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Col·labora

Nutrigenòmica

MALALTIES METABÒLIQUES I NUTRICIÓ
NUTRICIÓ DIABETIS OBESITAT COLESTEROL
http://www.nutrigenomica.recerca.urv.cat
OBJECTIUS

El grup de recerca en Nutrigenòmica de la IRB CatSud-URV té com a objectiu general la generació de coneixement orientat al disseny d’aliments funcionals capaços de prevenir, endarrerir o pal·liar malalties metabòliques com l’obesitat, la diabetis, la hipertensió i la síndrome metabòlica. A més a més, aquests estudis també permeten la revalorització de subproductes de la indústria alimentària mitjançant l’obtenció d’ingredients funcionals.

RESPONSABLES

  • Dra. Begoña Muguerza

  • Línies de recerca
  • Projectes
  • Transferència
  • Membres del grup
  • Patents
  • Publicacions
  • Contacte
  • Avaluació dels efectes beneficiosos dels compostos fenòlics sobre patologies relacionades amb la síndrome metabòlica amb especial atenció als polifenols
  • Desenvolupament d’un aliment integral per a la pèrdua de pes corporal i la prevenció de patologies associades a l’obesitat
  • Influència dels ritmes biològics en l’efecte d’ingredients bioactius
  • Estudi de la interacció entre compostos bioactius i microRNAs
  • Obtenció i purificació de pèptids bioactius
  • Cerca de compostos bioactius amb capacitat de modular la microbiota
  • Valorització de subproductes de la industria agroalimentària

  • ESTUDIO DE LA INTERACCIÓN DE LOS RITMOS CIRCADIANOS Y ESTACIONALES CON LA EFECTIVIDAD DE LOS INGREDIENTES FUNCIONALES
    AGL2016-77105-R
    Begoña Muguerza, Anna Arola
    Duració 2016 – 2019
    Ministerio de Economía, Industria y Competitividad (MINECO)

  • DESARROLLO Y VALIDACIÓN DE UNA BEBIDA FUNCIONAL PARA EL CONTROL DE LA PRESIÓN ARTERIAL- HYPERGRAPES (RETOS)
    RTC-2017-6044-2
    Begoña Muguerza, Francisca I. Bravo
    Duració 2018 – 2021
    Ministerio de Ciencia, Innovación y Universidades

  • IDENTIFICACIÓN DE METABOLITOS DERIVADOS DE BACTERIAS QUE ACTIVAN A RECEPTORES ACOPLADOS A PROTEÍNA G (GPCR)
    Francisca I. Bravo
    Duració 2019 -2019
    Ministerio de Ciencia, Innovación y Universidades

  • PECT DE REUS I EL CAMP DE TARRAGONA PER A UNA ALIMENTACIÓ INNOVADORA, SEGURA, SALUDABLE I SOSTENIBLE PER AL BENESTAR DE LA POBLACIÓ I L’IMPULS DEL TERRITORI (NUTRISALT)
    Cinta Bladé, Begoña Muguerza
    Duració 2017 – 2019
    Generalitat de Catalunya

  • PROYECTO PLATAFORMA PARA LA OBTENCIÓN DE HIDROLIZADOS RICOS EN PÉPTIDOS BIOACTIVOS (PEP)
    2017R2B-04
    Francisca I. Bravo
    Duració 2018 – 2019
    Universitat Rovira i Virgili

  • MULTI‐INGREDIENT FUNCIONAL PER AL TRACTAMENT DE L’OBESITAT (REDOBES)
    2017R2B‐05
    Gerard Aragonès
    Duració 2018-2019
    Universitat Rovira i Virgili

  • Consumo de uvas con diferente contenido de (poli)fenoles en la adaptación al Fotoperiodo estacional (PHOTOGRAPE)
    PID2023-150028OB-I00
    Begoña Muguerza Marquínez, Anna Arola Arnal
    Duración 2024-2027
    Ministerio de Ciencia, Innovación y Universidades

  • Estudio de los efectos de hidrolizados proteicos sobre enfermedades asociadas al síndrome metabólico y de la involucración de la microbiota intestinal  (PROTMETBIOTA)
    PID2023-151563OB-I00
    Cristina Torres Fuentes, Francisca Isabel Bravo Vázquez
    Duración 2024-2027
    Ministerio de Ciencia, Innovación y Universidades

