Presentació dels Hospitals
Col·labora

Unitat de Recerca en Lípids i Arteriosclerosi i Unitat de Medicina Vascular i Metabolisme (URLA-UVASMET)

MALALTIES METABÒLIQUES I NUTRICIÓ
NUTRICIÓ DIABETIS OBESITAT COLESTEROL
OBJECTIUS

La Unitat de Recerca en Lípids i Arteriosclerosi es va crear el 1985. Hi treballen 18 persones (5 clínics UVASMET). L’objectiu del grup és la recerca dels trastorns del metabolisme lipídic i l’activitat docent. És un grup de recerca consolidat per la Generalitat de Catalunya, forma part del CIBERDEM, de l’IRB CatSud i de la URV. Les línies de recerca principals són: Hipercolesterolèmia Familiar; bases moleculars de la dislipèmia aterògena; genètica i epigenètica dels trastorns lipídics.

 

RESPONSABLES

  • Dr. Josep Ribalta Vives

  • Dra. Daiana Ibarretxe Guerediaga

  • Presentació
  • Línies de recerca
  • Projectes
  • Membres del grup
  • Transferència
  • Difusió
  • Publicacions
  • Contacte

La Unitat de Medicina Vascular i Metabolisme (UVASMET) té com a objectiu el diagnòstic i tractament de les alteracions severes del metabolisme lipídic i la hipertensió arterial com a mesures preventives de les seves conseqüències patològiques, en primer terme les malalties cardiovasculars, que continuen sent la primera causa de mortalitat al nostre país, però també les malalties pancreàtiques, hepàtiques, renals, associades a les alteracions del metabolisme lipídic.

En què som experts i ens quins àmbits podem col·laborar?

  • Assaig clínics en pacients afectes de dislipèmies, risc cardiovascular i altres.
  • Estudis avançats del metabolisme lipídic, inclosa la 1H-RNM de lipoproteïnes (Liposcale- www.biosferteslab.com)
  • Aïllament de lipoproteïnes per ultracentrifugació.
  • Biomarcadors de malalties metabòliques i inflamatòries.
  • Estudis genètics i epigenètics
  • Estudis de miRNA
  • Tècniques bàsiques de laboratori.
  • Cultius cel·lulars
  • Tècniques de biologia molècula

La recerca s’organitza de forma coordinada entre ambdues Unitats: URLA-UVASMET
Director: Lluís Masana
Co-Director URLA: Josep Ribalta

La recerca de la URLA s’organitza en les següents línies, sota la responsabilitat d’un investigador principal (IP):

  • Hipercolesterolèmia Familiar.
    Responsables: Lluís Masana i Núria Plana.
  • Metabolisme lipoproteic, arteriosclerosi, diabetis.
    Responsables: Lluís Masana i   Josefa Girona.
  • Miocardiopatia diabètica
    Responsable: Ricardo Rodríguez
  • Vesícules extracel·lulars i malalties cardiovasculars i metabòliques
    Responsable: Neus Martínez-Micaelo
  • Característiques aterogèniques de les lipoproteïnes
    Responsable: Josep Ribalta
  • Genètica i epigenètica de les dislipèmies i risc vascular
    Responsable: Montse Guardiola
  • Dislipèmia, paret vascular i malalties reumatològiques
    Responsable: Joan Carles Vallvé
  • Metabolisme lipídic i càncer (col·laboració amb Oncologia)
    Responsable: Sandra Guaita (Grup de Recerca Oncològica)

  • Title: Donación_ lipidómica serica mediante 1 h-rmn en la detección y prevención de la preeclampsia: reclama.

    Funding entity: FUNDACION ESPAÑOLA DE ARTERIOESCLEROSIS

    Duration: 2027-2028

    Principal Investigator: IBARRETXE GEREDIAGA, DAIANA

  • Title: Ayuda fea 2024 – de las becas de nutricion “manuel de oya’: evaluacion del estado metabolomico-nutricional y riesgo cardiovascular en adolescentes con anorexia nerviosa y bajo peso corporal.”.

    Funding entity: FUNDACION ESPAÑOLA DE ARTERIOESCLEROSIS

    Duration: 2025-2027

    Principal Investigator: FELIU ROVIRA, ALBERT

  • Title: Mecanismos implicados en la inhibición de fabp4: análisis de las vías terapéuticas en los trastornos metabólicos relacionados con la obesidad (fit)

    Funding entity: AGENCIA ESTATAL DE INVESTIGACION

    Duration: 2025-2030

    Principal Investigator: GIRONA TELL, JOSEFA

    Investigators: ESTEBAN MORENO, MARIA YAIZA; GAVALDA ALSINA, GEMMA; REHUES MASIP, PERE; RODRIGUEZ CALVO, RICARDO

  • Title: Un panel de biomarcadores de lipoproteinas no relacionadas con el colesterol para la deteccion temprana de la propagacion rapida de la aterosclerosis en sujetos con colesterol ldl normal

    Funding entity: INSTITUTO CARLOS III

    Duration: 2025-2029

    Principal Investigator: RIBALTA VIVES, JOSEP

    Investigators: ANDREYCHUK PASICHNA, NATALIA; ESTEBAN MORENO, MARIA YAIZA; GONZÁLEZ LLEÓ, ANNA MARIA; GUARDIOLA GUIONNET, MONTSERRAT; VIDAL ROMERO, ANNA

  • Title: Lipo y glicoproteinas por rmn en niños con hipercolesterolemia familiar.

    Funding entity: INSTITUTO CARLOS III

    Duration: 2023-2028

    Principal Investigator: RODRIGUEZ BORJABAD, CELIA

    Investigators: LLOP PAREDES, DÍDAC; MASANA MARIN, LLUIS; PIJUAN CAMPOS, JULIA; PLANA GIL, NÚRIA

  • Title: Pi21/01294 ‘ estudio clinico e in vitro de las glicoformas de apoc-iii asociadas a lipoproteinas como biomarcadores de diabetes y su asociacion con el riesgo cardiovascular en la cohorte prospectiva di@betes ‘

    Funding entity: INSTITUTO CARLOS III

    Duration: 2022-2027

    Principal Investigator: RIBALTA VIVES, JOSEP

    Investigators: , RIBALTA VIVES, JOSEP

  • Title: 2021 sgr 00815 grup de recerca consolidat (grc) opicio finançament competitiu (avluacio cientifica) urv-iispv

    Funding entity: AGENCIA DE GESTIO D’AJUTS UNIVERSITARIS I DE RECERCA

    Duration: 2022-2027

    Principal Investigator: RIBALTA VIVES, JOSEP

  • Inventors/es (per ordre de signatura): Mallol Parera, Roger; Amigó Grau, Núria; Correig Blanchar, Xavier; Masana Marín, Lluís; Rodríguez Martínez, Miguel Ángel; Heras Ibáñez, Mercedes; Plana Gil, Núria.

    Títol:  Methods for determining the lipid distribution between the core and the shell of a lipoprotein particle.

    Núm. de sol·licitud: EP13382477.1 País de prioritat: EPO Data de prioritat: 27/11/2013

    Entitat titular: Universitat Rovira i Virgili (URV) i Fundació Institut d’Investigació Sanitària Pere Virgili (IISPV).

    Empreses que l’exploten: BIOSFER TESLAB, SL

  • Inventors/es (per ordre de signatura):  Mallol Parera, Roger; Amigó Grau, Núria; Correig Blanchar, Xavier; Masana Marín, Lluís; Rodríguez Martínez, Miguel Ángel; Heras Ibáñez, Mercedes; Plana Gil, Núria;  Ribalta Vives, Josep.

    Títol: Method for the characterization of lipoproteins.

    Núm. de sol·licitud: EP12382478.9 País de prioritat: EPO Data de prioritat: 27/11/2013

    Entitat titular: Universitat Rovira i Virgili (URV) i Fundació Institut d’Investigació Sanitària Pere Virgili (IISPV)

    Empreses que l’exploten: BIOSFER TESLAB, SL

  • CONSTITUCIÓ SPIN-OFF

    Participació com a soci de l’EBT Spin-off BIOSFER TESLAB, SL, constituïda davant notari el 20/12/2013 amb número de protocol: 2105. Societat mercantil participada per les institucions: Universitat Rovira i Virgili i la Fundació Institut d’Investigació Sanitària Pere Virgili.

    Año

    Multiomics for Risk Stratification in Atherosclerotic Cardiovascular Disease.

