OBJECTIUS

El grup de recerca en Diabetis i Malalties Metabòliques Associades (DIAMET) és un grup de recerca multidisciplinari i dinàmic centrat en l’estudi dels trastorns metabòlics associats a la morbiditat de la diabetis mellitus i l’obesitat. El grup de recerca està liderat per la doctora Sonia Fernandez-Veledo i el doctor Joan Vendrell i està integrat per investigadors clínics i bàsics, tècnics i personal de suport administratiu.

Combinem la recerca bàsica i clínica per integrar els coneixements de totes dues àrees i aconseguir resultats amb un alt nivell de translacionalitat. Tots els nostres esforços estan centrats en aportar noves pistes per delinear les bases patogèniques subjacents a l’obesitat i als trastorns metabòlics associats, amb l’objectiu d’identificar noves dianes terapèutiques per al tractament d’aquestes patologies. Explorem els esdeveniments moleculars implicats en la comunicació entre òrgans que participen en la regulació dels nutrients, incloent el teixit adipós, el fetge, el pàncrees, l’intestí i el cervell.

RESPONSABLES
  • Dra. Sonia Fernández-Veledo

  • Dr. Joan Josep Vendrell Ortega

  • Presentació
  • Línies de recerca
  • Projectes
  • Membres del grup
  • Transferència
  • Difusió
  • Publicacions
  • Contacte

El grup pertany a l’Institut de Recerca Biomèdica Catalunya Sud (IRB CatSud) i a l’Hospital Universitari de Tarragona Joan XXIII (HJ23) i està integrat en una xarxa nacional d’estudi de la diabetis CIBERdem, iniciada el 2008 per l’Institut de Salut Carlos III. Així mateix, el grup és reconegut des del 2009 com a grup consolidat per l’Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) de la Generalitat de Catalunya – Universitat Rovira i Virgili.

DIAMET compta amb una àmplia experiència en la formació d’estudiants de grau, estudiants de postgrau i formació post doctoral, tant en ciències clíniques com bàsiques. El grup integra investigadors de diferents programes de prestigi competitius com ara Miguel Servet i Ramón i Cajal, ajuts post doctorals juniors (Sara Borrell i Juan de la Cierva) i contractes de formació especialitzada en salut de Río Hortega. A més, el grup ha establert programes de formació de beques en laboratoris estrangers de prestigiosos grups de recerca a Europa i EUA.

  • Metabòlits senyalitzadors com a elements crítics en la comunicació metabòlica entre òrgans. Busquem nous sensors metabòlics i dianes terapèutiques per a l’obesitat, la diabetis tipus 2 (DT2), l’esteatosi hepàtica no alcohòlica (NAFLD), el càncer i l’aterosclerosi.
  • Paper de les cèl·lules mare derivades del teixit adipós i de la fracció no adipocitària del teixit adipós en la fisiopatologia de l’obesitat i la DT2.
  • Impacte de les alteracions metabòliques de la diabetis gestacional en la comunicació feto-materna.
  • Modulació del microbiota intestinal per gestionar l’obesitat i les seves comorbiditats.
  • Respostes immunometabòliques a les intervencions dietètiques.
  • Eines clíniques i biomarcadors per a la detecció precoç de la disfunció metabòlica.

  • DTS23/00031. Nuevos péptidos bloqueantes para el tratamiento del hígado graso no alcohólico. ISCIII. Funding: 136.730€ (2023-2026) PI: S. Fernández Veledo.

  • 101114086. Valorisation and Optimization of novel first-in-class succinate-depleting therapies. European Innovation Ecosystems work programme of Horizon Europe, EISMEA. WomenTech_EU. Funding: 75.000€. (2023-2024). Scientific PI: S. Fernández Veledo.

  • PDC2022-133164-I00. Desarrollo de un nuevo producto biofarmaceutica para el tratamiento de enfermedades metabólicas associades a la obesidad. Prueba de Concepto, Agencia Estatal de Investigación. Funding: 149.500€ (2022– 2024). PI: S. Fernández Veledo.

  • 2021 INNOV 00033. Succinate-SUCNR1 axis, a central but unexploited target for obesity-related disorder. AGAUR AJUT INNOVADORS. Funding: 84.000€ (2022– 2024). PI: S. Fernández Veledo.

  • IU68-018623. 2019 INNOV 00008.New probiotic strategies for obesity-related disorders and  development of the companion diagnostic kit. AGAUR AJUT INNOVADORS. Funding: 84.000€ (2020–2022). PI: S. Fernández Veledo.