  • Efectos de compuestos fenólicos en alteraciones causadas por la interrupción del ritmo circadiano (CIRCAFENOL)
    PID2021-128813OB-I00
    Manuel Suárez-Recio
    Duración 2022-2025
    Ministerio de Ciencia, Innovación y Universidades

  • Escalado y valorización de hidrolizados con péptidos antihipertensivos obtenidos de subproductos alimentarios (ESVALPEP)
    PDC2021-121625-I00
    Begoña Muguerza Marquínez
    Duración 2021-2023
    Ministerio de Ciencia, Innovación y Universidad

  • Investigación, desarrollo y validación de un nutracéutico para la prevención de la hipertensión y el síndrome metabólico (NUTRAPREMET)
    CPP2021-008511
    Francisca Isabel Bravo Vázquez, Gerard Aragonès Bargalló
    Duración 2022-2025
    Ministerio de Ciencia, Innovación y Universidades

  • Interacción entre hidrolizados proteicos y microbiota intestinal. Potencial prebiótico y promoción de la producción de posbióticos con efecto antihipertensivo (PROTBIOTIC)
    PID2020-114608RA-I00
    Cristina Torres Fuentes, Francisca Isabel Bravo Vázquez
    Duración 2021-2024
    Ministerio de Ciencia, Innovación y Universidades

  • Multiingredientes estacionales con base fenólica para la prevención de patologías asociadas a la obesidad (SEASONAL MIX)
    PID2020-113739RB-I00
    Begoña Muguerza Marquínez, Anna Arola Arnal
    Duración 2021-2024
    Ministerio de Ciencia, Innovación y Universidades

  • COMPOSICIÓN HIPOLEPTINÉMICA Y SU USO
    F.I. Bravo, M. Suárez, A. Arola-Arnal, B. Muguerza, M.J. Salvadó, L. Arola, A. Crescenti, A. Pascual-Serrano, M. Ibars, A. Ardid-Ruiz, A. Gibert, A. Mas-Capdevila, M. Martín-González, C. Bladé, G. Aragonès.
    P201930732- PCT/ES2020/070483
    Espanya
    Data de prioritat 06/08/2019
    Universitat Rovira i Virgili (URV)

  • HIDROLIZADOS DE GARRAS DE PATAS DE POLLO, SUS PÉPTIDOS Y USOS DE LOS MISMOS
    F. I. Bravo, M. Pinent, A. Casanova-Martí, A. Ardèvol, J. Serrano, L. Arola, B. Muguerza
    ES2702617 B2
    Espanya
    Data de prioritat 04/09/2017
    Universitat Rovira i Virgili (URV)

  • ÁCIDO GÁLICO PARA EL TRATAMIENTO DE PATOLOGÍAS DE LA HIPERACTIVACIÓN DEL SISTEMA RENINA ANGIOTENSINA ALDOSTERONA (SRAA)
    Z. Pons, M. Margalef, F. I. Bravo, A. Arola-Arnal, M. Suárez, L. Arola, B. Muguerza
    P201531587 – ES2611667B1
    Espanya
    Data de prioritat 08/02/2018
    Universitat Rovira i Virgili (URV)

  • PROCEDIMIENTOS PARA LA OBTENCIÓN DE UN HIDROLIZADO DE GARRAS DE PATA DE POLLO CON ACTIVIDAD ANTIHIPERTENSIVA, HIDROLIZADO OBTENIDO Y PÉPTIDOS QUE CONTIENE
    F.I. Bravo, L. Arola, B. Muguerza
    P201531372 PCT/EP2016/072326 (WO2017/050775) ES2606954B1
    Espanya
    Data de prioritat 11/12/2017
    Universitat Rovira i Virgili (URV) – EURECAT

  • Generación de argumentos científicos sobre el consumo de productos de proximidad (PECT-NUTRISALT)
    GAH/815/2018
    Diputació de Tarragona, Ajuntament de Reus, IRTA, Eurecat, Universitat Rovira I Virgili
    Begoña Muguerza Marquínez
    Periodo 2017 – 2020

  • Obtención y screening de hidrolizados proteicos con potencial antiinflamatorio y/o analgésico
    T19189S
    Uriach Consumer Healthcare, Universitat Rovira i Virgili
    Begoña Muguerza Marquínez
    Fecha de prioridad 28/02/2021

