Presentació dels Hospitals
Col·labora

Laboratori Interdisciplinari de Metabolòmica (MiL@b)

MALALTIES METABÒLIQUES I NUTRICIÓ
NUTRICIÓ DIABETIS OBESITAT COLESTEROL
http://metabolomicsplatform.com/
OBJECTIUS

La Plataforma Metabolòmica (PM), creada l’any 2007, és una infraestructura de recerca  conjunta entre el CIBERDEM i la Universitat Rovira i Virgili (URV) per a la prestació de serveis tecnològics en l’àmbit de la metabolòmica. La PM forma també part de l’IRB CatSud. L’objectiu principal és treballar com un laboratori integrat pels grups CIBERDEM, dels centres CIBER i de l’IRB CatSud, ajudant-los a dissenyar els experiments de metabolòmica, realitzar-ne els experiments, processar les dades i avaluar-ne els resultats.

RESPONSABLES

  • Maria Vinaixa Crevillent

  • Presentació
  • Línies de recerca
  • Projectes
  • Membres del grup
  • Ajudes
  • Publicacions
  • Contacte

La PM te accés a equipament analític d’última generació en espectrometria de masses i ressonància magnètica nuclear, que  permeten l’anàlisi a gran escala de mostres biològiques. L’ús d’estadística avançada, quimiometria i algoritmes multivariants permet transformar un elevat conjunt de dades experimentals en  perfils metabòlics i en última instància en informació clínica. Les dades experimentals són processades per l’equip de la plataforma, facilitant la interpretació dels resultats i proporcionant conclusions clíniques sòlides, rellevants i útils pels diferents grups de recerca.

  • Processat de dades metabolòmiques i identificació de metabòlits per LC-MS i GC-MS. Integració de tecnologies òmiques. Etiquetatge d’isòtops estables i fluxòmica per MS i NMR.
  • Imatges d’espectrometria sense marcatge per aplicacions biològiques.
  • Processat i anàlisi avançat de dades metabolòmiques per a tècniques analítiques i aplicacions clíniques multidimensionals.
  • Metabolòmica per RMN.
  • Metabolòmica toxicològica i ambiental.

  • Títol: AYUDAS JUAN DE LA CIERVA – INCORPORACION 2015
    Referència: IJCI-2015-23158
    Entitat finançadora: Instituto de Salud Carlos III
    Durada: 01/09/2017 – 31/08/2019

  • Títol: TYPE OF ACTION: RELIABLE AND SPECIFIC URINARY BIOMARKERS FOR COLORECTAL CANCER (COLOVOC)
    Referència: H2020-MSCA-IF-2017; PROPOSAL NUMBER: 798038
    Entitat finançadora: MARIE CURIE HORIZON 2020
    Durada: 01/09/2017 – 30/06/2022

  • Títol: ESTANCIAS DE MOVILIDAD EN EL EXTRANJERO ‘JOSE CASTILLEJO’ PARA JOVENES DOCTORES
    Referència: —
    Entitat finançadora: Ministerio de Ciencia, Innovacion y Universidades
    Durada: 08/07/2019 – 30/09/2019

  • Títol:
    Referència: EIN2019-102898
    Entitat finançadora: Ministerio de Ciencia, Innovacion y Universidades
    Durada: 01/06/2019 – 31/05/2020

  • Títol: EPIGENETIC AND METABOLIC ALTERATIONS ASSOCIATED TO EARLY CHILDHOOD EXPOSURE TO AIR POLLUTION AND ITS ROLE IN LATER LIFE CHRONIC DISEASE (ECHOES)
    Referència:
    Entitat finançadora: RECERCA SOCIAL “LA CAIXA”
    Durada: 01/01/2020 – 31/12/2021

  • Títol: Development of a signal and data processing workflow for 2D
    hyphenated chromatography based on multi-way algorithms: Application to urine metabolomics data for colorectal cancer screening (TensorChrom)
    Referència:
    Entitat finançadora: Ministerio de Ciencia, Innovacion y Universidades
    Durada: 01/01/2019 – 31/12/2022

  • Títol: Desarrollo de nuevas tecnologías de histología molecular basadas en espectroscopia de imágenes y su aplicación al estudio del cáncer y la diabetes (hisMOL4CANdia)
    Referència:
    Entitat finançadora: Ministerio de Ciencia, Innovacion y Universidades
    Durada: 01/01/2019 – 31/12/2022

  • Títol: Ayudas Juan de la Cierva-incorporación
    Referència: IJCI-2017-33438
    Entitat finançadora: Ministerio de Economía y Competitividad
    Durada: 01/01/2019 – 31/12/2021

  • Title: CB07/08/0014 CIBER

    Funding entity: Instituto de Salud Carlos III

    Duration: 2008 – 2025

    Principal Investigator: Xavier Correig Blanchar

  • CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM). (CB07/08/0014)

  • RED ESPAÑOLA DE METABOLÓMICA

    Año

    SUCNR1 coordinates metabolic flux, mitochondrial function, and nutrient-dependent adaptation in hepatocytes.

