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MoBioFood

MALALTIES METABÒLIQUES I NUTRICIÓ
NUTRICIÓ DIABETIS OBESITAT COLESTEROL
http://www.bioactivity-food.recerca.urv.cat
OBJECTIUS

L’objectiu del grup de recerca és estudiar la bioactivitat dels aliments a nivell del tracte gastrointestinal, es a dir, avaluar com diferents components de la nostra dieta poden afectar de manera adversa o beneficiosa el nostre intestí, i com aquesta interacció pot influenciar la salut de la resta de l’organisme. Dins les nostres línies d’estudi posem èmfasi en la caracterització a nivell molecular de la interacció de components de la dieta amb el sistema enteroendocrí, la capacitat d’aquests compostos de modificar la integritat de la barrera intestinal i el seu efecte immunomodulador, així com l’estudi d’alteracions de la microbiota intestinal provocades per certs aliments, l’anàlisi dels efectes epigenètics de diferents compostos bioactius en situacions d’estrès metabòlic com són l’obesitat o l’envelliment i l’estudi de l’efecte de fonts alternatives de proteïnes d’alta qualitat nutricional i més sostenibles mediambientals.

RESPONSABLES

  • Dra. Montse Pinent Armengol

  • Presentació
  • Línies de recerca
  • Projectes
  • Membres del grup
  • Publicacions
  • Contacte

El grup està format per doctores i doctors, estudiants de doctorat i personal tècnic que centrem els nostres estudis en descriure i entendre com els components bioactius dels aliments modulen el metabolisme i la salut, a través de les senyals enteroendocrines, els seus efectes sobre la gana i la seva activitat antiinflamatòria, principalment treballant a nivell del tracte gastrointestinal.

  • Estudi dels mecanismes de senyalització en cèl·lules endocrines i inflamatòries.
  • Bioactivitat de aliments en línies cel·lulars en cultiu i sistemes histotípics que mimetitzen la barrera gastrointestinal (sistemes de co-cultiu d’enteròcits i hepatòcits, cèl·lules beta i cèl·lules endotelials).
  • Estudis de funcionament de la paret gastrointestinal: Ussing Chambers, sistemes ex vivo.
  • Assajos de toxicitat de components de la dieta.
  • Treball en models animals (rata) d’obesitat, diabetis i inflamació. Estudis a nivell molecular mitjançant assajos d’activitat enzimàtica, expressió gènica (qPCR), expressió i quantificació de proteïnes (ELISA i immunoblotting), i tècniques Òmiques.

  • 2017-2019: 2017 SGR 289. Molecular Bioactivity of Food. Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR).

  • 2018-2021: Preventive long-lasting effects of food bioactives on gastrointestinal tract under metabolic homeostatic challenges: obesogenic diet and aging. AGL2017-83477-R. MINISTERIO DE ECONOMÍA Y COMPETITIVIDAD

  • Envelliment Saludable i Sostenible amb Proteïna d’Insecte (ESSARPI) Funding entity: Diputació de Tarragona Duration: 2020 – 2021 Principal Investigator: Maria Teresa Blay Olivé

    Año

    Dietary bioactive compounds modulating satiety and appetite: mechanisms of action.

    Casado-Hidalgo G, Pueyo-Arias M, Gil-Cardoso K, Les F, Mariné-Casadó R, Pinent M, Ardévol A, Lorente-Cebrián S, Capel F, Escoté X, Milagro FI, López V. 01/06/2026. Journal Of Physiology And Biochemistry. 82. PMID: 42219442. doi: 10.1007/s13105-026-01185-z

    From molecular mechanisms to nutritional applications: protein and polyphenol interventions in sarcopenia.

    Aragón-Espinosa P, Pérez-Matute P, Bompart C, Gueugneau M, Capel F, Arbones-Mainar JM, Gomez-Zorita S, Mas-Capdevila A, Escoté X, Pinent M, Ardévol A. 16/02/2026. Journal Of Physiology And Biochemistry. 82. PMID: 41697568. doi: 10.1007/s13105-026-01154-6

    Linking intestinal bitter taste receptors and GSPE-induced long-lasting benefits in ageing rats: an integrative analysis.