    Nordestgaard LT, Magni P, Sopic M, Chemaly M, Matic L, Dalila N, Trindade F, Wolford BN, Rodriguez-Hernandez Z, Amigó N, Catapano AL, Masana L, Devaux Y. 01/04/2026. Circulation-Genomic and Precision Medicine. 19. PMID: 41878824. doi: 10.1161/CIRCGEN.125.005451

    Assessment of physical status and analysis of lipidomic and metabolomic alterations in patients with Post-COVID-19 condition.

    Pavón R, Parra S, Rubio FJ, Feliu M, Ríos M, Iftimie S, Rovira C, Amigó N, Cabau L, Martínez-Micaelo N, Castro A. 03/03/2026. Plos One. 21. PMID: 41774679. doi: 10.1371/journal.pone.0341192

    SEA 2026 Standards for Global Control of Vascular Risk.

    Mostaza JM, Pintó X, Armario P, Guijarro C, Masana L, Real JT, Arrobas-Velilla T, Baeza-Trinidad R, Calmarza P, Cebollada J, Civera-Andrés M, Cuende Melero JI, Díaz-Díaz JL, Fernández Pardo J, Jericó C, Lahoz C, López-Melgar B, López-Miranda J, Martínez-Hervás S, Muñiz-Grijalvo O, Páramo JA, Pascual V, Pedro-Botet J, Pérez-Martínez P, Puzo J, Tamarit JJ. 01/03/2026. CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS. 38. PMID: 41633912. doi: 10.1016/j.arteri.2025.500889

    Inclisiran for children: is it worth it?

    Masana L, Ibarretxe D. 01/03/2026. Lancet Diabetes & Endocrinology. 14. PMID: 41616800. doi: 10.1016/S2213-8587(25)00367-5

    Targeting Atherosclerosis: Cholesterol-Lowering Therapies with a New Immunometabolic Dress for an Old Disease

    Julve, J, Rodriguez-Calvo, R, Perret, B, Martinez, LO, Mauricio, D. 11/12/2025. Journal of clinical medicine. 14. PMID: 41464678. doi: 10.3390/jcm14248777

    A Robust Multivariate Approach Unveils a 1H-NMR-Based Spectral Metabolomics Signature Predictive of Cardiovascular Disease in People with Type 2 Diabetes: A Prospective Di@bet.es Cohort Study

    Rehues, P, Guardiola, M, Amigo, N, Rojo-Martinez, G, Mallol-Parera, R, Ribalta, J. 05/12/2025. Journal Of Proteome Research. 24. PMID: 41258650. doi: 10.1021/acs.jproteome.5c00662

    Widespread lipoprotein alterations in a REDUCE-IT like population: The icosapent ethyl (IPE)-NMR avatar study

    Masana, L, Torné, P, Garcia-Moll, X, Dalli, E, Amigo, N. 01/11/2025. Nutrition Metabolism And Cardiovascular Diseases. 35. PMID: 40651885. doi: 10.1016/j.numecd.2025.104199

    Prognostic stratification of familial hypercholesterolaemia patients using AI algorithms: a gender-specific approach

    Zamora, A, Masana, L, Civeira, F, Ibarretxe, D, Fanlo-Maresma, M, Vila, A, Tembra, MS, Marco-Benedí, V, Alvarez-Sala-Walther, LA, Camacho-Ruiz, M. 01/11/2025. European Heart Journal – Digital Health. 6. PMID: 41267838. doi: 10.1093/ehjdh/ztaf092

    The multiomics blueprint of the individual with the most extreme lifespan

    Santos-Pujol, E, Noguera-Castells, A, Casado-Pelaez, M, García-Prieto, CA, Vasallo, C, Campillo-Marcos, I, Quero-Dotor, C, Crespo-García, E, Bueno-Costa, A, Setién, F, Ferrer, G, Davalos, V, Mereu, E, Pluvinet, R, Arribas, C, de la Torre, C, Villavicencio, F, Sumoy, L, Granada, I, Coles, NS, Acha, P, Solé, F, Mallo, M, Mata, C, Peregrina, S, Gabaldón, T, Llirós, M, Pujolassos, M, Carreras-Torres, R, Lluansí, A, García-Gil, LJ, Aldeguer, X, Samino, S, Torné, P, Ribalta, J, Guardiola, M, Amigó, N, Yanes, O, Martínez, P, Sánchez-Vásquez, R, Blasco, MA, Oviedo, J, Lemos, B, Rius-Bonet, J, Torrubiano, M, Massip-Salcedo, M, Khidir, KA, Cao, TH, Quinn, PA, Jones, DJL, Macip, S, Brigos-Barril, E, Moldes, M, Barteri, F, Muntané, G, Laayouni, H, Navarro, A, Esteller, M. 21/10/2025. Cell Reports Medicine. 6. PMID: 40997805. doi: 10.1016/j.xcrm.2025.102368

    Atherosclerotic cardiovascular disease and mortality in a cohort of patients with rheumatoid arthritis: a prospective study investigating microRNAs as predictors of atherosclerosis and mortality

    Llop, D, Paredes, S, Ibarretxe, D, Rosales, R, Masana, L, Ribalta, J, Vallvé, JC. 08/10/2025. Frontiers in immunology. 16. PMID: 41132650. doi: 10.3389/fimmu.2025.1667553

    Sudden death in a homozygous familial hypercholesterolemic child with noncompaction cardiomyopathy. Just a coincidence?

    Ibarretxe-Guerediaga, D, Marimon, C, Feliu, A, Rodríguez-Borjabad, C, Plana, N, Masana, L. 01/10/2025. REVISTA ESPANOLA DE CARDIOLOGIA. 78. PMID: 39929344. doi: 10.1016/j.rec.2025.01.016

    Multiomics in atherosclerotic cardiovascular disease

    Nordestgaard, LT, Wolford, BN, de Gonzalo-Calvo, D, Sopic, M, Devaux, Y, Matic, L, Wettinger, SB, Schmid, JA, Amigó, N, Masana, L, Catapano, AL, Kardassis, D, Magni, P. 01/09/2025. Atherosclerosis. 408. PMID: 40663987. doi: 10.1016/j.atherosclerosis.2025.120414

    Triglycerides as Determinants of Global Lipoprotein Derangement: Implications for Cardiovascular Prevention

    Amigó, N, Torne, P, Nordestgaard, LT, Di Giacomo-Barbagallo, F, Merino, C, Magni, P, González-Lleó, A, Andreychuk, N, Catapano, AL, Masana, L, Ibarretxe, D. 26/08/2025. International Journal Of Molecular Sciences. 26. PMID: 40943205. doi: 10.3390/ijms26178284

    Serum Growth Differentiation Factor 15 (GDF15) Levels Reflect Ischemic Etiology in Heart Failure Patients with Iron Deficiency: A Cross-Sectional Study

    Tajes, M, Ras-Jimenez, MD, Girona, J, Ramos-Polo, R, Guardiola, M, Garcia-Pinilla, JM, Ribalta, J, Cobo-Marcos, M, Masana, L, de Juan-Bagudá, J, Fonseca, C, Enjuanes, C, Vázquez-Carrera, M, Comin-Colet, J, Rodriguez-Calvo, R. 26/08/2025. Biomolecules. 15. PMID: 41008541. doi: 10.3390/biom15091234

    Age-related and sex-related increase in Lp(a). Role of triglycerides

    Benedi, VM, Laclaustra, M, Bea, AM, Tembra, MS, Plana, N, Pinto, X, Vila, A, Civeira, F. 01/08/2025. Atherosclerosis. 407

    Efficacy, safety, and tolerability of antifibrotic agents in rheumatoid arthritis-associated interstitial lung disease: A systematic review and meta-analysis

    Narváez, J, Aguilar-Coll, M, Roig-Kim, M, Palacios-Olid, J, Maymó-Paituvi, P, de Daniel-Bisbe, L, Llop, D. 30/05/2025. Autoimmunity Reviews. 24. PMID: 40089094. doi: 10.1016/j.autrev.2025.103804

    Plasma expression of a microRNA panel is differentially associated with 1H-NMR lipoprotein profile in rheumatoid arthritis patients

    Llop, D, Paredes, S, Rosales, R, Ribalta, J, Vallvé, JC. 01/05/2025. CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS. 37. PMID: 39884918. doi: 10.1016/j.arteri.2025.500759

    New Cardiovascular Risk Biomarkers in Rheumatoid Arthritis: Implications and Clinical Utility-A Narrative Review

    Pamies, A, Vallvé, JC, Paredes, S. 03/04/2025. Biomedicines. 13. PMID: 40299461. doi: 10.3390/biomedicines13040870

    Advancing atherosclerosis research: The Power of lipid imaging with MALDI-MSI

    Bookmeyer, CHM, Correig, FX, Masana, L, Magni, P, Yanes, O, Vinaixa, M. 01/04/2025. Atherosclerosis. 403. PMID: 40059002. doi: 10.1016/j.atherosclerosis.2025.119130

    Familial Combined Hyperlipidemia: Myth or Reality?