    Marsal-Beltran A, Salmerón-Pelado L, Ribas-Latre A, Repollés-de-Dalmau M, Rodríguez-Peña MM, Núñez-Roa C, Badia J, Madeira A, Novoa E, Beltrà M, Plata-Gómez AB, Capellades J, Escolà-Gil JC, Zorzano A, Yanes Ó, Efeyan A, Nogueiras R, Gracia-Sancho J, Vendrell J, Ceperuelo-Mallafré V, Fernández-Veledo S. 12/06/2026. Science advances. 12. PMID: 42284407. doi: 10.1126/sciadv.aec8873

    Role of activity and fibrosis in the MASLD atherogenic momentum through advanced lipidomics.

    Blanco-Echevarría A, Costa Segovia R, Guijarro Herraiz C, García Izquierdo B, Guadalix S, Pérez Carreras M, Rodríguez Gil Y, de Castro Martínez M, Amigó N, D’Avola D, Lumbreras Bermejo C, Martínez-Urbistondo D. 13/05/2026. Plos One. 21. PMID: 42127133. doi: 10.1371/journal.pone.0343134

    Limitations of current animal models in atherosclerosis: an integrative multiomics perspective.

    Kardassis D, Amigó N, Mitic T. 22/04/2026. European Heart Journal. 47. PMID: 41556948. doi: 10.1093/eurheartj/ehaf997

    Chronic kidney disease induces a distinct lipidomic signature and accelerates atherosclerosis progression in a novel minipig model.

    Bermúdez-López M, Nogales P, Martí-Antonio M, Castro-Boqué E, de Lamo VM, Beà-Menchón L, Luis-Lima S, Porrini E, Sanchez-Salguero X, Jové M, Obis E, Mota-Martorell N, Pérez-Gómez A, Garcia-Carrasco A, Bozic M, Guajardo J, Pérez-Sánchez CJ, Cambray S, Amigó N, Pamplona R, Bentzon JF, Valdivielso JM. 02/04/2026. Laboratory Animal Research. 42. PMID: 41928358. doi: 10.1186/s42826-026-00274-w

    Multiomics for Risk Stratification in Atherosclerotic Cardiovascular Disease.

    Nordestgaard LT, Magni P, Sopic M, Chemaly M, Matic L, Dalila N, Trindade F, Wolford BN, Rodriguez-Hernandez Z, Amigó N, Catapano AL, Masana L, Devaux Y. 01/04/2026. Circulation-Genomic and Precision Medicine. 19. PMID: 41878824. doi: 10.1161/CIRCGEN.125.005451

    Effect of combined aerobic and resistance training on kidney health in adults with type 2 diabetes: A randomized controlled trial.

    Burton O, Díaz-López A, Villalobos F, Pedret R, Arija V. 24/03/2026. DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS. 20. PMID: 41886945. doi: 10.1016/j.dsx.2026.103404

    Assessment of physical status and analysis of lipidomic and metabolomic alterations in patients with Post-COVID-19 condition.

    Pavón R, Parra S, Rubio FJ, Feliu M, Ríos M, Iftimie S, Rovira C, Amigó N, Cabau L, Martínez-Micaelo N, Castro A. 03/03/2026. Plos One. 21. PMID: 41774679. doi: 10.1371/journal.pone.0341192

    Antifungal and anti-virulence activities of cinnamon, thyme, and clove essential oils against Candida species.

    Ahaik I, Nunez-Rodriguez JC, Abelló-Cros S, Yanes O, Bouhdid S, Gabaldón T. 02/03/2026. Frontiers in Pharmacology. 17. PMID: 41847137. doi: 10.3389/fphar.2026.1756267

    Disease-specific crosstalk of Alistipes with lipoprotein profiles in overweight individuals at high cardiometabolic risk.

    Cuevas-Sierra A, Higuera-Gómez A, de Cuevillas B, Amigó N, Martínez-Urbistondo M, Castejón R, Vargas JA, Martínez JA. 13/02/2026. Scientific Reports. 16. PMID: 41688554. doi: 10.1038/s41598-026-36024-0

    FASN targeting by G28UCM impairs mitochondrial fatty acid synthesis and reveals a FASN-SDHB synthetic interaction.

    Wilfinger-Lutz N, Kuehrer KM, Bueno MJ, Schwaiger-Haber M, Ann WW, Krejci K, Mekis R, Gobbo Oliveira Erünlü N, Miller A, Junza A, Reipert S, Bergmann M, Yanes O, Haschemi A, Koellensperger G, Quintela-Fandino M, Nowikovsky K. 01/02/2026. Pharmacological Research. 224. PMID: 41520938. doi: 10.1016/j.phrs.2026.108087

    Multilayer metabolomic integration reveals bioenergetic disruption in Long COVID.