    Vilalta A, Descamps-Solà M, Sierra-Cruz M, Miguéns-Gómez A, Beltrán-Debón R, Rodríguez-Gallego E, Pinent M, Blay MT, Ardévol A, Terra X. 09/02/2026. Food & Function. 17. PMID: 41603721. doi: 10.1039/d5fo03241e

    Exploring the Role of TAS2Rs in Obesity: Insights From Human and Rat Models

    Descamps-Solà, M, Jalsevac, F, Vilalta, A, Fontcuberta, M, Park, H, Aguilar, C, Auguet, T, Beltrán-Debón, R, Rodríguez-Gallego, E, Pinent, M, Terra, X, Ardévol, A. 01/01/2026. Obesity. 34. PMID: 41140001. doi: 10.1002/oby.70055

    Assessment of the effects of soy varieties and processing on protein quality, digestibility and intestinal bioactivity (DPP-IV inhibition and total GLP-1 release)

    Accardo, F, Prandi, B, Tedeschi, T, Rodríguez-Gallego, E, Ardévol, A, Sforza, S, Pinent, M. 01/10/2025. Journal of Agriculture and Food Research. 23. doi: 10.1016/j.jafr.2025.102215

    Grape Seed Proanthocyanidins: A Potential Microbiome-Targeted Intervention for Healthy Aging in Rats.

    Sierra-Cruz M, Vilalta A, Miguéns-Gómez A, Park H, Rodríguez-Gallego E, Blay MT, Ardévol A, Pinent M, Behmoaras J, Beltrán-Debón R, Terra X. 01/09/2025. Molecular Nutrition & Food Research. 69. PMID: 40534245. doi: 10.1002/mnfr.70150

    TAS2R5 and TAS2R38 are bitter taste receptors whose colonic expressions could play important roles in age-associated processes

    Jalsevac, F, Segú, H, Balaguer, F, Ocaña, T, Moreira, R, Abad-Jordà, L, Gràcia-Sancho, J, Fernàndez-Iglesias, A, Andres-Lacueva, C, Martínez-Huélamo, M, Beltran-Debon, R, Rodríguez-Gallego, E, Terra, X, Ardévol, A, Pinent, M. 01/06/2025. Journal Of Nutritional Biochemistry. 140. PMID: 39986633. doi: 10.1016/j.jnutbio.2025.109872

    Protective effects of grape seed procyanidin extract on neurotrophic and muscarinic signaling pathways in the aging neuromuscular junction.

    Balanyà-Segura M, Polishchuk A, Just-Borràs L, Cilleros-Mañé V, Silvera C, Jami-ElHirchi M, Pinent M, Ardévol A, Tomàs M, Lanuza MA, Hurtado E, Tomàs J. 06/05/2025. Food & Function. 16. PMID: 40231589. doi: 10.1039/d5fo00286a

    Syntheses of differentially fluorinated triazole-based 1-deoxysphingosine analogues en route to SphK inhibitors.

    Cardona A, Ivanova V, Beltrán-Debón R, Barril X, Castillón S, Díaz Y, Matheu MI. 29/01/2025. Organic & Biomolecular Chemistry. 23. PMID: 39565065. doi: 10.1039/d4ob01656d

    Survivin/BIRC5 as a novel molecular effector at the crossroads of glucose metabolism and radioresistance in head and neck squamous cell carcinoma

    Benaiges, E, Ceperuelo-Mallafré, V, Guaita, S, Maymó-Masip, E, Madeira, A, Gómez, D, Hernández, V, Vilaseca, I, Merma, C, León, X, Terra, X, Vendrell, J, Avilés-Jurado, FX, Fernández-Veledo, S. 02/02/2024. Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck. 46. PMID: 38305029. doi: 10.1002/hed.27651

    Transcriptional expression of SLC16A7 as a biomarker of occult lymph node metastases in patients with head and neck squamous cell carcinoma