  • Ensayo de validación del proceso de AM3 mediante de inhibición de la producción de factor de necrosis tumoral (TNF) inducida por endotoxina bacteriana (LPS) in vitro sobre células THP-1
    T20168S
    Industrial Farmacéutica Cantabria, S.A., Universitat Rovira i Virgili
    Begoña Muguerza Marquínez, Francisco Javier Ávila Román
    Fecha de prioridad 21/09/2020

  • Descubrimiento y obtención de compuestos bioactivos con actividad despigmentante cutánea a través de procesos autofágicos y nuevas dianas
    (MELANINHIBS)
    T21307S
    Bella Aurora Labs, S.A., Universitat Rovira i Virgili
    Miquel Mulero Abellán, Begoña Muguerza Marquínez, Francisca Isabel Bravo Vázquez
    Fecha de prioridad 30/06/2023

  • Solubilización de nutrientes no disponibles del suelo mediante bioestimulantes microbianos
    Azufrera y Fertilizantes Pallarès, S.A.U., Universitat Rovira i Virgili
    Anna Arola Arnal
    Fecha finalización 19/10/2024

  • Nuevas presentaciones y aplicaciones de la diaminooxidasa (DAO) en el mercado
    DR Healthcare España, S.L., Universitat Rovira I Virgili
    Begoña Muguerza Marquínez
    Fecha finalización 31/01/2025

  • Ingrediente funcional para el control del síndrome metabólico T22212S
    Pharmalink S.L., Universitat Rovira i Virgili
    Begoña Muguerza Marquínez, Gerard Aragonès Bargalló, Francisca Isabel Bravo Vázquez
    Fecha de prioridad 31/05/2025

  • Sistema de nanopartículas que comprenden un metal, recubierto de polietilenglicol (PEG), el cual está funcionalizado con un ácido orgánico de tipo polifenol, procedimiento de fabricación y uso de dicho sistema
    Inventores: Francisco Javier de la Mata, Paula Ortega, Siham Bouaouz, Rebeca Lozano,
    Cornelia Emeritina Peña, Enrique Calvo, Francisca Isabel Bravo, Miquel Mulero, Begoña
    Muguerza
    Número de solicitud/patente: P202430695
    País de prioridad: España
    Fecha de prioridad: 02/09/2024
    Entidad titular: Universitat Rovira i Virgili (URV) y Universidad de Alcalá de Henares

  • Hydrolysed collagen, process for its preparation and uses thereof

    Inventores: F.I. Bravo, N. Ibarz-Blanch, Clara Urueña, N. Hospital, M. Mulero, X. Escoté,
    J.M. Alcaide, J.M. del Bas, R.M. Raventós, B. Muguerza
    Número de solicitud/patente: P220144/IT/MBE
    País de prioridad: Italia
    Fecha de prioridad: 31/10/2022
    Entidad titular: Uriach Consumer Healthcare. S.L.

  • Protein hydrolysates of azuki beans and cosmetic uses thereof
    Inventores: R. Subirós; A. Soley; C. García; N. Alminyana; N. Ibarz-Blanch; B.Muguerza, F.I. Bravo
    Número de solicitud/patente: EP22382248.7 (PCT/IB2023/052524)
    País de prioridad: España
    Fecha de prioridad: 16/03/2022
    Entidad titular: Lubrizol Advanced Materials, Inc.

  • Wine lees, derivatives thereof and their uses
    Inventores: F.I. Bravo, R. López-Fernández, J.M. Alcaide-Hidalgo, M. Margalef, A. Mas-Capdevila, J.M. del Bas, M.E. Hérnandez, B. Muguerza
    Número de solicitud/patente: EP20382358.8 (PCT/EP2021/053051)
    País de prioridad: España
    Fecha de prioridad: 30/04/2020
    Entidad titular: Grandes Vinos y Viñedos

  • Composición hipoleptinémica y su uso
    Inventores: F.I. Bravo, M. Suárez, A. Arola-Arnal, B. Muguerza, M. J. Salvadó, A. Crescenti, A. Pascual-Serrano, M. Ibars, A. Ardiz-Ruiz, A. Gibert-Ramos, A. Mas-Capdevila, M. Martín-González, C. Bladé, G. Aragonès
    Número de solicitud/patente: ES2804649B2 (PCT/ES2020/070483)
    País de prioridad: España
    Fecha de prioridad: 06/08/2019
    Entidad titular: Universitat Rovira i Virgili (URV) y Eurecat