  • IU68-017106. Nuevas Estrategias probióticas para la obesidad y desarrollo de su kit diagnóstico. AGAUR AJUT PRODUCTE. Funding: 99.975€ (2020-2021). PI: S. Fernández Veledo.

  • SUCCIPRO. A new probiotic strategy to improve metabolic and inflammatory profile in obese patients. Caixaimpulse. Fundación la Caixa. Funding: 70.000€ (2019-2021). Scientific PI: S. Fernández-Veledo.

    Succipro, created in 2022, is a spin-off from the Pere i Virgili Health Research Institute (IISPV) and the Rovira i Virgili University, dedicated to creating innovative pharmaceutical solutions for the treatment of inflammatory and metabolic diseases. They work to transform pioneering scientific discoveries into therapies that improve the quality of life for patients.

  • DTS19/00040. New probiotic strategies for obesity-related disturbances and its companion diagnostic. Instituto de salut Carlos III. Funding: 115.500€ (2019-2021). PI: S. Fernández Veledo.

  • PID2021-122480OB-100. SUC-LIVE. Succinate/SUCNR1 axis in liver. From the physiology to NAFLD progression: basic and clinical approach. Spanish Ministry of Science and Innovation. Funding: 299.200€ (2022-2025) PI: S. Fernández Veledo.

  • PI23/01133. The usefulness of circulating microvesicles (host and bacterial) in regulating metabolic homeostasis in obesity Randomized study of parallel arms in obese patients undergoing caloric restriction diet vs.early time-restricted eating. Instituto de Salud Carlos III. Vendrell J. 2024-2026. 172.500 €. Principal investigator.

  • PI23/01230. Circulating extracellular vesicles as key regulators of the interplay between gut microbiota and host metabolism: Preclinical studies in obese mice undergoing dietary interventions and mechanistic studies. Instituto de Salud Carlos III. Ceperuelo-Mallafré, V. 2023-2026. 166.250 €. Co-ordinator.

  • PI23/01289. Role of circulating extracellular vesicles (host and bacterial) in the homeostasis balance after bariatric surgery in morbidly obese patients. Analysis as biomarkers of weight loss effectiveness and diabetes remission in three cohorts. Instituto de Salud Carlos III. Pellitero, S. 2023- 2026. 128.750 €. Co-ordinator.

  • PI23/00071. The role of circulating extracellular vesicles (host and bacterial) on metabolic homeostasis and as interorgan communicators in patients with type 1 diabetes and non-alcoholic fatty liver disease. Instituto de Salud Carlos III. Llauradó, G. 2023-2026. 114.375 €. Co-ordinator.

  • NEURO_DIA. NEUROinflammatory role of the succinate/SUCNR1 axis in obesity-related DIAbetes. European Foundation for the Study of Diabetes (EFSD). Funding: 100.000€ (2022-2024) PI: S. Fernández Veledo.

  • META_NEURO. Metabolic control of smoldering neuroinflammation. RFA-2203-39318- National Multiple Sclerosis Society – University of Cambridge. Funding: 599.422 €. (2023-2024) Reseach team member. PI: Luca Peruzzotti-Jametti

  • HR20-00051. METASUCC. Succinate/SUCNR1 axis: a novel target for anti-obesity therapies. La Caixa Foundation. Funding: 998.903€ (2020-2023). Coordinator and PI: S. Fernández Veledo.

  • RTI2018-093919-B-I00. Succinate as a new extracellular signling metabolite governing glucose homeostasis: SUCNR1, a molecular drug target in obesity and related diseases. Spanish Ministry of Science and Innovation. Funding: 205.700€ (2019-2021). PI: S. Fernández Veledo.

  • Using indicators to influence consumer behaviour and prevent pre-disease through food and lifestyle related interventions. Food4Health. EIT Health and EIT Food. Funding: 30.000€ (2019-2020). Reseach team member. PI: Joan Vendrell

  • 225/C/2016. Mechanisms responsible for the defective differentiation capacity of adipose-derived stem cells in obesity: Identification of new regulators amenable for the development of innovative. La Marató de TV3 Foundation. Funding: 150.000€ (2017-2019). PI: S. Fernández Veledo.

  • SAF2015-65019R. Understanding the Pathophysiological Significance of Succinate/SUCNR1 Axis in Obesity and Type 2 Diabetes: A Translational Approach. Spanish Ministry of Economy and Competitiveness. Funding: 162.900€ (2016-2018). PI: S. Fernández Veledo.

  • Central effects of GLP2-R activation: insights into a potential brain-gut-adipose tissue cross- talk. European Foundation for the Study of Diabetes (EFSD). Funding: 50.000€ (2015-2016). PI: S. Fernández Veledo.