    García-Hidalgo MC, Mota-Martorell N, González J, Benítez ID, Company-Marín I, Jové M, Barbé F, Amigó N, Pamplona R, de Gonzalo-Calvo D, Torres G. 20/01/2026. Journal Of Translational Medicine. 24. PMID: 41559790. doi: 10.1186/s12967-026-07684-3

    Small intestine is not colon: a new in vitro model of the human ileum microbiome integrating the mucosal microenvironment and feeding status.

    Bron A, Beltramo C, Durif C, Arora T, Deschamps C, Couturier I, Domingo-Almenara X, Otero YF, Denis S, Van de Wiele T, Blanquet-Diot S. 31/12/2025. Gut microbes. 17. PMID: 41277251. doi: 10.1080/19490976.2025.2579353

    Comparing Campylobacter jejuni to three other enteric pathogens in OligoMM12 mice reveals pathogen-specific host and microbiota responses

    Herzog, MKM, Peters, A, Shayya, N, Cazzaniga, M, Bra, KK, Arora, T, Barthel, M, Gül, E, Maurer, L, Kiefer, P, Christen, P, Endhardt, K, Vorholt, JA, Frankel, G, Heimesaat, MM, Bereswill, S, Gahan, CGM, Claesson, MJ, Domingo-Almenara, X, Hardt, WD. 31/12/2025. Gut microbes. 17. PMID: 39835346. doi: 10.1080/19490976.2024.2447832

    A Perspective on Unintentional Fragments and Their Impact on the Dark Metabolome, Untargeted Profiling, Molecular Networking, Public Data, and Repository Scale Analysis

    El Abiead, Y, Mohanty, I, Xing, SP, Rutz, A, Charron-Lamoureux, V, Damiani, T, Lu, WY, Patti, GJ, Zamboni, N, Yanes, O, Dorrestein, PC. 22/12/2025. JACS Au. 5. PMID: 41450660. doi: 10.1021/jacsau.5c01063

    A Robust Multivariate Approach Unveils a 1H-NMR-Based Spectral Metabolomics Signature Predictive of Cardiovascular Disease in People with Type 2 Diabetes: A Prospective Di@bet.es Cohort Study

    Rehues, P, Guardiola, M, Amigo, N, Rojo-Martinez, G, Mallol-Parera, R, Ribalta, J. 05/12/2025. Journal Of Proteome Research. 24. PMID: 41258650. doi: 10.1021/acs.jproteome.5c00662

    Guanine and pregnenolone sulfate are associated with incident type 2 diabetes in two independent populations

    Barranco-Altirriba, M, Granado-Casas, M, Yanes, O, Capellades, J, Junza, A, Franch-Nadal, J, Vendrell, J, Llaurado, G, Valdés, S, García-Escobar, E, Bermúdez-Lopez, M, Valdivielso, JM, Lopez-Lifante, VM, Herrero-Alonso, C, Falguera, M, Vilanova, MB, Arteaga, I, Torán-Monserrat, P, Perera-Lluna, A, Castelblanco, E, Mauricio, D. 03/12/2025. Frontiers in endocrinology. 16. PMID: 41416067. doi: 10.3389/fendo.2025.1706886

    Widespread lipoprotein alterations in a REDUCE-IT like population: The icosapent ethyl (IPE)-NMR avatar study

    Masana, L, Torné, P, Garcia-Moll, X, Dalli, E, Amigo, N. 01/11/2025. Nutrition Metabolism And Cardiovascular Diseases. 35. PMID: 40651885. doi: 10.1016/j.numecd.2025.104199

    A Potential Ratio for Detecting Subclinical Atherosclerosis: Insight into Advanced NMR Lipid Profiles in Severe Obesity

    Carmona-Maurici, J, Eskubi-Turró, I, Viñas, A, Ricart-Jané, D, López-Tejero, MD, Amigó, N, Bermúdez, M, Baena-Fustegueras, JA, Peinado-Onsurbe, J, Pardina, E. 29/10/2025. Journal of Cardiovascular Translational Research. 18. PMID: 41160327. doi: 10.1007/s12265-025-10696-x

    The multiomics blueprint of the individual with the most extreme lifespan

    Santos-Pujol, E, Noguera-Castells, A, Casado-Pelaez, M, García-Prieto, CA, Vasallo, C, Campillo-Marcos, I, Quero-Dotor, C, Crespo-García, E, Bueno-Costa, A, Setién, F, Ferrer, G, Davalos, V, Mereu, E, Pluvinet, R, Arribas, C, de la Torre, C, Villavicencio, F, Sumoy, L, Granada, I, Coles, NS, Acha, P, Solé, F, Mallo, M, Mata, C, Peregrina, S, Gabaldón, T, Llirós, M, Pujolassos, M, Carreras-Torres, R, Lluansí, A, García-Gil, LJ, Aldeguer, X, Samino, S, Torné, P, Ribalta, J, Guardiola, M, Amigó, N, Yanes, O, Martínez, P, Sánchez-Vásquez, R, Blasco, MA, Oviedo, J, Lemos, B, Rius-Bonet, J, Torrubiano, M, Massip-Salcedo, M, Khidir, KA, Cao, TH, Quinn, PA, Jones, DJL, Macip, S, Brigos-Barril, E, Moldes, M, Barteri, F, Muntané, G, Laayouni, H, Navarro, A, Esteller, M. 21/10/2025. Cell Reports Medicine. 6. PMID: 40997805. doi: 10.1016/j.xcrm.2025.102368