    Camacho, M, Vazquez-López, C, Valero, C, Holgado, A, Terra, X, Avilés-Jurado, FX, León, X. 01/12/2024. European Archives Of Oto-Rhino-Laryngology. 281. PMID: 39215860. doi: 10.1007/s00405-024-08882-9

    Grape-Seed Proanthocyanidin Extract (GSPE) Modulates Diurnal Rhythms of Hepatic Metabolic Genes and Metabolites, and Reduces Lipid Deposition in Cafeteria-Fed Rats in a Time-of-Day-Dependent Manner

    Rodríguez, RM, de Assis, LVM, Calvo, E, Colom-Pellicer, M, Quesada-Vázquez, S, Cruz-Carrión, A, Escoté, X, Oster, H, Aragonès, G, Mulero, M. 01/12/2024. Molecular Nutrition & Food Research. 68. PMID: 39523911. doi: 10.1002/mnfr.202400554

    Profiling bitter taste receptors (TAS2R) along the gastrointestinal tract and their influence on enterohormone secretion. Gender- and age-related effects in the colon

    Jalsevac, F, Descamps-Solà, M, Grau-Bové, C, Segú, H, Auguet, T, Avilés-Jurado, FX, Balaguer, F, Jorba, R, Beltrán-Debón, R, Blay, MT, Barbadora, XT, Pinent, M, Ardévol, A. 17/10/2024. Frontiers in endocrinology. 15. PMID: 39512758. doi: 10.3389/fendo.2024.1436580

    Molecular Adaptations of BDNF/NT-4 Neurotrophic and Muscarinic Pathways in Ageing Neuromuscular Synapses

    Balanyà-Segura, M, Polishchuk, A, Just-Borràs, L, Cilleros-Mañé, V, Silvera, C, Ardévol, A, Tomàs, M, Lanuza, MA, Hurtado, E, Tomàs, J. 01/08/2024. International Journal Of Molecular Sciences. 25. PMID: 39125587. doi: 10.3390/ijms25158018

    Assessing the impact of insect protein sources on intestinal health and disease: insights from human ex vivo and rat in vivo models

    Segú, H, Jalsevac, F, Sierra-Cruz, M, Feliu, F, Movassat, J, Rodríguez-Gallego, E, Terra, X, Pinent, M, Ardévol, A, Blay, MT. 22/04/2024. Food & Function. 15. PMID: 38584501. doi: 10.1039/d4fo00381k

    Vitis vinifera L. Bioactive Components Modulate Adipose Tissue Metabolic Markers of Healthy Rats in a Photoperiod-Dependent Manner.

    Navarro-Masip È, Manocchio F, Colom-Pellicer M, Escoté X, Iglesias-Carres L, Calvo E, Bravo FI, Muguerza B, Desjardins Y, Aragonès G. 01/09/2023. Molecular Nutrition & Food Research. 67. PMID: 37421210. doi: 10.1002/mnfr.202300074

    GSPE Pre-Treatment Exerts Long-Lasting Preventive Effects against Aging-Induced Changes in the Colonic Enterohormone Profile of Female Rats

    Miguéns-Gómez, A, Sierra-Cruz, M, Blay, MT, Rodríguez-Gallego, E, Beltrán-Debón, R, Terra, X, Pinent, M, Ardévol, A. 25/04/2023. International Journal Of Molecular Sciences. 24. PMID: 37175514. doi: 10.3390/ijms24097807

    Administration of Alphitobius diaperinus or Tenebrio molitor before meals transiently increases food intake through enterohormone regulation in female rats

    Miguéns-Gómez, A, Sierra-Cruz, M, Segú, H, Beltrán-Debón, R, Rodríguez-Gallego, E, Terra, X, Blay, MT, Pérez-Vendrell, AM, Pinent, M, Ardévol, A. 15/03/2023. Journal Of The Science Of Food And Agriculture. 103. PMID: 36324158. doi: 10.1002/jsfa.12305

    Grape-Seed Proanthocyanidins Modulate Adipose Tissue Adaptations to Obesity in a Photoperiod-Dependent Manner in Fischer 344 Rats