  • PIE14/00045. INFLAMES. Identification of novel modulators of chronic inflammation in prevalent diseases: unveiling divergent mechanisms of disease. ISCIII. Funding: 679.800€ (2014-2017). Type of participation: Research team member; Coordinator: Antonio Zorzano.

  • SAF2012-36186. Función del metabolismo del glucógeno en el tejido adiposo: investigación translacional para la búsqueda de nuevas dianas terapéuticas en el tratamiento de la obesidad. Spanish Ministry of Economy and Competitiveness. Funding: 128.700€ (2013-2015). PI: S. Fernández Veledo.

  • Title: PID2021-122480OB-I00-Subv: Eje Succinado/ SUCNR1 en el hígado de la fisiología a la progresión de la EHGNA: Enfoque básico y clínico

    Funding entity: Ministerio de Ciencia, Innovación y Universidades

    Duration: 2022-2025

    Principal Investigator: Sonia Fernández-Veledo, Phd

  • Title: NEUROinflammatory role of the succinate/SUCNR1 axis in obesity-related DIAbetes (NEURO_DIA)

    Funding entity: European Foundation for the Study Of Diabetes

    Duration: 2022-2025

    Principal Investigator: Sonia Fernández-Veledo, Phd

  • Title: PID2020-119030RJ-I00: Succinato como nueva molécula de señalización extracelular en la regulación del desarrollo de aterosclerosis

    Funding entity: Agencia Estatal de Investigación

    Duration: 2021-2025

    Principal Investigator: Cedó Giné, Lídia

  • Title: PI21/01479: Oxilipinas en la diabetes gestacional y su relación con el fenotipo materno y de la descendencia

    Funding entity: Megía Colet, Ana

    Duration: 2022-2024

    Principal Investigator: Megía Colet, Ana

    Team member: Klid Klid, Sergiy; Guarque Rus, Albert; Martínez Guasch, Laia; Maymo Masip, Elsa; Ballesteros Pérez, Mónica

  • Title: Innovation Project 210008: Diabetic Retinopathy risk assessment using image-based deep learning and clinical variables

    Funding entity: EIT Health

    Duration: 2022-2024

    Principal Investigator: Joan Vendrell Ortega, MD, Phd

  • Title: Metabolitos como nuevos sensores energeticos. Efectos beneficiosos sobre la salud metabólica en la obesidad, comparando restricción calórica diaria vs ayuno intermitente. Estudio Randomiado-Cruzado. PI20/00338

    Funding entity: Instituto de Salud Carlos III.

    Duration: 2021-2024

    Principal Investigator: Joan Vendrell Ortega, MD, Phd.

    Team member: Solano Fraile, María Esther; Martí Mezcua, María Del Carmen

  • Title: Succinate/SUCNR1 axis: a novel target for anti-obesity therapies (METASUCC).

    Funding entity: Obra Social Fundació La Caixa (Proyectos Investigación en Salud 2020).

    Duration: 2020 – 2023

    Principal Investigator: Sonia Fernández-Veledo, Phd

  • Title: RTI2018-093919. Succinate as a new extracellular signalling metabolite govern in glucose homeostasis: SUCNR1, a molecular drug target in obesity and related diseases (SUC-HOM)

    Funding entity: Ministerio de Economía y Competitividad.

    Duration: 2019 – 2021

    Principal Investigator: Sonia Fernández-Veledo, Phd.

  • Title: Foo4Health

    Funding entity: EIT Health and EIT Food

    Duration: 2019

    Principal Investigator: Joan Vendrell Ortega, MD, Phd.

  • Title: Papel de la vía del succinato en la inflamación de los injertos renales procedentes de donantes cadáver.

    Funding entity: MXVI Convocatoria para la adjudicación de Ayudas a Proyectos de Investigación en salud 2019 de la Fundación Mutua Madrileña.

    Duration: 2019 – 2021

    Principal Investigator: Encarnación Díaz, MD, Phd (Fundació Puigvert).

  • Title: Eje Succinato/SUCNR1 en la diabetes gestacional: implicación de la inflamación en su function placentaria y su repercussion en el feto (PI18/00516).

    Funding entity: Instituto de Salud Carlos III.

    Duration: 2019 – 2021

    Principal Investigator: Ana Megia, MD, PhD

  • Title: An integrative analysis of DNA methylation and RNA-Seq data in human adipose-stem cells of Crohn’s disease patients with different clinical activity.

    Funding entity: European Crohn´s and Colitis Foundation.

    Duration: 2019 – 2020

    Principal Investigator: Carolina Serena, PhD.