  • Hidrolizados de garras de patas de pollo, sus péptidos y usos de los mismos. Chicken feet hydrolysates, their peptides and uses

    Inventores: F.I. Bravo, M. Pinent, A. Casanova-Martí, A. Ardèvol, J. Serrano, L. Arola, B. Muguerza
    Número de solicitud/patente: ES2702617B2
    País de prioridad: España
    Fecha de prioridad: 04/09/2017
    Entidad titular: Universitat Rovira i Virgili (URV)

  • Ácido gálico para el tratamiento de patologías de la hiperactivación del sistema renina angiotensina aldosterona (SRAA). Gallic acid for the treatment of pathologies of the hyperactivation of the Renin-Angiotensin-Aldosterone System (RAAS)
    Inventores: Z. Pons, M. Margalef, F.I. Bravo, A. Arola-Arnal, M. Suarez, L. Arola, B. Muguerza
    Número de solicitud/patente: ES2611667B1
    País de prioridad: España
    Fecha de prioridad: 05/11/2015
    Entidad titular: Universitat Rovira i Virgili (URV)

  • Procedimiento para la obtención de un hidrolizado de garras de pata de pollo con actividad antihipertensiva, hidrolizado obtenido y péptidos que contiene
    Inventores: F.I. Bravo, L. Arola, B. Muguerza
    Número de solicitud/patente: ES2606954B1 (PCT/EP2016/072326)
    País de prioridad: España
    Fecha de prioridad: 25/09/2015
    Entidad titular: Universitat Rovira i Virgili (URV)

    Año

    Sex- and photoperiod-dependent differences in the bioavailability of (poly)phenols from mixtures of seasonal fruit extracts in obese rats.

    Gómez-Roncal S, Ávila-Gálvez MÁ, Alemany-Fornés M, Soliz-Rueda JR, Muguerza B, Espín JC, Arola-Arnal A. 01/07/2026. Food Research International. 235. PMID: 42083179. doi: 10.1016/j.foodres.2026.119110

    Adiponectin modulates the diurnal hepatic transcriptome and energy metabolism in male mice.

    Hirose M, Calvo E, Pilorz V, Kaehler M, Cascorbi I, Nagel I, de Assis LVM, Oster H. 24/04/2026. Endocrine Connections. 15. PMID: 41983416. doi: 10.1530/EC-26-0016

    Significant Activity of Pytren-2Q, a 2-Quinoline Polyamine Compound, against High-Concern Human Pathogenic Fungi.

    Inclán M, Clares MP, Álvarez-Duarte E, Fernández-Silva F, Salas V, Guarro J, Chicote JU, Verdejo B, Delgado-Pinar E, García-España E, García-España A, Calvo E. 17/02/2026. ACS Omega. 11. PMID: 41726695. doi: 10.1021/acsomega.5c09700

    Caffeic acid-functionalized silver nanoparticles for skin therapy: Antioxidant, antibacterial, and anti-melanogenic properties

    Bouaouz, S, Lozano, R, Bravo, FI, Muguerza, B, Mulero, M, Calvo, E, Ortega, P, de la Mata, J. 01/02/2026. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. 116. doi: 10.1016/j.jddst.2025.107937

    Chrononutritional Effects of Cherry Consumption on Hepatic Lipid Profile.

    Ruiz de Azua MJ, Manocchio F, Cruz-Carrión Á, Arola-Arnal A, Gerstner C, Bernal C, Suárez M. 21/01/2026. Nutrients. 18. PMID: 41599958. doi: 10.3390/nu18020345

    S2CIE: semantic, syntactic, and context-based information extraction for AOP development

    Kumar, S, Sharma, S, Deepika, D, Biosca-Brull, J, Moreno, A, Kumar, V. 01/01/2026. Environment International. 207. PMID: 41386052. doi: 10.1016/j.envint.2025.109986

    Impact of Intended Isocaloric Early versus Late Time-Restricted Eating on Plasma Lipidome in Women with Overweight or Obesity: Secondary Analysis of the ChronoFast Trial.