    Microbiota Shape Metabolic and Immune Determinants of CAR-T Therapy and Correlate with Outcomes in Myeloma

    Uribe-Herranz, M, Oliver-Caldés, A, Martínez-Micaelo, N, Español-Rego, M, Val-Casals, M, Martínez-Soler, R, Rubio-Garcia, E, Brunello, V, Mihelic, EZ, Klein-González, N, Benítez-Ribas, D, Amigó, N, Vergara, A, Ortiz-Maldonado, V, Rodríguez-Lobato, LG, Delgado, J, de Landazuri, IO, González-Calle, V, Cabañas, V, Martin-Antonio, B, Pérez-Amill, L, Reguera-Ortega, JL, Rodríguez-Otero, P, Paiva, B, Martínez-López, J, Mateos, MV, Pascal, M, Urbano-Ispizua, A, González-Navarro, EA, de Larrea, CF, Juan, ME. 03/09/2025. Blood cancer discovery. 6. PMID: 40643584. doi: 10.1158/2643-3230.BCD-24-0203

    Multiomics in atherosclerotic cardiovascular disease

    Nordestgaard, LT, Wolford, BN, de Gonzalo-Calvo, D, Sopic, M, Devaux, Y, Matic, L, Wettinger, SB, Schmid, JA, Amigó, N, Masana, L, Catapano, AL, Kardassis, D, Magni, P. 01/09/2025. Atherosclerosis. 408. PMID: 40663987. doi: 10.1016/j.atherosclerosis.2025.120414

    Current status and challenges of multi-omics research using animal models of atherosclerosis

    Mitic, T, Georgescu, A, Alexandru-Moise, N, Davies, MJ, Vindis, C, Novella, S, Gerdts, E, Kararigas, G, Wettinger, SB, Formosa, MM, Kwak, BR, Molica, F, Amigo, N, Caporali, A, de la Cuesta, F, Hall, IF, Chroni, A, Martelli, F, Schmid, JA, Magni, P, Kardassis, D. 01/09/2025. Journal Of Molecular And Cellular Cardiology Plus. 13. PMID: 40726539. doi: 10.1016/j.jmccpl.2025.100476

    Triglycerides as Determinants of Global Lipoprotein Derangement: Implications for Cardiovascular Prevention

    Amigó, N, Torne, P, Nordestgaard, LT, Di Giacomo-Barbagallo, F, Merino, C, Magni, P, González-Lleó, A, Andreychuk, N, Catapano, AL, Masana, L, Ibarretxe, D. 26/08/2025. International Journal Of Molecular Sciences. 26. PMID: 40943205. doi: 10.3390/ijms26178284

    Metabolomic and functional characterization of human cell models to investigate the pathogenetic mechanisms underlying obesity and metabolic dysfunction-associated steatotic liver disease

    Comi, L, Giglione, C, Klinaku, FT, Da Dalt, L, Ruiz, CM, Amigó, N, Magni, P. 01/08/2025. Atherosclerosis. 407

    apoC-III proteoforms are associated with better lipid, inflammatory, and glucose profiles

    Rehues, P, Girona, J, Guardiola, M, Ozcariz, E, Amigó, N, Rosales, R, Esteban, Y, Banús, H, Alsina, GG, González-Lleó, A, Rojo-Martínez, G, Ribalta, J. 01/08/2025. Atherosclerosis. 407

    SingleFrag: a deep learning tool for MS/MS fragment and spectral prediction and metabolite annotation

    Pérez-Ribera, M, Faizan-Khan, M, Giné, R, Badia, JM, Junza, A, Yanes, O, Sales-Pardo, M, Guimerà, R. 01/07/2025. BRIEFINGS IN BIOINFORMATICS. 26. PMID: 40641047. doi: 10.1093/bib/bbaf333

    Circulating short-chain fatty acids and Mediterranean food patterns. A potential role for the prediction of type 2 diabetes risk: The Di@bet.es Study

    Llauradó, G, Cedo, L, Climent, E, Badia, J, Rojo-Martínez, G, Roux, JFL, Yanes, O, Vinaixa, M, Granado-Casas, M, Mauricio, D, Fernández-Veledo, S, Vendrell, J. 06/06/2025. Bmc Medicine. 23. PMID: 40481510. doi: 10.1186/s12916-025-04186-9

    Initiating Empagliflozin and Sacubitril/Valsartan Early After Acute Myocardial Infarction: Mechanistic Study.