  • Title: El tejido adiposo perilesional (creeping fat) como elemento inmunomodulador de la disbiosis  intestinal en la enfermedad de Crohn (PI18/00037)

    Funding entity: Instituto de Salud Carlos III.

    Duration: 2019 – 2021

    Principal Investigator: Carolina Serena, PhD.

  • Title: Microbiota tumor metabolic regulation as prognostic factors in HNSCC. (LABAE18025AVIL)

    Funding entity: Asociación Española Contra el Cáncer (AEC).

    Duration: 2019-2022

    Principal Investigator: Francesc Xavier Avilés, MD, PhD.

    Collaboration. co-IP: Sonia Fernández-Veledo, PhD.

  • Title: Variabilidad funcional de las células madre mesenquimales del tejido adiposo (ASCs) tras la pérdida de peso. Relación con metafactores vinculados a la microbiota intestinal (PI17/01503)

    Funding entity: Instituto de Salud Carlos III

    Duration: 2018 – 2020

    Principal Investigator: Joan Vendrell Ortega, MD, PhD

    Coordinated project. Coordinator: Joan Vendrell Ortega, MD, PhD.

  • Title: Analyses of the global kinase activities in adipose tissue to find molecular differences resulting from insulin resistance across different clinical phenotypes from lean to obese and type 2 diabetic patients. Discovery of new targets for therapy (86/C/2016).

    Funding entity: Fundació La Marató TV3.

    Duration: 2017 – 2019

    Principal Investigator: Joan Vendrell Ortega, MD, PhD.

    Coordinated project. Coordinator: Joan Vendrell Ortega, MD, PhD.

  • Title: Mechanisms responsible for the defective differentiation capacity of adipose-derived stem cells in obesity: Identification of new regulators amenable for the development of innovative therapies (225/C/2016).

    Funding entity: Fundació La Marató TV3.

    Duration: 2017 – 2019

    Principal Investigator: Sonia Fernández Veledo, PhD.

    Coordinated project. Coordinator: Antonio Zorzano, PhD.

  • Title: New probiotic strategies for obesity-related disorders and development of the companion diagnostic kit. IU68-018623. 2019 INNOV 00008

    Funding entity: AGAUR AJUT INNOVADORS

    Duration: 2020– 2022

    Principal Investigator: Sonia Fernández-Veledo

  • Title: Nuevas Estrategias probióticas para la obesidad y desarrollo de su kit diagnostico. IU68-017106

    Funding entity: AGAUR AJUT PRODUCTE

    Duration: 2020 – 2021

    Principal Investigator: Sonia Fernández-Veledo

  • Title: Valorització d’una nova estratègia probiòtica pel tractament de la obesitat i el desenvolupament d’un kit auto usuari pel maneig diagnòstic/terapèutic. R2B2019/11

    Funding entity: URV. Research bussiness

    Duration: 2020

    Principal Investigator: Sonia Fernández-Veledo

  • Title: Validació i estudi de valorització d’un nou mètode de selecció de cèl·lules mare mesenquimals (MSCs). R2B2018/07

    Funding entity: URV Research bussiness

    Duration: 2019

    Principal Investigator: Sonia Fernández-Veledo

  • Title: A new probiotic strategy to improve metabolic and inflammatory profile in obese patients. SUCCIPRO.

    Funding entity: Caixaimpulse. Fundación la Caixa.

    Duration: 2019 – 2021

    Principal Investigator: Isabel Huber

  • Title: DTS19/00040. New probiotic strategies for obesity-related disturbances and its companion diagnostic.

    Funding entity: Instituto de salud Carlos III.

    Duration: 2019 – 2021

    Principal Investigator: Sonia Fernández Veledo

  • Title: Mechanisms responsible for the defective differentiation capacity of adipose-derived stem cells in obesity: identification of new regulation amenable for the development of innovative therapies.

    Funding entity: Fundació La Marató TV3.

    Duration: 2017 – 2020

    Principal Investigator: Sonia Fernández Veledo

  • Title: 2017 SGR 01440 Suport a Grups de Recerca (SGR) IISPV finançament – Grup de Recerca Emergent

    Funding entity: Agència de Gestió d’Ajuts Universitaris i de Recerca

    Duration: 2017 – 2021

    Principal Investigator: Sonia Fernández Veledo

  • Title: Convocatoria dels ajuts d’industria del coneixements per a l’any 2019 (llavor i peoducte), susceptibles de ser confinçats, pel fons europeu de desenvolupament regional (FEDER) (REF.BDNS 458466) IU68-017106.