    Navarro-Masip, E, Colom-Pellicer, M, Manocchio, F, Arola-Arnal, A, Bravo, FI, Muguerza, B, Aragonès, G. 01/02/2023. Nutrients. 15. PMID: 36839395. doi: 10.3390/nu15041037

    Relationship between transcriptional expression of pyruvate dehydrogenase and local control of disease in patients with oral cavity carcinomas

    León, X, Bague, S, Holgado, A, Quer, M, Terra, X, Camacho, M, Aviltes-Jurado, FX. 01/11/2023. Acta Otorrinolaringologica Espanola. 74. doi: 10.1016/j.otorri.2023.05.001

    Bitter taste receptors along the gastrointestinal tract: comparison between humans and rodents

    Descamps-Solà, M, Vilalta, A, Jalsevac, F, Blay, MT, Rodríguez-Gallego, E, Pinent, M, Beltrán-Debón, R, Terra, X, Ardévol, A. 30/08/2023. Frontiers In Nutrition. 10. PMID: 37712001. doi: 10.3389/fnut.2023.1215889

    Effects of grape seed proanthocyanidin extract on lipopolysaccharide translocation and trafficking from the gut to tissues

    Sierra-Cruz, M, Miguéns-Gómez, A, Rodríguez-Gallego, E, D’Addario, C, Di Bartolomeo, M, Blay, MT, Pinent, M, Beltrán-Debón, R, Terra, X. 01/06/2023. Journal Of Functional Foods. 105. doi: 10.1016/j.jff.2023.105566

    Inhibition of DPP-IV Activity and Stimulation of GLP-1 Release by Gastrointestinally Digested Black Soldier Fly Prepupae

    Luparelli, A, Miguéns-Gómez, A, Ardévol, A, Sforza, S, Caligiani, A, Pinent, M. 17/05/2023. Foods. 12. PMID: 37238845. doi: 10.3390/foods12102027

    GSPE pre-treatment protects against long-term cafeteria diet-induced mitochondrial and inflammatory affectations in the hippocampus of rats.

    Busquets O, Carrasco M, Espinosa-Jiménez T, Ettcheto M, Verdaguer E, Auladell C, Bullò M, Camins A, Pinent M, Rodríguez-Gallego E, Folch J. 01/12/2022. NUTRITIONAL NEUROSCIENCE. 25. PMID: 34789070. doi: 10.1080/1028415X.2021.1995118

    Prognostic capacity of the transcriptional expression of lactate dehydrogenase A in patients with head and neck squamous cell carcinoma

    Bagué, S, León, X, Terra, X, Lejeune, M, Camacho, M, Avilés-Jurado, FX. 01/11/2022. Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck. 44. PMID: 36207788. doi: 10.1002/hed.27161

    Differential effects of a cafeteria diet and GSPE preventive treatments on the enterohormone secretions of aged vs. young female rats

    Miguéns-Gómez, A, Sierra-Cruz, M, Pérez-Vendrell, AM, Rodríguez-Gallego, E, Beltrán-Debón, R, Terra, X, Ardévol, A, Pinent, M. 17/10/2022. Food & Function. 13. PMID: 36148543. doi: 10.1039/d2fo02111k

    Carvedilol plus Simvastatin modulates systemic inflammation in cirrhosis with portal hypertension and non-response to B-blockers: randomised double-blind study

    Alvarado-Tapias, E, Montanes, R, Brujats, A, Cuyas, B, Guix, MG, Pujol, C, Murzi-Pulgar, M, Poca, M, Graupera, I, Pavel, O, Ardevol, A, Torras, X, Roig, PB, Escorsell, A, Vidal, S, Villanueva, C. 01/07/2022. Journal Of Hepatology. 77

    Intestinal Morphometric Changes Induced by a Western-Style Diet in Wistar Rats and GSPE Counter-Regulatory Effect

    Segú, H, Jalsevac, F, Pinent, M, Ardévol, A, Terra, X, Blay, MT. 01/07/2022. Nutrients. 14. PMID: 35807788. doi: 10.3390/nu14132608

    Semaphorin-3F/Neuropilin-2 Transcriptional Expression as a Predictive Biomarker of Occult Lymph Node Metastases in HNSCC