    Szekely K, Gerl MJ, Peters B, Schwarz J, Schuppelius B, Damm M, Soliz-Rueda JR, Sehgal R, Lazaratos M, Klose C, Simons K, Pfeiffer AFH, Schürmann A, Kramer A, Michalsen A, Pivovarova-Ramich O. 01/01/2026. Advanced Science. 13. PMID: 41186047. doi: 10.1002/advs.202507149

    Neuroprotective effects of polyphenol-rich extracts obtained from agricultural by-products in an induced cognitive decline model of zebrafish larvae and in human neurons.

    Castillo-Moral Á, Tchoumtchoua J, Leonard K, Del Bas JM, Ortega N, Escoté X, Teichenné J. 01/12/2025. Biomedicine & Pharmacotherapy. 193. PMID: 41232357. doi: 10.1016/j.biopha.2025.118776

    Interaction Between Photoperiod and Sex on Hepatic Lipid Homeostasis in Rats Fed an Obesogenic Diet

    Gomez-Roncal, S, García-Reyes, FC, Soliz-Rueda, JR, Calvo, E, Suárez, M, Muguerza, B, Arola-Arnal, A. 27/11/2025. Faseb Journal. 39. PMID: 41307196. doi: 10.1096/fj.202503210R

    Grape Seed Flavanols Restore Peripheral Clock of White Adipose Tissue in Obese Rats Under Circadian Alterations

    García-Martínez-Salvador, M, Colom-Pellicer, M, Podolakova, E, Mulero, M, Aragonès, G, Soliz-Rueda, JR, Muguerza, B. 14/11/2025. Nutrients. 17. PMID: 41305614. doi: 10.3390/nu17223564

    Microbial Biotransformation of Agro-Industrial Fibre-Rich By-Products into Functional Beverages.

    Sentís-Moré P, Robles-Rodríguez I, Leonard K, Tchoumtchoua J, Escoté-Miró X, Del Bas-Prior JM, Ortega-Olivé N. 05/11/2025. Antioxidants. 14. PMID: 41300489. doi: 10.3390/antiox14111332

    Sex impact on daily activity and physiological, metabolic and hormonal responses to different photoperiod regimens in diet-induced obese fischer 344 rats

    Gómez-Roncal, S, Gironès-Garreta, A, Suárez, M, Muguerza, B, Aragonès, G, Mulero, M, Arola-Arnal, A. 01/11/2025. Journal Of Physiology And Biochemistry. 81. PMID: 40493338. doi: 10.1007/s13105-025-01075-w

    A Combination of Lacticaseibacillus paracasei CECT 30660 and Bifidobacterium longum subsp. infantis CECT 7210 Cell-Free Supernatants Reduces LPS-Induced Preterm Birth and Systemic Inflammation in Pregnant Mice

    Quesada-Vázquez, S, García, MCD, Cifuentes-Orjuela, G, Antolín, A, Alcaide-Hidalgo, JM, Jiménez, J, Puiggròs, F, Caimari, A, Sabench, F, Del Bas, JM, Escoté, X, Moreno-Muñoz, JA. 31/10/2025. Nutrients. 17. PMID: 41228502. doi: 10.3390/nu17213429

    Circannual Rhythms Affect the Bioavailability of Phenolic Compounds from Grape Seed Proanthocyanidins Extract Differently in Healthy and Obese Fischer 344 Rats

    Escobar-Martinez, I, Arreaza-Gil, V, Arola-Arnal, A, Muguerza, B, Mulero, M, Suarez, M, Torres-Fuentes, C. 08/10/2025. Journal Of Agricultural And Food Chemistry. 73. PMID: 41002217. doi: 10.1021/acs.jafc.5c03952

    Diamine oxidase deficiency implications for health, current management, and future directions in the treatment of histamine intolerance: A review.

    Alemany-Fornés M, Bori J, Muguerza B, Suárez M. 01/10/2025. International Journal Of Biological Macromolecules. 327. PMID: 40865824. doi: 10.1016/j.ijbiomac.2025.147130

    Impact of the natural female reproductive aging on the rat serum lipidome.