    Funding entity: Agència de Gestió d’Ajuts Universitaris i de Recerca

    Duration: 2020 – 2022

    Principal Investigator: Sonia Fernández Veledo

  • Title: Ajuts per a projectes de valorització i transferència de coneixement desenvolupats per innovadors en estades en entitats del sistema de recerca i innovació de Catalunya (Innovadors 2019) Codi operació IU68-018623.

    Funding entity: Agència de Gestió d’Ajuts Universitaris i de Recerca

    Duration: 2020 – 2022

    Principal Investigator: Sonia Fernández Veledo

  • Title:  Succinate / SUCNR1 Axis: A novel target for anti-obesity therapies (HR20-00051).

    Funding entity: Fundació Bancària Caixa d’Estalvis i Pensions de Barcelona

    Duration: 2020 – 2023

    Principal Investigator: Sonia Fernández Veledo

  • Title: 2017 SGR 01224 Suport a grups de recerca (SGR) URV – IISPV Finançament – Grup de recerca consolidat

    Funding entity: Agència de Gestió d’Ajuts Universitaris i de Recerca

    Duration: 2017 – 2021

    Principal Investigator: Joan Vendrell Ortega

  • Title: Variabilidad Funcional de las Células madre Mesenquimales del tejido adiposo (ASCs) tras la pérdida de peso. Relación con metafactores vinculados a la microbiota intestinal (PI17/01503).

    Funding entity: Instituto de Salud Carlos III

    Duration: 2018 – 2021

    Principal Investigator: Joan Vendrell Ortega

  • Title: New probiotic strategies for obesity-related disorders (CI19-00055).

    Funding entity: Fundació Bancària Caixa d’Estalvis i Pensions de Barcelona

    Duration: 2019 – 2021

    Principal Investigator: Isabel Huber Ruano

  • Title: CB07/08/0012 CIBER

    Funding entity: Instituto Carlos III

    Duration: 2008 – 2025

    Principal Investigator: Joan Vendrell Ortega

  • [1] EP24383078 – Enzymes capable of reducing succinate levels and uses thereof. Inventors: J. Vendrell; S. Fernández Veledo; J. Seco; I. Huber; C. Grau; H. Van Beek; D. Schonauer; E. Oliveira. Priority country: Europe (2024). Patent owners: SUCCIPRO, URV, IISPV, CIBERDEM.

  • [2] Licensed Patent: WO2019141780 – Targeted Interventions for Reducing Circulating Succinate Levels, Kits, and Methods for Evaluating Intervention Effectiveness. Inventors: S. Fernández Veledo, J. Vendrell, C. Serena, V. Ceperuelo Mallafré, E. Calvo. Priority Country: Europe (2019). Patent Owners: URV, IISPV, CIBERDEM.

  • [3] WO2021001303 – Succinate as a Biomarker for Selecting Bariatric Surgery Procedures and Predicting T2D Remission Post-Surgery. Inventors: S. Fernández Veledo, J. Vendrell, V. Ceperuelo Mallafré, N. Vilarrassa, G. Llauradó. Priority Country: Europe (2019). Patent Owners: URV, IISPV, CIBERDEM. [4] EP17382615.7 – Methods for Enhancing Cell Therapy Efficacy Using Mesenchymal Stem Cell Populations. Inventors: S. Fernández Veledo, J. Vendrell, C. Serena, A. Zorzano. Priority Country: Europe (2017). Patent Owners: URV, IISPV, CIBERDEM.

  • Title: Targeted interventions directed at reducing the levels of circulating succinate in a subject, and kits and method for determining effectiveness of said interventions.

    Reference number: PCT/EP2019/051157.

    Inventors: Sonia Fernández-Veledo; Joan Vendrell; Carolina Serena; Victoria Ceperuelo-Mallafré; Enrique Calvo.

    Registration date: 2019

  • Title: Succinate as a biomarker for selecting a bariatric surgical procedure and for predicting type 2 diabetes mission after bariatric surgery.

    Reference number: EP1938254. 

    Inventors:Sonia Fernández-Veledo; Joan Vendrell; Victoria Ceperuelo-Mallafré; Nuria Vilarrasa; Gemma Llauradó.

    Registration date: 2019

  • Title: Targeted interventions directed at reducing the levels of circulating succinate ina a subject, and kits and method for determining effectiveness of said interventions.

    Reference number: EP18382020.8.

    Inventors:Sonia Fernández-Veledo; Joan Vendrell; Carolina serena; Victoria Ceperuelo-Mallafré

    Registration date: 2018

  • Title: Methods for improving the cell therapy efficacy with mesenchymal stem cell populations España.

    Reference number: EP17382615.7.