    Brouwers, MCGJ, Klop, B, Ribalta, J, Cabezas, MC. 01/04/2025. Current Atherosclerosis Reports. 27. PMID: 40167575. doi: 10.1007/s11883-025-01289-9

    Evaluation of glycemic status and subclinical atherosclerosis in familial hypercholesterolemia subjects with or without LDL receptor mutation

    Barbagallo, FD, Bosco, G, Di Marco, M, Scilletta, S, Miano, N, Musmeci, M, Martedi, M, González-Lleó, AM, Ibarretxe, D, De Francesco, EM, Malaguarnera, R, Di Pino, A, Masana, L, Purrello, F, Piro, S, Scicali, R. 20/03/2025. Cardiovascular Diabetology. 24. PMID: 40114220. doi: 10.1186/s12933-025-02683-y

    GDF15 Circulating Levels Are Associated with Metabolic-Associated Liver Injury and Atherosclerotic Cardiovascular Disease

    Girona, J, Guardiola, M, Barroso, E, García-Altares, M, Ibarretxe, D, Plana, N, Ribalta, J, Amigó, N, Correig, X, Vázquez-Carrera, M, Masana, L, Rodríguez-Calvo, R. 01/03/2025. International Journal Of Molecular Sciences. 26. PMID: 40076667. doi: 10.3390/ijms26052039

    Advanced serum lipoprotein and glycoprotein profiling for cardiovascular event prediction in type 2 diabetes mellitus: the LIPOCAT study

    Amigó, N, Castelblanco, E, Julve, J, Martínez-Micaelo, N, Alonso, N, Hernández, M, Ribalta, J, Guardiola, M, Torán-Monserrat, P, Lopez-Lifante, V, Herrero-Alonso, C, Arteaga, I, Ortega, E, Franch-Nadal, J, Mauricio, D. 21/02/2025. Cardiovascular Diabetology. 24. PMID: 39985069. doi: 10.1186/s12933-025-02636-5

    Evaluations of metabolic and innate immunity profiles in subjects with familial hypercholesterolemia with or without subclinical atherosclerosis.

    Bosco G, Di Giacomo Barbagallo F, Di Marco M, Scilletta S, Miano N, Capuccio S, Musmeci M, Di Mauro S, Filippello A, Scamporrino A, Di Pino A, Masana L, Purrello F, Piro S, Scicali R. 01/02/2025. European Journal Of Internal Medicine. 132. PMID: 39672731. doi: 10.1016/j.ejim.2024.12.002

    Lipid-lowering drug therapy for reducing cardiovascular risk in diabetes. A clinical view of the Cardiovascular Disease Working Group of the Spanish Diabetes Society

    Pedro-Botet, J, Arrieta, F, Botana, M, Gimeno-Orna, JA, Martinez-Montoro, JI, de Victoria, EOM, Ribalta, J, Sánchez-Margalet, V, Pérez-Pérez, A. 01/02/2025. ENDOCRINOLOGIA DIABETES Y NUTRICION. 72. PMID: 39924389. doi: 10.1016/j.endien.2025.101523

    Triglyceride-independent associations between circulating levels of apolipoprotein C-III and biomarkers of inflammation

    Llop, D, Rehues, P, Paredes, S, Guardiola, M, Girona, J, Rosales, R, Esteban, Y, Masana, L, Ibarretxe, D, Vallvé, JC, Ribalta, J. 08/01/2025. Cardiovascular Diabetology. 24. PMID: 39780204. doi: 10.1186/s12933-024-02553-z

    The CNIC polypill (Acetylsalicylic acid plus Atorvastatin plus Rampril) in secondary prevention of cardiovascular disease in patients with type 2 diabetes: A comparative analysis with alternative therapeutic approaches

    González-Juanatey, JR, Masana, L, Dalmau, R, Cordero, A. 01/01/2025. International Journal Of Cardiology. 418. PMID: 39306297. doi: 10.1016/j.ijcard.2024.132578

    Usage of lipid-lowering therapies in patients at high and very high cardiovascular risk from Spain: one-year follow-up of the Spanish subpopulation from the European SANTORINI study.

    Mostaza JM, Lahoz C, de Yébenes Castro MG, Rubio Campal JM, Velásquez E, Ibarra Gutiérrez A, Díaz JF, Plana N, Rodríguez-Mañero M, de Dios García-Díaz J, Martínez Debén F, Pavón de Paz I, Catapano AL, Díaz Moya G, Ray KK. 01/10/2025. Revista clínica espanõla. 225. PMID: 40675328. doi: 10.1016/j.rceng.2025.502344

    Microbiota Shape Metabolic and Immune Determinants of CAR-T Therapy and Correlate with Outcomes in Myeloma

    Uribe-Herranz, M, Oliver-Caldés, A, Martínez-Micaelo, N, Español-Rego, M, Val-Casals, M, Martínez-Soler, R, Rubio-Garcia, E, Brunello, V, Mihelic, EZ, Klein-González, N, Benítez-Ribas, D, Amigó, N, Vergara, A, Ortiz-Maldonado, V, Rodríguez-Lobato, LG, Delgado, J, de Landazuri, IO, González-Calle, V, Cabañas, V, Martin-Antonio, B, Pérez-Amill, L, Reguera-Ortega, JL, Rodríguez-Otero, P, Paiva, B, Martínez-López, J, Mateos, MV, Pascal, M, Urbano-Ispizua, A, González-Navarro, EA, de Larrea, CF, Juan, ME. 03/09/2025. Blood cancer discovery. 6. PMID: 40643584. doi: 10.1158/2643-3230.BCD-24-0203

    apoC-III proteoforms are associated with better lipid, inflammatory, and glucose profiles

    Rehues, P, Girona, J, Guardiola, M, Ozcariz, E, Amigó, N, Rosales, R, Esteban, Y, Banús, H, Alsina, GG, González-Lleó, A, Rojo-Martínez, G, Ribalta, J. 01/08/2025. Atherosclerosis. 407

    Initiating Empagliflozin and Sacubitril/Valsartan Early After Acute Myocardial Infarction: Mechanistic Study.

    Martínez-Falguera D, Aranyó J, Ferrer-Curriu G, Teis A, Revuelta-Lopez E, Diaz-Güemes I, Monguió-Tortajada M, Fadeuilhe E, Rodríguez-Leor O, Poblador F, Montejo B, Roura S, Villuendas R, Sarrias A, Bazan V, Jorge E, Delgado V, Jimenez-Trinidad FR, Rigol M, Martinez-Micaelo N, Amigó N, Bayes-Genis A, Bisbal F, Gálvez-Montón C. 03/06/2025. Journal of the American Heart Association. 14. PMID: 40417813. doi: 10.1161/JAHA.124.040214

    Homozygous Familial Hypercholesterolemia Is a Life-Limiting Condition Medical Life-Trajectories in the Post-2010 Era

    Mulder, JWCM, Reijman, MD, Kusters, DM, Boersma, E, Alnouri, F, Blom, DJ, Catapano, AL, Cuchel, M, Dann, EJ, Freiberger, T, Groselj, U, Harada-Shiba, M, Hovingh, GK, Iatan, I, Ibarretxe, D, Kayikcioglu, M, Kim, NT, Klingel, R, Raal, FJ, Reeskamp, LF, Sadiq, F, Schonck, WAM, Tromp, TR, Truong, TH, Wiegman, A, van Lennep, JER. 20/05/2025. Journal Of The American College Of Cardiology. 85. PMID: 40368578. doi: 10.1016/j.jacc.2025.04.005

    miR-130a expression is related to aortic dilation in bicuspid aortic valve children

    Antequera-González, B, Collell-Hernández, R, Martínez-Micaelo, N, Marimon-Blanch, C, Carbonell-Prat, B, Escribano, J, Alegret, JM. 26/01/2024. Pediatric Research. 95. PMID: 38273119. doi: 10.1038/s41390-024-03018-5

    The Lipoprotein Profile Evaluated by 1H-NMR Improves the Performance of Genetic Testing in Familial Hypercholesterolemia

    Daiana, I, Didac, L, Celia, RB, Natalia, A, Nuria, P, Roberto, S, Ana, GL, Nuria, A, Josefa, G, Lluis, M. 23/01/2024. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 109. PMID: 38262691. doi: 10.1210/clinem/dgae037

    Quantification of lipoproteins by proton nuclear magnetic resonance spectroscopy (1H-NMRS) improves the prediction of cardiac autonomic dysfunction in patients with type 1 diabetes

    Nattero-Chávez, L, Insenser, M, Amigó, N, Samino, S, Martínez-Micaelo, N, Avendaño, BD, Tobar, AQ, Escobar-Morreale, HF, Luque-Ramírez, M. 06/01/2024. Journal Of Endocrinological Investigation. 47. PMID: 38182920. doi: 10.1007/s40618-023-02289-9

    Patients who suffer a first atherosclerotic cardiovascular event while taking statins are often far off of lipid targets.