    Baudin J, Antolín A, Fernández-Arroyo S, Del Pino A, Mulero F, Puiggròs F, Arola L, Caimari A. 18/09/2025. Clinical Science. 139. PMID: 40891175. doi: 10.1042/CS20255841

    Interplay between (poly)phenols, gut microbiota, and biological rhythms: outlook for a new paradigm in brain health

    Torres-Fuentes, C, Schellekens, H, Cryan, JF, Espin, JC, Muguerza, B. 10/09/2025. Critical Reviews In Food Science And Nutrition. 66. PMID: 40944699. doi: 10.1080/10408398.2025.2559367

    Impact of a high-fat diet on spatial learning and memory: The role of sex, APOE genotype, and postnatal chlorpyrifos exposure

    Guardia-Escote, L, Biosca-Brull, J, Blanco, J, Cabré, M, Basaure, P, Pérez-Fernández, C, Sánchez-Santed, F, Domingo, JL, Colomina, MT. 01/09/2025. Neurotoxicology. 110. PMID: 40653054. doi: 10.1016/j.neuro.2025.07.004

    Photoperiod-Dependent Effects of Phenolic-Enriched Fruit Extracts on Postprandial Triacylglyceride Levels and Acute Inflammatory Responses in F344 Rats

    Manocchio, F, Morales, D, Navarro-Masip, E, Aragones, G, Torres-Fuentes, C, Bravo, FI, Muguerza, B. 01/08/2025. Molecular Nutrition & Food Research. 69. PMID: 40411868. doi: 10.1002/mnfr.70126

    Resveratrol Prevents Weight Gain, Counteracts Visceral Adipose Tissue Dysfunction, and Improves Hypothalamic Leptin Sensitivity in Diet-Induced Obese Rats.

    Ibars-Serra M, Pascual-Serrano A, Ardid-Ruiz A, Doladé N, Aguilar-González S, Cirasino J, Muguerza B, Suárez M, Keijer J, Arola-Arnal A, Aragonès G. 01/08/2025. Molecular Nutrition & Food Research. 69. PMID: 40289401. doi: 10.1002/mnfr.70075

    Molecular Imprints of Clinical Comorbidities in Hypothalamic Extracellular Vesicles at the Onset of Obesity.

    Fernández-Rhodes M, Suárez M, Molet I, Suárez-García S, Arola L, Sze SK, Gallart-Palau X, Serra A. 10/06/2025. ACS Omega. 10. PMID: 40521556. doi: 10.1021/acsomega.5c02274

    Grape seed procyanidins modulate PER2 circadian rhythm and lipid metabolism of white adipose tissue explants in a time-dependent manner

    Colom-Pellicer, M, de Assis, LVM, Rodríguez, RM, Suaárez, M, Mulero, M, Arola-Arnal, A, Oster, H, Aragonès, G, Calvo, E. 19/05/2025. International Journal Of Food Sciences And Nutrition. 76. PMID: 40300822. doi: 10.1080/09637486.2025.2494151

    Foodomics approaches: New insights in phenolic compounds analysis

    Gómez-Rocal, S, Cruz-Carrión, A, Morales, D, García-Ruiz, A, Suárez, M, Arola-Arnal, A. 01/05/2025. Food Research International. 208. PMID: 40263832. doi: 10.1016/j.foodres.2025.116168

    Clock system disruption in male Fischer 344 rats fed cafeteria diet and administered sweet treats at different times: The zeitgeber role of grape seed flavanols

    Soliz-Rueda, JR, López-Fernández-Sobrino, R, Schellekens, H, Bravo, FI, Suárez, M, Mulero, M, Muguerza, B. 20/01/2025. Biofactors. 51. PMID: 39832727. doi: 10.1002/biof.70000

    Gut microbiota and eating behaviour in circadian syndrome.

    Soliz-Rueda JR, Cuesta-Marti C, O’Mahony SM, Clarke G, Schellekens H, Muguerza B. 01/01/2025. TRENDS IN ENDOCRINOLOGY AND METABOLISM. 36. PMID: 39095231. doi: 10.1016/j.tem.2024.07.008

    Guidance and Position of RINN22 regarding Precision Nutrition and Nutriomics.