    Inventors: Sonia Fernández-Veledo; Joan Vendrell; Carolina Serena; Antonio Zorzano.

    Registration Date: 2017

  • Title: Use of BPI protein for the treatment of disorders of the metabolism and cardiovascular disorders.

    Inventors: Mellitus SL (Joan Vendrell Ortega).

    Registratiion Date: 2007

  • Title: Method for detecting a predisposition to develop gestational diabetes mellitus and treatment for this disease.

    Inventors: Mellitus SL (Joan Vendrell Ortega).

    Registration Date: 2005

  • Title: Use of soluble CD14 for treatment of diseases.

    Inventors: Mellitus SL (Joan Vendrell Ortega).

    Registration Date: 2004

    SUCNR1 coordinates metabolic flux, mitochondrial function, and nutrient-dependent adaptation in hepatocytes.

    Marsal-Beltran A, Salmerón-Pelado L, Ribas-Latre A, Repollés-de-Dalmau M, Rodríguez-Peña MM, Núñez-Roa C, Badia J, Madeira A, Novoa E, Beltrà M, Plata-Gómez AB, Capellades J, Escolà-Gil JC, Zorzano A, Yanes Ó, Efeyan A, Nogueiras R, Gracia-Sancho J, Vendrell J, Ceperuelo-Mallafré V, Fernández-Veledo S. 12/06/2026. Science advances. 12. PMID: 42284407. doi: 10.1126/sciadv.aec8873

    Sex-specific dynamics of MASLD reveal early hepatic and extrahepatic metabolic deterioration in females despite long-term protection.

    Repollés-de-Dalmau M, Marsal-Beltran A, Núñez-Roa C, Vendrell J, Ceperuelo-Mallafré V, Fernández-Veledo S. 22/03/2026. Biology of Sex Differences. 17. PMID: 41866527. doi: 10.1186/s13293-026-00876-y

    Insulin resistance modulates gut microbiota and incretin response remodeling after bariatric surgery in severe obesity.

    Puig R, Rodríguez-Peña MM, Hernández-Montoliu L, Astiarraga B, Martínez E, Balibrea JM, Llauradó G, Tarascó J, Caballero A, Joaquín C, Puig-Domingo M, Vilarrasa N, Fernández-Veledo S, Vendrell J, Pellitero S. 01/03/2026. International Journal Of Obesity. 50. PMID: 41520055. doi: 10.1038/s41366-025-01971-7

    Liver fibrosis and type 2 diabetes modulate postprandial incretin and glucagon responses in fatty liver disease.

    Astiarraga B, Rodriguez-Castellano A, Ceperuelo-Mallafré V, Marsal-Beltran A, Osuna-Prieto FJ, Vilanova N, Gracia-Sancho J, Quer JC, Megía A, Balteiro AP, Vendrell J, Fernández-Veledo S. 06/02/2026. Journal Of Physiology And Biochemistry. 82. PMID: 41649634. doi: 10.1007/s13105-026-01141-x

    Evaluating human serum for trace levels of lipophilic organic chemicals: A novel GC-(Q)Orbitrap methodology

    Jiménez-Nieto, A, Izquierdo-Sandoval, D, Sancho, JV, Granell, M, González-Ruiz, A, Ballesteros, M, Vilanova, N, Megia, A, Gago-Ferrero, P, Domingo, JL, Marquès, M, Portolés, T, Gil-Solsona, R. 01/02/2026. Talanta. 298. PMID: 41014650. doi: 10.1016/j.talanta.2025.128897

    Insulin resistance and abdominal adiposity discriminate early vascular aging (higher vascular risk) in adults with type 1 diabetes without cardiovascular events

    Llaurado, G, Cano, A, Giménez-Palop, O, Albert, L, Pareja, R, Fernández-Veledo, S, Vendrell, J, González-Clemente, JM. 01/01/2026. Diabetes Research And Clinical Practice. 231. PMID: 41271109. doi: 10.1016/j.diabres.2025.113010

    Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn's disease

    Boronat-Toscano, A, Queipo-Ortuño, MI, Monfort-Ferré, D, Suau, R, Vaño-Segarra, I, Valldosera, G, Cepero, C, Astiarraga, B, Clua-Ferré, L, Plaza-Andrade, I, Aranega-Martín, L, Cabrinety, L, de Barbarà, CA, Castellano-Castillo, D, Moliné, A, Caro, A, Domènech, E, Sánchez-Herrero, JF, Benaiges-Fernandez, R, Fernández-Veledo, S, Vendrell, J, Ginés, I, Sumoy, L, Manyé, J, Menacho, M, Serena, C. 07/12/2025. World Journal Of Gastroenterology. 31. PMID: 41378335. doi: 10.3748/wjg.v31.i45.112618