    Masana L, Díaz Moya G, Pérez de Isla L. 01/01/2024. Nutrition Metabolism And Cardiovascular Diseases. 34. PMID: 38092606. doi: 10.1016/j.numecd.2023.09.022

    Specific Multiomic Profiling in Aortic Stenosis in Bicuspid Aortic Valve Disease.

    Antequera-González B, Martínez-Micaelo N, Sureda-Barbosa C, Galian-Gay L, Siliato-Robles MS, Ligero C, Evangelista A, Alegret JM. 06/02/2024. Biomedicines. 12. PMID: 38397982. doi: 10.3390/biomedicines12020380

    Impact of PCSK9 inhibitors in glycaemic control and new-onset diabetes

    González-Lleó, AM, Sánchez-Hernández, RM, Plana, N, Ibarretxe, D, Rehues, P, Ribalta, J, Llop, D, Wägner, AM, Masana, L, Boronat, M. 03/01/2024. Cardiovascular Diabetology. 23. PMID: 38172901. doi: 10.1186/s12933-023-02077-y

    PPARß/d upregulates the insulin receptor ß subunit in skeletal muscle by reducing lysosomal activity and EphB4 levels

    Wang, JR, Jurado-Aguilar, J, Barroso, E, Rodriguez-Calvo, R, Camins, A, Wahli, W, Palomer, X, Vázquez-Carrera, M. 18/12/2024. Cell Communication And Signaling. 22. PMID: 39696437. doi: 10.1186/s12964-024-01972-5

    Homozygous Familial Hypercholesterolemia in Spain: Data From Registry of the Spanish Atherosclerosis Society

    Sánchez-Hernández, RM, Ibarretxe, D, Jiménez, FF, Martínez-Hervás, S, Blanco-Echevarria, A, Rodríguez, BC, Rodríguez-Carnero, G, Ordiales, MMM, Pérez, A, González-Bustos, P, Armesto, RA, Sánchez-Sobrino, P, Masana, L, Civeira, F. 05/12/2024. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 110. PMID: 39514762. doi: 10.1210/clinem/dgae784

    ApoC-III proteoforms are associated with better lipid, inflammatory, and glucose profiles independent of total apoC-III

    Rehues, P, Girona, J, Guardiola, M, Ozcariz, E, Amigó, N, Rosales, R, Esteban, Y, Banús, H, Gavaldà-Alsina, G, González-Lleó, A, Rojo-Martínez, G, Ribalta, J. 04/12/2024. Cardiovascular Diabetology. 23. PMID: 39633383. doi: 10.1186/s12933-024-02531-5

    Angiopoietin-2, vascular endothelial growth factor family, and heparin binding endothelial growth factor are associated with subclinical atherosclerosis in rheumatoid arthritis

    Pàmies, A, Llop, D, Ibarretxe, D, Rosales, R, Masana, L, Vallvé, JC, Paredes, S. 01/12/2024. Computational and structural biotechnology journal. 23. PMID: 38689721. doi: 10.1016/j.csbj.2024.04.042

    Inclisiran, Reasons for a Novel Agent in a Crowded Therapeutic Field

    Di Giacomo-Barbagallo, F, Andreychuk, N, Scicali, R, Gonzalez-Lleo, A, Piro, S, Masana, L, Ibarretxe, D. 01/12/2024. Current Atherosclerosis Reports. 27. PMID: 39786678. doi: 10.1007/s11883-024-01271-x

    New drugs for treating dyslipidemias. From small molecules to small interfering RNAs

    Masana, L, Ibarretxe, D. 01/12/2024. CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS. 36. PMID: 39645293. doi: 10.1016/j.arteri.2024.07.004

    Lomitapide for the treatment of paediatric patients with homozygous familial hypercholesterolaemia (APH-19) results from the efficacy phase of an open-label, multicentre, phase 3 study

    Masana, L, Zambon, A, Schmitt, CP, Taylan, C, Driemeyer, J, Cohen, H, Buonuomo, PS, Alashwal, A, Al-Dubayee, M, Kholaif, N, Diaz-Diaz, JL, Maatouk, F, Martinez-Hervas, S, Mangal, B, Löwe, S, Cunningham, T. 01/12/2024. Lancet Diabetes & Endocrinology. 12. PMID: 39426393. doi: 10.1016/S2213-8587(24)00233-X

    Identification of patient-reported outcomes measures (PROMs) and patient-reported experiences measures (PREMs) in Gaucher disease in Spain

    Giraldo, P, Camprodón, M, Alcolea, PC, Gras-Colomer, E, Ibarretxe, D, Lakhwani, S, Mora, E, Calderón, MPV, Morales-Conejo, M. 15/11/2024. Medicina Clinica. 163. PMID: 39095265. doi: 10.1016/j.medcli.2024.06.006

    H-NMR metabolomics identifies three distinct metabolic profiles differentially associated with cardiometabolic risk in patients with obesity in the Di@bet.es cohort

    Ozcariz, E, Guardiola, M, Amigó, N, Valdés, S, Oualla-Bachiri, W, Rehues, P, Rojo-Martinez, G, Ribalta, J. 07/11/2024. Cardiovascular Diabetology. 23. PMID: 39511627. doi: 10.1186/s12933-024-02488-5

    Comprehensive analysis of glycoprotein profiles and their association with cardiovascular disease-related microRNAs in rheumatoid arthritis, metabolic disorders, and controls

    Llop, D, Paredes, S, Rosales, R, Amigo, N, Masana, L, Ribalta, J, Vallvé, JC. 02/11/2024. Scientific Reports. 14. PMID: 39488576. doi: 10.1038/s41598-024-77772-1

    The GDF15 3' UTR Polymorphism rs1054564 Is Associated with Diabetes and Subclinical Atherosclerosis

    Guardiola, M, Girona, J, Barroso, E, García-Altares, M, Ibarretxe, D, Plana, N, Ribalta, J, Correig, X, Vázquez-Carrera, M, Masana, L, Rodríguez-Calvo, R. 01/11/2024. International Journal Of Molecular Sciences. 25. PMID: 39596055. doi: 10.3390/ijms252211985

    Serum Levels of Trace Elements (Magnesium, Iron, Zinc, Selenium, and Strontium) are Differentially Associated with Surrogate Markers of Cardiovascular Disease Risk in Patients with Rheumatoid Arthritis

    Vera, E, Vallvé, JC, Linares, V, Paredes, S, Ibarretxe, D, Bellés, M. 30/10/2024. Biological Trace Element Research. 203. PMID: 39477851. doi: 10.1007/s12011-024-04434-8

    Effectiveness of the CNIC polypill in secondary cardiovascular prevention in the subgroup of patients of the NEPTUNO study using atorvastatin doses of 20 mg

    González-Juanatey, JR, Cordero, A, Masana, L, Dalmau, R. 01/10/2024. Archivos de cardiologia de Mexico. 94. PMID: 38843861. doi: 10.24875/ACM.23000230

    PCSK9 Antibodies Treatment Specifically Enhances the Macrophage-specific Reverse Cholesterol Transport Pathway in Heterozygous Familial Hypercholesterolemia.