    Ramos-Lopez O, Assmann TS, Astudillo Muñoz EY, Baquerizo-Sedano L, Barrón-Cabrera E, Bernal CA, Bressan J, Cuevas-Sierra A, Dávalos A, De la Cruz-Mosso U, De la Garza AL, De Luis DA, Díaz de la Garza RI, Dos Santos K, Fernández-Condori RC, Fernández-Quintela A, Garcia Diaz DF, Gonzalez-Becerra K, Lopes Rosado E, López de Las Hazas MC, Marín Alejandre BA, Angel Martin A, Martinez-Lopez E, Martínez-Urbistondo D, Milagro FI, Hermsdorff HHM, Muguerza B, Nicoletti CF, Obregón Rivas AM, Parra-Rojas I, Portillo MP, Santos JL, Steemburgo T, Tejero ME, Terán AC, Treviño V, Vizmanos B, Martinez JA. 01/01/2025. Lifestyle Genomics. 18. PMID: 39617000. doi: 10.1159/000542789

    Grape-Seed Proanthocyanidin Extract (GSPE) Modulates Diurnal Rhythms of Hepatic Metabolic Genes and Metabolites, and Reduces Lipid Deposition in Cafeteria-Fed Rats in a Time-of-Day-Dependent Manner

    Rodríguez, RM, de Assis, LVM, Calvo, E, Colom-Pellicer, M, Quesada-Vázquez, S, Cruz-Carrión, A, Escoté, X, Oster, H, Aragonès, G, Mulero, M. 01/12/2024. Molecular Nutrition & Food Research. 68. PMID: 39523911. doi: 10.1002/mnfr.202400554

    Sweet cherries modulate thyroid hormones and hepatic glucose metabolism in F344 rats in a photoperiod-dependent manner

    Manocchio, F, de Azua, MJR, Navarro-Masip, E, Morales, D, Aragonès, G, Torres-Fuentes, C, Muguerza, B, Bravo, FI. 01/10/2024. Journal Of Functional Foods. 121. doi: 10.1016/j.jff.2024.106415

    A cocktail of histidine, carnosine, cysteine and serine reduces adiposity and improves metabolic health and adipose tissue immunometabolic function in ovariectomized rats

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    Sex Differences in the Absorption, Disposition, Metabolism, and Excretion of Grape Seed Proanthocyanidins in Prepubescent Rats

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    Photoperiod-Dependent Effects on Blood Biochemical Markers of Phenolic-Enriched Fruit Extracts

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    Usefulness of Opuntia spp. on the Management of Obesity and Its Metabolic Co-Morbidities

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    Valorization of Peach Fruit and Wine Lees through the Production of a Functional Peach and Grape Juice

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    Cherries with Different Geographical Origins Regulate Neuroprotection in a Photoperiod-Dependent Manner in F344 Rats

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    Exploring Metabolic and Gut Microbiome Responses to Paraquat Administration in Male Wistar Rats: Implications for Oxidative Stress

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    Novel kombucha beverages with antioxidant activity based on fruits as alternative substrates

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    Photoperiod-Dependent Effects of Grape-Seed Proanthocyanidins on Adipose Tissue Metabolic Markers in Healthy Rats

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    Vitis vinifera L. Bioactive Components Modulate Adipose Tissue Metabolic Markers of Healthy Rats in a Photoperiod-Dependent Manner.

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    Rhythm and ROS: Hepatic Chronotherapeutic Features of Grape Seed Proanthocyanidin Extract Treatment in Cafeteria Diet-Fed Rats

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    Metabolism disturbance by light/dark cycle switching depends on the rat health status: the role of grape seed flavanols

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    Valorization of Chicken Slaughterhouse Byproducts to Obtain Antihypertensive Peptides

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    Grape Seed Proanthocyanidins Modulate the Hepatic Molecular Clock via MicroRNAs

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    Maternal Supplementation with a Cocoa Extract during Lactation Deeply Modulates Dams' Metabolism, Increases Adiponectin Circulating Levels and Improves the Inflammatory Profile in Obese Rat Offspring

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    Reduction of Obesity and Insulin Resistance through Dual Targeting of VAT and BAT by a Novel Combination of Metabolic Cofactors

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    Do You Have Problems When Reproducing Bioactivities of Food or Food Components? The Importance of Biological Rhythms

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    Microbiota Dysbiosis and Gut Barrier Dysfunction Associated with Non-Alcoholic Fatty Liver Disease Are Modulated by a Specific Metabolic Cofactors' Combination

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    Serum lysophospholipidome of dietary origin as a suitable susceptibility/risk biomarker of human hypercholesterolemia: Letter to the editor

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    Role of Chrononutrition in the Antihypertensive Effects of Natural Bioactive Compounds

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    Structured Long-Chain Omega-3 Fatty Acids for Improvement of Cognitive Function during Aging

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