    Guanine and pregnenolone sulfate are associated with incident type 2 diabetes in two independent populations

    Barranco-Altirriba, M, Granado-Casas, M, Yanes, O, Capellades, J, Junza, A, Franch-Nadal, J, Vendrell, J, Llaurado, G, Valdés, S, García-Escobar, E, Bermúdez-Lopez, M, Valdivielso, JM, Lopez-Lifante, VM, Herrero-Alonso, C, Falguera, M, Vilanova, MB, Arteaga, I, Torán-Monserrat, P, Perera-Lluna, A, Castelblanco, E, Mauricio, D. 03/12/2025. Frontiers in endocrinology. 16. PMID: 41416067. doi: 10.3389/fendo.2025.1706886

    From the gut to disease: Microbiota-derived short chain fatty acids and their precursors lactate and succinate in atherosclerosis and cancer

    Cedo, L, Madeira, A, Caro, P. 01/12/2025. SEMINARS IN CANCER BIOLOGY. 117. PMID: 41197753. doi: 10.1016/j.semcancer.2025.10.007

    Hepatocyte-derived extracellular vesicles promote endothelial dedifferentiation in chronic liver disease through the miR-153-3p-pyroptosis axis

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    A Real-World Study Comparing Advanced Hybrid Closed-Loop Systems During Pregnancy in Women with Type 1 Diabetes

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    Reduced Systemic Levels of Bile Acids in Individuals with Coronary Artery Disease: Insights from a Systematic Review

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    Moderate-intensity exercise training uniquely modulates circulating lipid species beyond classical lipid levels in humans.

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    Dietary switch and intermittent fasting ameliorate the disrupted postprandial short-chain fatty acid response in diet-induced obese mice

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    The serine protease KLK7 promotes immune cell infiltration in visceral adipose tissue in obesity

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    Circulating short-chain fatty acids and Mediterranean food patterns. A potential role for the prediction of type 2 diabetes risk: The Di@bet.es Study

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    The role of microbial succinate in the pathophysiology of inflammatory bowel disease: mechanisms and therapeutic potential

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    Impact of 24-week concurrent training on bone parameters and plasma levels of osteoglycin and sclerostin in young, sedentary adults: secondary analyses from the ACTIBATE randomized controlled trial

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    Impaired angiogenesis in gestational diabetes is linked to succinate/SUCNR1 axis dysregulation in late gestation

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    Omics for searching plasma biomarkers associated with unfavorable COVID-19 progression in hypertensive patients

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    Outcomes for Patients with Obesity Undergoing Adrenalectomy for Pheochromocytoma: An International Multicenter Analysis

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    Elevated Circulating Succinate in Crohn's Disease Correlates with Gut Microbiota Alterations and Inflammatory Activity

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    Survivin/BIRC5 as a novel molecular effector at the crossroads of glucose metabolism and radioresistance in head and neck squamous cell carcinoma

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    Type 2 diabetes and succinate: unmasking an age-old molecule

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    Higher plasma levels of endocannabinoids and analogues are correlated with a worse cardiometabolic profile in middle-aged adults

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    Influence of smoking on cardiometabolic profile and surgical outcomes in patients with primary aldosteronism: a cohort study

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    Alx3 deficiency disrupts energy homeostasis, alters body composition, and impairs hypothalamic regulation of food intake

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    Proceedings of the 5th Meeting of Translational Hepatology, organized by the Spanish Association for the Study of the Liver (AEEH)

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    The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk

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    Genetic Testing for Primary Aldosteronism in SPAIN: Results From the SPAIN-ALDO Registry and Review of the Literature

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    Folate and cobalamin status, indicators, modulators, interactions, and reference ranges from early pregnancy until birth: the Reus-Tarragona birth cohort study

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    GLP-1 Receptor Agonist Treatment Improves Fasting and Postprandial Lipidomic Profiles Independently of Diabetes and Weight Loss

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    Inflammatory Status in Deceased Kidney Donors Led by Impaired Mitochondrial Metabolism through the HIF1a Hypoxia Pathway

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    Impact of primary aldosteronism on kidney function: results from the SPAIN-ALDO registry

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    Type 1 diabetes: Is silent myocardial ischaemia associated with blinded continuous glucose monitoring metrics? Results from a pilot study

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    Diet-driven succinate production by intestinal microbiota stimulates GLP-1 secretion by colonic enteroendocrine cells via SUCNR1