    Martínez-Falguera D, Aranyó J, Ferrer-Curriu G, Teis A, Revuelta-Lopez E, Diaz-Güemes I, Monguió-Tortajada M, Fadeuilhe E, Rodríguez-Leor O, Poblador F, Montejo B, Roura S, Villuendas R, Sarrias A, Bazan V, Jorge E, Delgado V, Jimenez-Trinidad FR, Rigol M, Martinez-Micaelo N, Amigó N, Bayes-Genis A, Bisbal F, Gálvez-Montón C. 03/06/2025. Journal of the American Heart Association. 14. PMID: 40417813. doi: 10.1161/JAHA.124.040214

    Urinary Hippuric Acid as a Sex-Dependent Biomarker for Fruit and Nut Intake Raised from the EAT-Lancet Index and Nuclear Magnetic Resonance Analysis

    Fernández-Cruz, E, de la O, V, Fernández-Diaz, CM, Matía-Martín, P, Rubio-Herrera, MA, Amigó, N, Calle-Pascual, AL, Martínez, JA. 23/05/2025. Metabolites. 15. PMID: 40559371. doi: 10.3390/metabo15060348

    Improving MALDI Mass Spectrometry Imaging Performance: Low-Temperature Thermal Evaporation for Controlled Matrix Deposition and Improved Image Quality.

    Mahamdi T, Serna CG, Giné R, Rofes J, Mohammed SA, Ràfols P, Correig X, García-Altares M, Hopf C, Iakab SA, Yanes O. 07/05/2025. Journal Of The American Society For Mass Spectrometry. 36. PMID: 40250832. doi: 10.1021/jasms.5c00015

    Lipidomic analysis reveals metabolism alteration associated with subclinical carotid atherosclerosis in type 2 diabetes

    Barranco-Altirriba, M, Rossell, J, Alonso, N, Weber, RJM, Ortega, E, Lloyd, GR, Hernandez, M, Yanes, O, Capellades, J, Winder, C, Junza, A, Falguera, M, Franch-Nadal, J, Dunn, WB, Perera-Lluna, A, Castelblanco, E, Mauricio, D. 02/04/2025. Cardiovascular Diabetology. 24. PMID: 40176064. doi: 10.1186/s12933-025-02701-z

    Advancing atherosclerosis research: The Power of lipid imaging with MALDI-MSI

    Bookmeyer, CHM, Correig, FX, Masana, L, Magni, P, Yanes, O, Vinaixa, M. 01/04/2025. Atherosclerosis. 403. PMID: 40059002. doi: 10.1016/j.atherosclerosis.2025.119130

    GcDUO: an open-source software for GC x GC-MS data analysis

    Llambrich, M, van der Kloet, FM, Sementé, L, Rodrigues, A, Samanipour, S, Stefanuto, PH, Westerhuis, JA, Cumeras, R, Brezmes, J. 04/03/2025. BRIEFINGS IN BIOINFORMATICS. 26. PMID: 40037642. doi: 10.1093/bib/bbaf080

    GDF15 Circulating Levels Are Associated with Metabolic-Associated Liver Injury and Atherosclerotic Cardiovascular Disease

    Girona, J, Guardiola, M, Barroso, E, García-Altares, M, Ibarretxe, D, Plana, N, Ribalta, J, Amigó, N, Correig, X, Vázquez-Carrera, M, Masana, L, Rodríguez-Calvo, R. 01/03/2025. International Journal Of Molecular Sciences. 26. PMID: 40076667. doi: 10.3390/ijms26052039

    Fecal metabolomics to understand intestinal dysfunction in male dairy beef calves at arrival to the rearing farm

    Bassols, A, Amigó, N, Pérez-Rodado, M, Saco, Y, Peña, R, Pato, R, Pisoni, L, Devant, M, Marti, S. 26/02/2025. Scientific Reports. 15. PMID: 40011507. doi: 10.1038/s41598-025-90407-3

    Advanced serum lipoprotein and glycoprotein profiling for cardiovascular event prediction in type 2 diabetes mellitus: the LIPOCAT study

    Amigó, N, Castelblanco, E, Julve, J, Martínez-Micaelo, N, Alonso, N, Hernández, M, Ribalta, J, Guardiola, M, Torán-Monserrat, P, Lopez-Lifante, V, Herrero-Alonso, C, Arteaga, I, Ortega, E, Franch-Nadal, J, Mauricio, D. 21/02/2025. Cardiovascular Diabetology. 24. PMID: 39985069. doi: 10.1186/s12933-025-02636-5

    Author Correction: Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging.