    Borràs C, Canyelles M, Girona J, Ibarretxe D, Santos D, Revilla G, Llorente-Cortes V, Rotllan N, Kovanen PT, Jauhiainen M, Lee-Rueckert M, Masana L, Arrieta F, Martínez-Botas J, Gómez-Coronado D, Ribalta J, Tondo M, Blanco-Vaca F, Escolà-Gil JC. 01/10/2024. JACC-Basic to Translational Science. 9. PMID: 39534644. doi: 10.1016/j.jacbts.2024.06.008

    Differential analysis of lipoprotein and glycoprotein profiles in bacterial infections and COVID-19 using proton nuclear magnetic resonance and machine learning

    Iftimie, S, Amigó, N, Martínez-Micaelo, N, López-Azcona, AF, Martínez-Navidad, C, Castañé, H, Jiménez-Franco, A, Ribalta, J, Parra, S, Castro, A, Camps, J, Joven, J. 15/09/2024. Heliyon. 10. PMID: 39286163. doi: 10.1016/j.heliyon.2024.e37115

    PCSK9 inhibitors on the management of primary and secondary cardiovascular prevention

    Marco-Benedí, V, Sánchez-Hernández, RM, Díaz, JL, Jarauta, E, Suárez-Tembra, M, Pintó, X, Morillas, C, Plana, N, Pedro-Botet, J, Civeira, F. 10/09/2024. Lipids In Health And Disease. 23. PMID: 39256734. doi: 10.1186/s12944-024-02283-x

    Enhanced Association of Novel Cardiovascular Biomarkers Fetuin-A and Catestatin with Serological and Inflammatory Markers in Rheumatoid Arthritis Patients

    Pamies, A, Llop, D, Ibarretxe, D, Rosales, R, Girona, J, Masana, L, Vallvé, JC, Paredes, S. 01/09/2024. International Journal Of Molecular Sciences. 25. PMID: 39337398. doi: 10.3390/ijms25189910

    Lipidomic and metabolomic changes in community-acquired and COVID-19 pneumonia

    Saballs, M, Parra, S, Martínez, N, Amigo, N, Cabau, L, Iftimie, S, Pavon, R, Gabaldó, X, Correig, X, Paredes, S, Vallvé, JM, Castro, A. 01/09/2024. Journal Of Lipid Research. 65. PMID: 39154734. doi: 10.1016/j.jlr.2024.100622

    Increasing the complexity of lipoprotein characterization for cardiovascular risk in type 2 diabetes

    Guardiola, M, Rehues, P, Amigó, N, Arrieta, F, Botana, M, Gimeno-Orna, JA, Girona, J, Martínez-Montoro, JI, Ortega, E, Pérez-Pérez, A, Sánchez-Margalet, V, Pedro-Botet, J, Ribalta, J. 01/08/2024. European Journal Of Clinical Investigation. 54. PMID: 38613414. doi: 10.1111/eci.14214

    HOFH IS A LIFE LIMITING CONDITION: THE LIFE JOURNEY OF DECEASED HOFH PATIENTS IN THE HICC REGISTRY

    Mulder, JWCM, Reijman, MD, Kusters, DM, Boersma, E, Blom, D, Cuchel, M, Dann, EJ, Freiberger, T, Groselj, U, Harada-Shiba, M, Hovingh, G, Ibarretxe, D, Kim, T, Klingel, R, Raal, FJ, Reeskamp, L, Sadiq, F, Schonck, W, Truong, H, Tromp, TR, Wiegman, A, Van Lennep, JR. 01/08/2024. Atherosclerosis. 395

    HIGHER ADHERENCE TO THE MEDITERRANEAN DIET IS ASSOCIATED WITH IMPROVED GLYCEMIC CONTROL AND REDUCED ATHEROGENIC PATTERNS: A POPULATION-BASED STUDY

    Olmastroni, E, Amigo, N, Ribalta, J, Guardiola, M, Rojo, G, Casula, M, Magni, P, Catapano, A. 01/08/2024. Atherosclerosis. 395

    Consensus on lipoprotein(a) of the Spanish Society of Arteriosclerosis. Literature review and recommendations for clinical practice

    Delgado-Lista, J, Mostaza, JM, Arrobas-Velilla, T, Blanco-Vaca, F, Masana, L, Pedro-Botet, J, Perez-Martinez, P, Civeira, F, Cuende-Melero, JI, Gomez-Barrado, JJ, Lahoz, C, Pinto, X, Suarez-Tembra, M, Lopez-Miranda, J, Guijarro, C. 01/07/2024. CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS. 36. PMID: 38599943. doi: 10.1016/j.arteri.2024.03.002

    Clinical practice recommendations on lipoprotein apheresis for children with homozygous familial hypercholesterolaemia: An expert consensus statement from ERKNet and ESPN

    Reijman, MD, Kusters, DM, Groothoff, JW, Arbeiter, K, Dann, EJ, de Boer, LM, de Ferranti, SD, Gallo, A, Greber-Platzer, S, Hartz, J, Hudgins, LC, Ibarretxe, D, Kayikcioglu, M, Klingel, R, Kolovou, GD, Oh, J, Planken, RN, Stefanutti, C, Taylan, C, Wiegman, A, Schmitt, CP. 01/05/2024. Atherosclerosis. 392. PMID: 38598969. doi: 10.1016/j.atherosclerosis.2024.117525

    SEA 2024 Standards for Global Control of Vascular Risk

    Mostaza, JM, Pintó, X, Armario, P, Masana, L, Real, JT, Valdivielso, P, Arrobas-Velilla, T, Baeza-Trinidad, R, Calmarza, P, Cebollada, J, Civera-Andrés, M, Melero, JIC, Díaz-Díaz, JL, Espíldora-Hernández, J, Pardo, JF, Guijarro, C, Jericó, C, Laclaustra, M, Lahoz, C, López-Miranda, J, Martínez-Hervás, S, Muñiz-Grijalvo, O, Páramo, JA, Pascual, V, Pedro-Boteta, J, Pérez-Martínez, P, Puzo, J. 01/05/2024. CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS. 36. PMID: 38490888. doi: 10.1016/j.arteri.2024.02.001

    Lipidomics Reveals Myocardial Lipid Composition in a Murine Model of Insulin Resistance Induced by a High-Fat Diet

    Girona, J, Soler, O, Samino, S, Junza, A, Martínez-Micaelo, N, García-Altares, M, Ràfols, P, Esteban, Y, Yanes, O, Correig, X, Masana, L, Rodríguez-Calvo, R. 01/03/2024. International Journal Of Molecular Sciences. 25. PMID: 38473949. doi: 10.3390/ijms25052702

    The CNIC-polypill (acetylsalicylic acid, atorvastatin, and ramipril), an effective and cost-saving secondary prevention strategy compared with other therapeutic options in patients with ischaemic heart disease

    Dalmau, R, Cordero, A, Masana, L, Ruiz, E, Sicras-Mainar, A, González-Juanatey, JR. 01/03/2024. European Heart Journal Open. 4. PMID: 38686352. doi: 10.1093/ehjopen/oeae027

    Correction to: Real-World Outcomes with Lomitapide Use in Paediatric Patients with Homozygous Familial Hypercholesterolaemia.

    Ben-Omran T, Masana L, Kolovou G, Ariceta G, Nóvoa FJ, Lund AM, Bogsrud MP, Araujo M, Hussein O, Ibarretxe D, Sanchez-Hernández RM, Santos RD. 20/02/2024. Advances In Therapy. 41. PMID: 38376744. doi: 10.1007/s12325-023-02739-z

    Role of Leptin in Obesity, Cardiovascular Disease, and Type 2 Diabetes.

    Vilariño-García T, Polonio-González ML, Pérez-Pérez A, Ribalta J, Arrieta F, Aguilar M, Obaya JC, Gimeno-Orna JA, Iglesias P, Navarro J, Durán S, Pedro-Botet J, Sánchez-Margalet V. 16/02/2024. International Journal Of Molecular Sciences. 25. PMID: 38397015. doi: 10.3390/ijms25042338

    Association between exposure to air pollution and blood lipids in the general population of Spain

    Valdés, S, Doulatram-Gamgaram, V, Maldonado-Araque, C, Garcia-Escobar, E, Garcia-Serrano, S, Oualla-Bachiri, W, Garcia-Vivanco, M, Garrido, JL, Gil, V, Martin-Llorente, F, Calle-Pascual, A, Castaño, L, Delgado, E, Menéndez, E, Franch-Nadal, J, Gaztambide, S, Girbés, J, Chaves, FJ, Galán-García, JL, Aguilera-Venegas, G, Vallvé, JC, Amigó, N, Guardiola, M, Ribalta, J, Rojo-Martínez, G. 01/02/2024. European Journal Of Clinical Investigation. 54. PMID: 37795744. doi: 10.1111/eci.14101

    A panel of plasma microRNAs improves the assessment of surrogate markers of cardiovascular disease in rheumatoid arthritis patients

    Llop, D, Ibarretxe, D, Plana, N, Rosales, R, Taverner, D, Masana, L, Vallvé, JC, Paredes, S. 03/04/2023. Rheumatology. 62. PMID: 36048908. doi: 10.1093/rheumatology/keac483

    MicroRNAs as potential diagnostic biomarkers.