    Meler-Claramonte, C, Avilés-Jurado, FX, Vilaseca, I, Terra, X, Bragado, P, Fuster, G, Vintró, XL, Camacho, M. 01/05/2022. Cancers. 14. PMID: 35565388. doi: 10.3390/cancers14092259

    Application of emerging technologies to obtain legume protein isolates with improved techno-functional properties and health effects

    Bou, R, Navarro-Vozmediano, P, Domínguez, R, López-Gómez, M, Pinent, M, Ribas-Agustí, A, Benedito, JJ, Lorenzo, JM, Terra, X, Garcia-Perez, JV, Pateiro, M, Herrera-Cervera, JA, Jorba-Martín, R. 01/05/2022. Comprehensive Reviews In Food Science And Food Safety. 21. PMID: 35340098. doi: 10.1111/1541-4337.12936

    Effect of an Acute Insect Preload vs. an Almond Preload on Energy Intake, Subjective Food Consumption and Intestinal Health in Healthy Young Adults

    Miguéns-Gómez, A, Sierra-Cruz, M, Rodríguez-Gallego, E, Beltrán-Debón, R, Blay, MT, Terra, X, Pinent, M, Ardévol, A. 01/04/2022. Nutrients. 14. PMID: 35406076. doi: 10.3390/nu14071463

    GLP1 Exerts Paracrine Activity in the Intestinal Lumen of Human Colon

    Grau-Bové, C, González-Quilen, C, Cantini, G, Nardini, P, Espina, B, Bani, D, Terra, X, Blay, M, Rodríguez-Gallego, E, Luconi, M, Ardévol, A, Pinent, M. 01/04/2022. International Journal Of Molecular Sciences. 23. PMID: 35408884. doi: 10.3390/ijms23073523

    Revealing 2-dimethylhydrazino-2-alkyl alkynyl sphingosine derivatives as sphingosine kinase 2 inhibitors: Some hints on the structural basis for selective inhibition

    Corro-Morón, M, Granell, A, Ivanova, V, Domingo, E, Beltrán-Debón, R, Barril, X, Sanz, MJ, Matheu, MI, Castillón, S, Díaz, Y. 01/04/2022. Bioorganic Chemistry. 121. PMID: 35219046. doi: 10.1016/j.bioorg.2022.105668

    The Hidden One: What We Know About Bitter Taste Receptor 39

    Jalsevac, F, Terra, X, Rodriguez-Gallego, E, Beltran-Debón, R, Blay, MT, Pinent, M, Ardévol, A. 08/03/2022. Frontiers in endocrinology. 13. PMID: 35345470. doi: 10.3389/fendo.2022.854718

    Functional and genomic comparative study of the bitter taste receptor family TAS2R: Insight into the role of human TAS2R5

    Grau-Bové, C, Grau-Bové, X, Terra, X, Garcia-Vallve, S, Rodríguez-Gallego, E, Beltran-Debón, R, Blay, MT, Ardévol, A, Pinent, M. 01/03/2022. Faseb Journal. 36. PMID: 35107858. doi: 10.1096/fj.202101128RR

    Resistin and IL-15 as Predictors of Invasive Mechanical Ventilation in COVID-19 Pneumonia Irrespective of the Presence of Obesity and Metabolic Syndrome

    Perpiñan, C, Bertran, L, Terra, X, Aguilar, C, Binetti, J, Lopez-Dupla, M, Rull, A, Reverté, L, Yeregui, E, Gómez-Bertomeu, F, Peraire, J, Auguet, T. 01/03/2022. Journal of personalized medicine. 12. PMID: 35330391. doi: 10.3390/jpm12030391

    Lipocalin, Resistin and Gut Microbiota-Derived Propionate Could Be Used to Predict Metabolic Bariatric Surgery Selected Outcomes

    Auguet, T, Lopez-Dupla, M, Ramos, J, Bertran, L, Riesco, D, Aguilar, C, Ardévol, A, Pinent, M, Sabench, F, Del Castillo, D, Richart, C. 01/01/2022. Processes. 10. doi: 10.3390/pr10010143

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