    Sola-García A, Cáliz-Molina MÁ, Espadas I, Petr M, Panadero-Morón C, González-Morán D, Martín-Vázquez ME, Narbona-Pérez ÁJ, López-Noriega L, Martínez-Corrales G, López-Fernández-Sobrino R, Castillo-Peña A, Carmona-Marin LM, Martínez-Force E, Yanes O, Vinaixa M, López-López D, Reyes JC, Dopazo J, Martín F, Gauthier BR, Scheibye-Knudsen M, Capilla-González V, Martín-Montalvo A. 12/02/2025. Communications Biology. 8. PMID: 39939695. doi: 10.1038/s42003-025-07659-y

    Ketone Bodies Are Potential Prognostic Biomarkers in Relapsed/Refractory Diffuse Large B-Cell Lymphoma: Results from the R2-GDP-GOTEL Trial

    Fernández-Castillejo, S, Badia, J, de la Cruz-merino, L, Garcia-Sáncho, AM, Carnicero-González, F, Palazón-Carrión, N, Ríos-Herranz, E, de la Cruz-vicente, F, Rueda-Domínguez, A, Martínez-Banaclocha, N, Gómez-Codina, J, Labrador, J, Martínez-Madueño, F, Amigó, N, Salar-Silvestre, A, Rodríguez-Abreu, D, Gálvez-Carvajal, L, Sánchez-Beato, M, Provencio-Pulla, M, Guirado-Risueño, M, Nogales, E, Sánchez-Margalet, V, Jiménez-Cortegana, C, Rodríguez-García, G, Cumeras, R, Gumà, J, Spanish Lymphoma Oncology Grp GOTEL. 01/02/2025. Cancers. 17. PMID: 39941898. doi: 10.3390/cancers17030532

    Long-term mitochondrial and metabolic impairment in lymphocytes of subjects who recovered after severe COVID-19

    Gómez-Delgado, I, López-Pastor, AR, González-Jiménez, A, Ramos-Acosta, C, Hernández-Garate, Y, Martínez-Micaelo, N, Amigó, N, Espino-Paisán, L, Anguita, E, Urcelay, E. 10/01/2025. Cell Biology And Toxicology. 41. PMID: 39792183. doi: 10.1007/s10565-024-09976-0

    H4K20me3-Mediated Repression of Inflammatory Genes Is a Characteristic and Targetable Vulnerability of Persister Cancer Cells

    Ramponi, V, Richart, L, Kovatcheva, M, Attolini, CSO, Capellades, J, Lord, AE, Yanes, O, Ficz, G, Serrano, M. 02/01/2025. Cancer Research. 85. PMID: 39476057. doi: 10.1158/0008-5472.CAN-24-0529

    Artificial intelligence: the human response to approach the complexity of big data in biology

    Melandri, G, R-Radohery, G, Beaumont, C, de Cripan, SM, Muller, C, Piras, L, Pereira, MA, Salvador, AF, Domingo-Almenara, X, Bolger, M, Colombié, S, Prigent, S, Arechederra, BG, Canela, NC, Pétriacq, P. 01/01/2025. Gigascience. 14. PMID: 40504538. doi: 10.1093/gigascience/giaf057

    SPME arrow-based extraction for enhanced targeted and untargeted urinary volatilomics

    Llambrich, M, Ramírez, N, Cumeras, R, Brezmes, J. 15/11/2024. Analytica Chimica Acta. 1329. PMID: 39396318. doi: 10.1016/j.aca.2024.343261

    The GDF15 3' UTR Polymorphism rs1054564 Is Associated with Diabetes and Subclinical Atherosclerosis

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    The untargeted urine volatilome for biomedical applications: methodology and volatilome database

    Llambrich, M, Brezmes, J, Cumeras, R. 01/12/2022. Biological Procedures Online. 24. PMID: 36456991. doi: 10.1186/s12575-022-00184-w

    BRAF activation by metabolic stress promotes glycolysis sensitizing NRASQ61-mutated melanomas to targeted therapy

    McGrail, K, Granado-Martínez, P, Esteve-Puig, R, García-Ortega, S, Ding, YX, Sánchez-Redondo, S, Ferrer, B, Hernandez-Losa, J, Canals, F, Manzano, A, Navarro-Sabaté, A, Bartrons, R, Yanes, O, Pérez-Alea, M, Muñoz-Couselo, E, Garcia-Patos, V, Recio, JA. 19/11/2022. Nature Communications. 13. PMID: 36402789. doi: 10.1038/s41467-022-34907-0

    Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese

    Canyelles, M, Pérez, A, Junza, A, Miñambres, I, Yanes, O, Sardà, H, Rotllan, N, Julve, J, Sánchez-Quesada, JL, Tondo, M, Escolà-Gil, JC, Blanco-Vaca, F. 01/11/2022. Diagnostics. 12. PMID: 36428843. doi: 10.3390/diagnostics12112783

    Urine NMR Metabolomics for Precision Oncology in Colorectal Cancer

    Brezmes, J, Llambrich, M, Cumeras, R, Gumà, J. 01/10/2022. International Journal Of Molecular Sciences. 23. PMID: 36232473. doi: 10.3390/ijms231911171

    Measurement of Serum N-Glycans in the Assessment of Early Vascular Aging (Arterial Stiffness) in Adults With Type 1 Diabetes