    Llop D. 24/02/2023. Medicina Clinica. 160. PMID: 36241577. doi: 10.1016/j.medcli.2022.08.013

    Pregnancy homocysteine and cobalamin status predict childhood metabolic health in the offspring

    Rojas-Gómez, A, Solé-Navais, P, Cavallé-Busquets, P, Ornosa-Martin, G, Grifoll, C, Ramos-Rodriguez, C, Fernandez-Ballart, J, Masana, L, Ballesteros, M, Ueland, PM, Murphy, MM. 01/02/2023. Pediatric Research. 93. PMID: 35641553. doi: 10.1038/s41390-022-02117-5

    Glycoprotein Serum Concentrations Assessed By 1H-NMR are Increased in Patients With High Blood Pressure.

    Andreychuk N, Llop D, Moreno-Vedia J, Girona J, Ibarretxe D, Rodríguez-Borjabad C, Plana N, Masana L. 01/02/2023. Hypertension. 80. PMID: 36384288. doi: 10.1161/HYPERTENSIONAHA.122.20137

    Real life data: follow-up assessment on Spanish Gaucher disease patients treated with eliglustat. TRAZELGA project.

    Serrano-Gonzalo I, de Frutos LL, Lahoz-Gil C, Delgado-Mateos F, Fernández-Galán MÁ, Morales-Conejo M, Calle-Gordo MV, Ibarretxe-Gerediaga D, Madinaveitia-Ochoa A, Albarracin-Arraigosa A, Balanzat-Muñoz J, Correcher-Medina P, García-Frade LJ, Hernández-Rivas JM, Labbadia F, López-Dupla JM, Lozano-Almela ML, Mora-Casterá E, Noya-Pereira MS, Ruíz-Guinaldo MÁ, Del Mar Tormo-Díaz M, Vitoria-Miñana I, Arévalo-Vargas I, Andrade-Campos M, Giraldo P. 15/12/2023. Orphanet Journal Of Rare Diseases. 18. PMID: 38102667. doi: 10.1186/s13023-023-02939-4

    Lipidomics of triglyceride-rich lipoproteins derived from hyperlipidemic patients on inflammation.

    Moreno-Vedia J, Llop D, Rodríguez-Calvo R, Plana N, Amigó N, Rosales R, Esteban Y, Masana L, Ibarretxe D, Girona J. 27/11/2023. European Journal Of Clinical Investigation. 54. PMID: 38010694. doi: 10.1111/eci.14132

    Long-term treatment persistence and maintained reduction of LDL-cholesterol levels with evolocumab over 30 months: Results from the Spanish cohort of the European prospective HEYMANS study.

    Blanco Echevarría A, García Díaz JD, Caixas A, Plana Gil N, Rico Corral MÁ, Bridges I, Dhalwani N, Gatell Menchen S, Ray KK. 01/11/2023. CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS. 35. PMID: 37236829. doi: 10.1016/j.arteri.2023.04.004

    Plasma Expression of Carotid Plaque Presence-Related MicroRNAs Is Associated with Inflammation in Patients with Rheumatoid Arthritis

    Llop, D, Paredes, S, Ibarretxe, D, Taverner, D, Plana, N, Rosales, R, Masana, L, Vallvé, JC. 01/10/2023. International Journal Of Molecular Sciences. 24. PMID: 37895027. doi: 10.3390/ijms242015347

    Lipoprotein profile assessed by 1H NMR, BMI and blood pressure are associated with vascular alterations in children with familial hypercholesterolaemia

    Llop, D, Feliu, A, Ibarretxe, D, Escribano, J, Plana, N, Borjabad-Rodríguez, C, Masana, L, Vallvé, JC. 01/10/2023. Nutrition Metabolism And Cardiovascular Diseases. 33. PMID: 37543518. doi: 10.1016/j.numecd.2023.06.012

    Serum branch-chained amino acids are increased in type 2 diabetes and associated with atherosclerotic cardiovascular disease

    Moreno-Vedia, J, Llop, D, Rodríguez-Calvo, R, Plana, N, Amigó, N, Rosales, R, Esteban, Y, Girona, J, Masana, L, Ibarretxe, D. 14/09/2023. Cardiovascular Diabetology. 22. PMID: 37710233. doi: 10.1186/s12933-023-01958-6

    Associations between blood levels of trace elements and cardiovascular risk factors in patients with rheumatoid arthritis

    Vera, E, Vallvé, JC, Linares, V, Mateu, MB. 01/09/2023. Toxicology Letters. 384

    NMR-based metabolomic profiling identifies inflammation and muscle-related metabolites as predictors of incident type 2 diabetes mellitus beyond glucose: The Di@bet.es study

    Ozcariz, E, Guardiola, M, Amigó, N, Rojo-Martínez, G, Valdés, S, Rehues, P, Masana, L, Ribalta, J. 01/08/2023. Diabetes Research And Clinical Practice. 202. PMID: 37301326. doi: 10.1016/j.diabres.2023.110772

    Lipidomics of triglyceride-rich lipoproteins determines Particle/THP-1 macrophages Interaction and systemic inflammatory profile assessed by 1H-NMR

    Vedia, JM, Rosales, R, Esteban, Y, Rodriguez-Calvo, R, Plana, N, Ibarretxe, D, Girona, J, Masana, L. 01/08/2023. Atherosclerosis. 379

    Gradual Increase in Inflammation-Linked Glycoproteins and a Proatherogenic Lipoprotein Profile in the Early Stages of Psychosis as Characterized by (1)H NMR Blood Analysis.

    Gallart-Palau X, Muntané G, Martorell L, Amigó N, Correig X, Ribalta J, Sánchez-Gistau V, Labad J, Vilella E. 07/07/2023. Journal Of Proteome Research. 22. PMID: 37354121. doi: 10.1021/acs.jproteome.2c00847

    2023 Update on European Atherosclerosis Society Consensus Statement on Homozygous Familial Hypercholesterolaemia: new treatments and clinical guidance.

    Cuchel M, Raal FJ, Hegele RA, Al-Rasadi K, Arca M, Averna M, Bruckert E, Freiberger T, Gaudet D, Harada-Shiba M, Hudgins LC, Kayikcioglu M, Masana L, Parhofer KG, Roeters van Lennep JE, Santos RD, Stroes ESG, Watts GF, Wiegman A, Stock JK, Tokgözoglu LS, Catapano AL, Ray KK. 01/07/2023. European Heart Journal. 44. PMID: 37130090. doi: 10.1093/eurheartj/ehad197

    Association between Nordic and Mediterranean diets with lipoprotein phenotype assessed by (1)HNMR in children with familial hypercholesterolemia.

    Rodríguez-Borjabad C, Narveud I, Christensen JJ, Ibarretxe D, Andreychuk N, Girona J, Torvik K, Folkedal G, Bogsrud MP, Retterstøl K, Plana N, Masana L, Holven KB. 01/05/2023. Atherosclerosis. 373. PMID: 37137225. doi: 10.1016/j.atherosclerosis.2023.04.009

    Metabolic Overlap between Alzheimer's Disease and Metabolic Syndrome Identifies the PVRL2 Gene as a New Modulator of Diabetic Dyslipidemia

    Guardiola, M, Muntané, G, Martínez, I, Martorell, L, Girona, J, Ibarretxe, D, Plana, N, Bullido, MJ, Vilella, E, Ribalta, J. 18/04/2023. International Journal Of Molecular Sciences. 24. PMID: 37108578. doi: 10.3390/ijms24087415

    Lipid lowering combination therapy: From prevention to atherosclerosis plaque treatment

    Masana, L, Plana, N, Andreychuk, N, Ibarretxe, D. 01/04/2023. Pharmacological Research. 190. PMID: 36940892. doi: 10.1016/j.phrs.2023.106738

    Efficacy and safety of leflunomide in the management of large vessel vasculitis: A systematic review and metaanalysis of cohort studies

    Narváez, J, Estrada, P, Llop, D, Vidal-Montal, P, Brugarolas, E, Maymó-Paituvi, P, Palacios-Olid, J, Nolla, JM. 01/04/2023. Seminars In Arthritis And Rheumatism. 59. PMID: 36645992. doi: 10.1016/j.semarthrit.2023.152166

