ph.D. candidate’s name: Fiona Peris Sampedro

    Year of defense: 2016

    University: URV

Membres De L’equip

  • Investigator

    • Maria Cabré Bargalló
    • Jordi Blanco
    • Manuel Santafé Martínez
    • Santiago Mora Parada
    • Judit Biosca Brull
    • Rocío Rodulfo Cardenas
    • Séfora Barberà Parada
    • Raquel Gabaldón

  • Clinical investigator

    • Montserrat Fibla Simó
    • Rosa Maria Sansegundo Mozo
    • Joan Ramón Margalef
    • Genís Oña Esteve

  • Part-time researchers

    • Marc Bosque

Altres grups de Neurosciences and Mental Health

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