    Llauradó, G, Amigó, N, Fuertes-Martín, R, Romero, A, Cano, A, Albert, L, Giménez-Palop, O, Berlanga, E, Fernández-Veledo, S, Correig, X, Vendrell, J, González-Clemente, JM. 01/10/2022. Diabetes Care. 45. PMID: 35984043. doi: 10.2337/dc22-0331

    Urinary Metabolomics Study on the Protective Role of Cocoa in Zucker Diabetic Rats via 1H-NMR-Based Approach

    Fernández-Millán, E, Ramos, S, Alvarez-Cilleros, D, Samino, S, Amigó, N, Correig, X, Chagoyen, M, Alvarez, C, Martín, MA. 01/10/2022. Nutrients. 14. PMID: 36235779. doi: 10.3390/nu14194127

    Oncometabolite D-2HG alters T cell metabolism to impair CD8+T cell function

    Notarangelo, G, Spinelli, JB, Perez, EM, Baker, GJ, Kurmi, K, Elia, I, Stopka, SA, Baquer, G, Lin, JR, Golby, AJ, Joshi, S, Baron, HF, Drijvers, JM, Georgiev, P, Ringel, AE, Zaganjor, E, McBrayer, SK, Sorger, PK, Sharpe, AH, Wucherpfennig, KW, Santagata, S, Agar, NYR, Suva, ML, Haigis, MC. 30/09/2022. Science. 377. PMID: 36173860. doi: 10.1126/science.abj5104

    Circulating short chain fatty acids as potential new biomarkers for the prediction of type 2 diabetes risk

    Llaurado, G, Junza, A, Rubinat, E, Yanes, O, Correig, X, Mauricio, D, Vendrell, J, Fernández-Veledo, S. 01/09/2022. Diabetologia. 65

    Orally administered Odoribacter laneus improves glucose control and inflammatory profile in obese mice by depleting circulating succinate

    Huber-Ruano, I, Calvo, E, Mayneris-Perxachs, J, Rodríguez-Peña, MM, Ceperuelo-Mallafré, V, Cedó, L, Núñez-Roa, C, Miro-Blanch, J, Arnoriaga-Rodríguez, M, Balvay, A, Maudet, C, García-Roves, P, Yanes, O, Rabot, S, Grimaud, GM, De Prisco, A, Amoruso, A, Fernández-Real, JM, Vendrell, J, Fernández-Veledo, S. 25/08/2022. Microbiome. 10. PMID: 36002880. doi: 10.1186/s40168-022-01306-y

    HUMAN PLASMA GLYCOPROTEIN PROFILE MEASURED BY 1H-NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY IN PATIENTS WITH DIABETES AND/OR ATHEROGENIC DYSLIPIDEMIA, A NEW METHOD TO ASSESS INFLAMMATION

    Amigo, N, Fuertes, R, Malo, A, Plana, N, Ibarretxe, D, Girona, J, Correig, X, Masana, L. 01/08/2022. Atherosclerosis. 355

    Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue

    Gonzalez-Franquesa, A, Gama-Perez, P, Kulis, M, Szczepanowska, K, Dahdah, N, Moreno-Gomez, S, Latorre-Pellicer, A, Fernández-Ruiz, R, Aguilar-Mogas, A, Hoffman, A, Monelli, E, Samino, S, Miró-Blanch, J, Oemer, G, Duran, X, Sanchez-Rebordelo, E, Schneeberger, M, Obach, M, Montane, J, Castellano, G, Chapaprieta, V, Sun, WF, Navarro, L, Prieto, I, Castaño, C, Novials, A, Gomis, R, Monsalve, M, Claret, M, Graupera, M, Soria, G, Wolfrum, C, Vendrell, J, Fernández-Veledo, S, Enríquez, JA, Carracedo, A, Perales, JC, Nogueiras, R, Herrero, L, Trifunovic, A, Keller, MA, Yanes, O, Sales-Pardo, M, Guimerà, R, Blüher, M, Martín-Subero, JI, Garcia-Roves, PM. 01/08/2022. Redox biology. 54. PMID: 35777200. doi: 10.1016/j.redox.2022.102353

    What are we imaging? Software tools and experimental strategies for annotation and identification of small molecules in mass spectrometry imaging

    Baquer, G, Sementé, L, Mahamdi, T, Correig, X, Ràfols, P, García-Altares, M. 13/07/2022. Mass Spectrometry Reviews. 42. PMID: 35822576. doi: 10.1002/mas.21794

    Muscular carnosine is a marker for cardiorespiratory fitness and cardiometabolic risk factors in men with type 1 diabetes

    Brugnara, L, García, AI, Murillo, S, Ribalta, J, Fernandez, G, Marquez, S, Rodriguez, MA, Vinaixa, M, Amigó, N, Correig, X, Kalko, S, Pomes, J, Novials, A. 01/06/2022. European Journal Of Applied Physiology. 122. PMID: 35298695. doi: 10.1007/s00421-022-04929-z

    Toxicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in early development: A wide-scope metabolomics assay in zebrafish embryos