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    Increased postprandial succinate levels are associated with hepatic gluconeogenesis regulation via SUCNR1

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    Neurological-related proteomic profiling in plasma of children with metabolic healthy and unhealthy overweight/obesity

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    Pregnancy in an obese and gestational diabetes context: epigenetic regulation of adipose tissue

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    Predicting hepatic decompensation in patients with metabolic dysfunction-associated fatty liver disease-related cirrhosis: The ABID-LSM model

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    Time-restricted eating, the clock ticking behind the scenes

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    DECIPHERING THE EXTRACELLULAR EFFECTS OF SUCCINATE IN ATHEROSCLEROTIC DISEASE PROGRESSION: A TRANSLATIONAL APPROACH

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    Genome-wide DNA Methylome and Transcriptome Profiling Reveals Key Genes Involved in the Dysregulation of Adipose Stem Cells in Crohn's Disease

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    SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes

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    Emerging role of the succinate/SUCNR1 axis in microglial metabolism: from physiology to pathology

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    Prematurity and congenital malformations differ according to the type of pregestational diabetes

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    Effects of Hypertriglyceridemia With or Without NEFA Elevation on ß-cell Function and Insulin Clearance and Sensitivity

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    Cold exposure modulates potential brown adipokines in humans, but only FGF21 is associated with brown adipose tissue volume

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    Differences in the clinical and hormonal presentation of patients with familial and sporadic primary aldosteronism

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    Inflammatory Environment-Induced Transcriptomic Alterations in Crohn's Disease Adipose Stem Cells

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    The NDDG criteria versus the IADPSG or the ADA criteria for diagnosing early-onset gestational diabetes mellitus or abnormal glucose tolerance

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    Pregnancy homocysteine and cobalamin status predict childhood metabolic health in the offspring

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    Hydroxytyrosol Induces Dyslipidemia in an ApoB100 Humanized Mouse Model

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    Protocol for the in vitro isolation and culture of mature adipocytes and white adipose tissue explants from humans and mice.

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    Circulating short-chain fatty acids and Mediterranean food patterns: a potential role for the prediction of type 2 diabetes risk

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    The angiogenic properties of human amniotic membrane stem cells are enhanced in gestational diabetes and associate with fetal adiposity (vol 12, 608, 2021)

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    Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria.

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    Deciphering the sex bias in housekeeping gene expression in adipose tissue: a comprehensive meta-analysis of transcriptomic studies

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    SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression

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    Matrix Metalloproteinase-9 Expression Is Associated with the Absence of Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Patients

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    Micro-elimination of chronic hepatitis C virus in patients with psychiatric disorders: a multidisciplinary strategy in the outpatient mental health center

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    Edoxaban Versus Low-Molecular-Weight Heparin in Hospitalized COVID-19 Patients With Atrial Fibrillation

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    Effectiveness of a direct care action strategy at the drug addiction center (test and treat in point of care) for the detection and treatment of hepatitis C in drug users on opioid agonist substitution therapy

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    Prognostic Implications of the Residual Tumor Microenvironment after Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Patients without Pathological Complete Response

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    Glycemic disorders in patients with pheochromocytomas and sympathetic paragangliomas

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    Opposing Actions of TLR2 and TLR4 in Adipocyte Differentiation and Mature-Onset Obesity

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    High frequency of acute decompensation and cancer in patients with compensated cirrhosis due to nonalcoholic fatty liver disease: A retrospective cohort study

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    The Gut Microbiota Metabolite Succinate Promotes Adipose Tissue Browning in Crohn's Disease

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    Anti-TNF Therapies Suppress Adipose Tissue Inflammation in Crohn's Disease

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    Measurement of Serum N-Glycans in the Assessment of Early Vascular Aging (Arterial Stiffness) in Adults With Type 1 Diabetes

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    DNA Methylation in Gestational Diabetes and its Predictive Value for Postpartum Glucose Disturbances

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    Circulating pyruvate is a potent prognostic marker for critical COVID-19 outcomes

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    Soluble factors influencing the neural stem cell niche in brain physiology, inflammation, and aging

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    Circulating succinate response is associated with insulin sensitivity and glucose tolerance

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    Circulating short chain fatty acids as potential new biomarkers for the prediction of type 2 diabetes risk

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    Orally administered Odoribacter laneus improves glucose control and inflammatory profile in obese mice by depleting circulating succinate

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    Fasting Glucose for the Diagnosis of Gestational Diabetes Mellitus (GDM) during the COVID-19 Pandemic

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    Glycogen accumulation in adipocyte precursors from elderly and obese subjects triggers inflammation via SIRT1/6 signaling

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    Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue

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