    Fatty Acid Binding Proteins 3 and 4 Predict Both All-Cause and Cardiovascular Mortality in Subjects with Chronic Heart Failure and Type 2 Diabetes Mellitus

    Rodríguez-Calvo, R, Granado-Casas, M, de Oca, APM, Julian, MT, Domingo, M, Codina, P, Santiago-Vacas, E, Cediel, G, Julve, J, Rossell, J, Masana, L, Mauricio, D, Lupón, J, Bayes-Genis, A, Alonso, N. 01/03/2023. Antioxidants. 12. PMID: 36978893. doi: 10.3390/antiox12030645

    PCSK9 Inhibitors Have Apolipoprotein C-III-Related Anti-Inflammatory Activity, Assessed by 1H-NMR Glycoprotein Profile in Subjects at High or very High Cardiovascular Risk

    Rehues, P, Girona, J, Guardiola, M, Plana, N, Scicali, R, Piro, S, Muñiz-Grijalvo, O, Díaz-Díaz, JL, Recasens, L, Pinyol, M, Rosales, R, Esteban, Y, Amigó, N, Masana, L, Ibarretxe, D, Ribalta, J. 01/02/2023. International Journal Of Molecular Sciences. 24. PMID: 36768645. doi: 10.3390/ijms24032319

    Diagnosis of Familial Dysbetalipoproteinemia Based on the Lipid Abnormalities Driven by APOE2/E2 Genotype

    Bea, AM, Cenarro, A, Marco-Benedi, V, Laclaustra, M, Martin, C, Ibarretxe, D, Pinto, X, Arrobas, T, Vinals, C, Civeira, F, Olmos, S. 01/02/2023. Clinical Chemistry. 69. PMID: 36644927. doi: 10.1093/clinchem/hvac213

    Women with familial hypercholesterolemia phenotype are undertreated and poorly controlled compared to men

    Zamora, A, Ramos, R, Comas-Cufi, M, García-Gil, M, Martí-Lluch, R, Plana, N, Alves-Cabratosa, L, Ponjoan, A, Rodríguez-Borjabad, C, Ibarretxe, D, Roman-Degano, I, Marrugat, J, Elosua, R, Martín-Urda, A, Masana, L. 27/01/2023. Scientific Reports. 13. PMID: 36707646. doi: 10.1038/s41598-023-27963-z

    DDR1 and Its Ligand, Collagen IV, Are Involved in In Vitro Oligodendrocyte Maturation

    Silva, ME, Hernández-Andrade, M, Abasolo, N, Espinoza-Cruells, C, Mansilla, JB, Reyes, CR, Aranda, S, Esteban, Y, Rodriguez-Calvo, R, Martorell, L, Muntane, G, Rivera, FJ, Vilella, E. 01/01/2023. International Journal Of Molecular Sciences. 24. PMID: 36675255. doi: 10.3390/ijms24021742

    Economic Burden Associated with the Treatment with a Cardiovascular Polypill in Secondary Prevention in Spain: Cost-Effectiveness Results of the NEPTUNO Study

    Cordero, A, González-Gallarza, RD, Masana, L, Fuster, V, Castellano, JM, Olivar, JER, Zsolt, I, Sicras-Mainar, A, Juanatey, JRG. 01/01/2023. Clinicoeconomics And Outcomes Research. 15. PMID: 37489131. doi: 10.2147/CEOR.S396290

    Lomitapide for the treatment of paediatric homozygous familial hypercholesterolaemia patients - Results from the efficacy phase of the APH-19 study

    Masana, L, Zambon, A, Schmitt, CP, Taylan, C, Driemeyer, J, Cohen, H, Buonuomo, PS, Alashwal, A, Al-Dubayee, M, Diaz-Diaz, JL, Maatouk, F, Hervás, SM, Mangal, B, Löwe, S, Cunningham, T. 01/12/2023. Atherosclerosis Plus. 54. doi: 10.1016/j.athplu.2023.07.008

    The lockdown of the locked-in: experiences of persons with Locked-in Syndrome during COVID-19 pandemic

    Masana, L, Vidal, F. 03/11/2023. DISABILITY & SOCIETY. 40. doi: 10.1080/09687599.2023.2279484

    Triglyceride content increases while cholesterol content decreases in HDL and LDL plus IDL fractions following normal meals: The Copenhagen General Population Study of 25,656 individuals

    Johansen, MO, Moreno-Vedia, J, Balling, M, Smith, GD, Nordestgaard, BG. 01/10/2023. Atherosclerosis. 383. PMID: 37820443. doi: 10.1016/j.atherosclerosis.2023.117316

    PCSK9 INHIBITORS HAVE ANTI-INFLAMMATORY ACTIVITY ASSESSED BY 1H-NMR GLYCOPROTEIN PROFILE IN SUBJECTS AT HIGH OR VERY HIGH CARDIOVASCULAR RISK

    Rehues, P, Girona, J, Guardiola, M, Plana, N, Scicali, R, Piro, S, Muñíz-Grijalvo, O, Díaz-Díaz, JL, Recasens, L, Pinyol, M, Rosales, R, Esteban, Y, Amigó, N, Masana, L, Ibarretxe, D, Ribalta, J. 01/08/2023. Atherosclerosis. 379

    AGE EXACERBATES TRIGLYCERIDE-INDUCED HDLC-LOWERING IN WOMEN

    Guardiola, M, Vallvé, J, Rehues, P, Rojo, G, Ribalta, J. 01/08/2023. Atherosclerosis. 379

    Phosphorylation and shedding of DDR1 in the HOG16 human oligodendroglial cell line upon collagen IV incubation

    Castel, SA, Esteban, Y, Rodríquez-Calvo, R, Vilella, E. 01/07/2023. Glia. 71

    Impact of physician's perception about LDL cholesterol control in clinical practice when treating patients in Spain

    Cosín-Sales, J, Ruiz, RC, Díaz, JLD, Cervantes, CE, Olmo, MRF, Gómez-Doblas, JJ, Mostaza, JM, Pedro-Botet, J, Gili, NP, Valdivielso, P. 01/06/2023. Atherosclerosis. 375. PMID: 37245425. doi: 10.1016/j.atherosclerosis.2023.04.013

    Glycoprotein and Lipoprotein Profiles Assessed by 1H-NMR and Its Relation to Ascending Aortic Dilatation in Bicuspid Aortic Valve Disease.

    Antequera-González B, Faiges M, Martínez-Micaelo N, Galian-Gay L, Ligero C, Ferré-Vallverdú M, Masana L, Amigó N, Evangelista A, Alegret JM. 31/12/2022. Journal of clinical medicine. 12. PMID: 36615132. doi: 10.3390/jcm12010332

    1H-magnetic resonance spectroscopy lipoprotein profile in patients with chronic heart failure versus matched controls

    Teis, A, Castelblanco, E, Cediel, G, Amigó, N, Julve, J, Ribalta, J, Guardiola, M, Franch, J, Bermúdez-López, M, Codina, P, Lupón, J, Mauricio, D, Alonso, N, Bayés-Genís, A. 01/11/2022. REVISTA ESPANOLA DE CARDIOLOGIA. 75. PMID: 34716123. doi: 10.1016/j.rec.2021.09.008

    The CNIC-Polypill reduces recurrent major cardiovascular events in real-life secondary prevention patients in Spain: The NEPTUNO study

    Gonzalez-Juanatey, JR, Cordero, A, Castellano, JM, Masana, L, Dalmau, R, Ruiz, E, Sicras-Mainar, A, Fuster, V. 15/08/2022. International Journal Of Cardiology. 361. PMID: 35569611. doi: 10.1016/j.ijcard.2022.05.015

    HUMAN PLASMA GLYCOPROTEIN PROFILE MEASURED BY 1H-NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY IN PATIENTS WITH DIABETES AND/OR ATHEROGENIC DYSLIPIDEMIA, A NEW METHOD TO ASSESS INFLAMMATION

    Amigo, N, Fuertes, R, Malo, A, Plana, N, Ibarretxe, D, Girona, J, Correig, X, Masana, L. 01/08/2022. Atherosclerosis. 355

    CHARACTERIZATION OF THE LPS AND 3OHFA CONTENTS IN THE LIPOPROTEIN FRACTIONS AND LIPOPROTEIN PARTICLES OF HEALTHY SUBJECTS

    Rehues, P, Rodríguez, M, Guardiola, M, Ribalta, J. 01/08/2022. Atherosclerosis. 355

    EFFECTS OF INHIBITOR K-CARRAGEENAN ON HAECS INFLAMMATORY RESPONSE TO LDLS ISOLATED FROM SLE PATIENTS

    Parra, S, Avila, A, Rivalta, J, Guardiola, M, Rodriguez, R, Castro, A. 01/06/2022. Annals Of The Rheumatic Diseases. 81. doi: 10.1136/annrheumdis-2022-eular.4950

    FATIGUE IN RHEUMATOID ARTHRITIS: DOES PATIENT AGE INFLUENCE?