    Merino, C, Casado, M, Piña, B, Vinaixa, M, Ramírez, N. 05/05/2022. Journal Of Hazardous Materials. 429. PMID: 35086039. doi: 10.1016/j.jhazmat.2021.127746

    Application of Machine Learning Solutions to Optimize Parameter Prediction to Enhance Automatic NMR Metabolite Profiling

    Cañueto, D, Salek, RM, Bulló, M, Correig, X, Cañellas, N. 01/04/2022. Metabolites. 12. PMID: 35448470. doi: 10.3390/metabo12040283

    Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

    Solomon, O, Huen, K, Yousefi, P, Küpers, LK, González, JR, Suderman, M, Reese, SE, Page, CM, Gruzieva, O, Rzehak, P, Gao, L, Bakulski, KM, Novoloaca, A, Allard, C, Pappa, I, Llambrich, M, Vives, M, Jima, DD, Kvist, T, Baccarelli, A, White, C, Rezwan, FI, Sharp, GC, Tindula, G, Bergström, A, Grote, V, Dou, JF, Isaevska, E, Magnus, MC, Corpeleijn, E, Perron, P, Jaddoe, VWV, Nohr, EA, Maitre, L, Foraster, M, Hoyo, C, Håberg, SE, Lahti, J, DeMeo, DL, Zhang, HM, Karmaus, W, Kull, I, Koletzko, B, Feinberg, JI, Gagliardi, L, Bouchard, L, Ramlau-Hansen, CH, Tiemeier, H, Santorelli, G, Maguire, RL, Czamara, D, Litonjua, AA, Langhendries, JP, Plusquin, M, Lepeule, J, Binder, EB, Verduci, E, Dwyer, T, Carracedo, A, Ferre, N, Eskenazi, B, Kogevinas, M, Nawrot, TS, Munthe-Kaas, MC, Herceg, Z, Relton, C, Melén, E, Gruszfeld, D, Breton, C, Fallin, MD, Ghantous, A, Nystad, W, Heude, B, Snieder, H, Hivert, MF, Felix, JF, Sorensen, TIA, Bustamante, M, Murphy, SK, Raikkönen, K, Oken, E, Holloway, JW, Arshad, SH, London, SJ, Holland, N. 01/03/2022. Mutation Research-Reviews In Mutation Research. 789. PMID: 35690418. doi: 10.1016/j.mrrev.2022.108415

    SALDI-MS and SERS Multimodal Imaging: One Nanostructured Substrate to Rule Them Both

    Iakab, SA, Baquer, G, Lafuente, M, Pina, MP, Ramírez, JL, Ràfols, P, Correig-Blanchar, X, García-Altares, M. 15/02/2022. Analytical Chemistry. 94. PMID: 35102738. doi: 10.1021/acs.analchem.1c04118

    Pathway-specific effects of ADSL deficiency on neurodevelopment

    Dutto, I, Gerhards, J, Herrera, A, Souckova, O, Skopová, V, Smak, JA, Junza, A, Yanes, O, Boeckx, C, Burkhalter, MD, Zikánová, M, Pons, S, Philipp, M, Lüders, J, Stracker, TH. 08/02/2022. eLife. 11. PMID: 35133277. doi: 10.7554/eLife.70518; 10.7554/eLife.70518.sa0; 10.7554/eLife.70518.sa1; 10.7554/eLife.70518.sa2

    A Modular and Expandable Ecosystem for Metabolomics Data Annotation in R

    Rainer, J, Vicini, A, Salzer, L, Stanstrup, J, Badia, JM, Neumann, S, Stravs, MA, Hernandes, VV, Gatto, L, Gibb, S, Witting, M. 01/02/2022. Metabolites. 12. PMID: 35208247. doi: 10.3390/metabo12020173

    Amanida: an R package for meta-analysis of metabolomics non-integral data

    Llambrich, M, Correig, E, Guma, J, Brezmes, J, Cumeras, R. 15/01/2022. BIOINFORMATICS. 38. PMID: 34406360. doi: 10.1093/bioinformatics/btab591

    Metabolite discovery: Biochemistry's scientific driver

    Giera, M, Yanes, O, Siuzdak, G. 04/01/2022. Cell Metabolism. 34. PMID: 34986335. doi: 10.1016/j.cmet.2021.11.005

    Proteomic profiling of skin associated ILC and T cells reveals functional differences

    Herraiz-Gil, S, Arriba, M, Martínez-Santamaría, L, Maseda, R, Illera, N, Yanes, O, Lwin, S, McGrath, JA, Escámez, M, Leon, C. 01/12/2022. Journal Of Investigative Dermatology. 142

    Responses of Mytilus galloprovincialis to challenge with environmental isolates of the potential emerging pathogen Malaciobacter marinus

    Auguste, M, Rahman, FU, Balbi, T, Leonessi, M, Oliveri, C, Bellese, G, Vezzulli, L, Furones, D, Canesi, L. 01/12/2022. Fish & Shellfish Immunology. 131. PMID: 36154890. doi: 10.1016/j.fsi.2022.09.048

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