    Rodriguez-Muguruza, S, Castro, S, Poveda, MJ, Paredes, S, Taverner, D, Fontova, R. 01/06/2022. Annals Of The Rheumatic Diseases. 81. doi: 10.1136/annrheumdis-2022-eular.1138

    Muscular carnosine is a marker for cardiorespiratory fitness and cardiometabolic risk factors in men with type 1 diabetes

    Brugnara, L, García, AI, Murillo, S, Ribalta, J, Fernandez, G, Marquez, S, Rodriguez, MA, Vinaixa, M, Amigó, N, Correig, X, Kalko, S, Pomes, J, Novials, A. 01/06/2022. European Journal Of Applied Physiology. 122. PMID: 35298695. doi: 10.1007/s00421-022-04929-z

    The Associations Between Sleep Disturbance, Psychological Dysfunction, Pain Intensity, and Pain Interference in Children with Chronic Pain

    Sole, E, Sharma, S, Ferreira-Valente, A, Pathak, A, Sanchez-Rodriguez, E, Jensen, MP, Miro, J. 30/05/2022. Pain Medicine. 23. PMID: 34850200. doi: 10.1093/pm/pnab333

    Implications of ACC/AHA Versus ESC/EAS LDL-C Recommendations for Residual Risk Reduction in ASCVD: A Simulation Study From DA VINCI

    Vallejo-Vaz, AJ, Bray, S, Villa, G, Brandts, J, Kiru, G, Murphy, J, Banach, M, De Servi, S, Gaita, D, Gouni-Berthold, I, Hovingh, GK, Jozwiak, JJ, Jukema, JW, Kiss, RG, Kownator, S, Iversen, HK, Maher, V, Masana, L, Parkhomenko, A, Peeters, A, Clifford, P, Raslova, K, Siostrzonek, P, Romeo, S, Tousoulis, D, Vlachopoulos, C, Vrablik, M, Catapano, AL, Poulter, NR, Ray, KK. 14/05/2022. Cardiovascular Drugs And Therapy. 37. PMID: 35567726. doi: 10.1007/s10557-022-07343-x

    NMR METABOLOMICS, A SUCCESSFUL STRATEGY TO IDENTIFY A TYPE 2 DIABETES MELLITUS (DM) MOLECULAR SIGNATURE BEYOND GLUCOSE IN THE DI@BETES STUDY

    Amigo, N, Ozcariz, E, Rojo, G, Guardiola, M, Ribalta, J. 25/04/2022. Diabetes Technology & Therapeutics. 24

    A Case Series Assessing the Effects of Lomitapide on Carotid Intima-Media Thickness in Adult Patients with Homozygous Familial Hypercholesterolaemia in a Real-World Setting

    Blom, DJ, Gaudet, D, Hegele, RA, Patel, DS, Cegla, J, Kolovou, G, Marin, LM. 01/04/2022. Advances In Therapy. 39. PMID: 35194765. doi: 10.1007/s12325-021-02031-y

    Combination lipid-lowering therapy as first-line strategy in very high-risk patients.

    Ray KK, Reeskamp LF, Laufs U, Banach M, Mach F, Tokgözoglu LS, Connolly DL, Gerrits AJ, Stroes ESG, Masana L, Kastelein JJP. 22/02/2022. European Heart Journal. 43. PMID: 34636884. doi: 10.1093/eurheartj/ehab718

    Effect of statin therapy on SARS-CoV-2 infection-related mortality in hospitalized patients

    Masana, L, Correig, E, Rodríguez-Borjabad, C, Anoro, E, Arroyo, JA, Jericó, C, Pedragosa, A, la Miret, M, Näf, S, Pardo, A, Perea, V, Pérez-Bernalte, R, Plana, N, Ramírez-Montesinos, R, Royuela, M, Soler, C, Urquizu-Padilla, M, Zamora, A, Pedro-Botet, J. 16/02/2022. European Heart Journal-Cardiovascular Pharmacotherapy. 8. PMID: 33135047. doi: 10.1093/ehjcvp/pvaa128

    Situation in 2020 of the requirements for the use of PCSK9 inhibitors in Spain: Results of a national survey

    Guijarro, C, Civeira, F, Lopez-Miranda, J, Masana, L, Pedro-Botet, J, Pinto, X, Valdivielso, P, Mostaza, JM. 01/02/2022. CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS. 34. PMID: 34656373. doi: 10.1016/j.arteri.2021.07.002

    Diabetes mellitus and cardiovascular risk: an update of the recommendations of the Diabetes and Cardiovascular Disease Working Group of the Spanish Society of Diabetes (SED, 2021)

    Arrieta, F, Pedro-Botet, J, Iglesias, P, Obaya, JC, Montanez, L, Maldonado, GF, Becerra, A, Navarro, J, Perez, JC, Petrecca, R, Pardo, JL, Ribalta, J, Sánchez-Margalet, V, Duran, S, Tébar, FJ, Aguilar, M. 01/02/2022. CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS. 34. PMID: 34330545. doi: 10.1016/j.arteri.2021.05.002

    DNA methylation pattern of hypertriglyceridemic subjects

    Guardiola, M, Ibarretxe, D, Plana, N, Masana, L, Ribalta, J. 01/02/2022. CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS. 34. PMID: 34879978. doi: 10.1016/j.arteri.2021.09.002

    Distribution of seven ApoC-III glycoforms in plasma, VLDL, IDL, LDL and HDL of healthy subjects

    Rodríguez, M, Rehues, P, Iranzo, V, Mora, J, Balsells, C, Guardiola, M, Ribalta, J. 16/01/2022. Journal Of Proteomics. 251. PMID: 34688878. doi: 10.1016/j.jprot.2021.104398

    Triglyceride-Rich Lipoproteins and Glycoprotein A and B Assessed by 1H-NMR in Metabolic-Associated Fatty Liver Disease

    Moreno-Vedia, J, Rosales, R, Ozcariz, E, Llop, D, Lahuerta, M, Benavent, M, Rodriguez-Calvo, R, Plana, N, Pedragosa, A, Masana, L, Castro, A, Ibarretxe, D, Girona, J. 10/01/2022. Frontiers in endocrinology. 12. PMID: 35082753. doi: 10.3389/fendo.2021.775677

    Magnetic resonance-assessed lipoprotein profile. The time has come for its clinical use

    Masana, L, Ibarretxe, D. 01/01/2022. REVISTA ESPANOLA DE CARDIOLOGIA. 75. PMID: 34607775. doi: 10.1016/j.recesp.2021.07.004

    Long-term exposure to PM(10) above WHO guidelines exacerbates COVID-19 severity and mortality.

    Marquès M, Correig E, Ibarretxe D, Anoro E, Antonio Arroyo J, Jericó C, Borrallo RM, Miret M, Perea V, Pérez-Bernalte R, Ramírez-Montesinos R, Royuela M, Soler C, Urquizu-Padilla M, Zamora A, Pedro-Botet J, Masana L. 01/01/2022. Environment International. 158. PMID: 34678637. doi: 10.1016/j.envint.2021.106930

    Unveiling the Role of the Fatty Acid Binding Protein 4 in the Metabolic-Associated Fatty Liver Disease

    Moreno-Vedia, J, Girona, J, Ibarretxe, D, Masana, L, Rodriguez-Calvo, R. 01/01/2022. Biomedicines. 10. PMID: 35052876. doi: 10.3390/biomedicines10010197

    Characterization of the LPS and 3OHFA Contents in the Lipoprotein Fractions and Lipoprotein Particles of Healthy Men

    Rehues, P, Rodríguez, M, Alvarez, J, Jiménez, M, Melià, A, Sempere, M, Balsells, C, Castillejo, G, Guardiola, M, Castro, A, Ribalta, J. 01/01/2022. Biomolecules. 12. PMID: 35053195. doi: 10.3390/biom12010047

    Cross-National Trends of Chronic Back Pain in Adolescents: Results From the HBSC Study, 2001-2014

    Roy, R, Galán, S, Sánchez-Rodríguez, E, Racine, M, Solé, E, Jensen, MP, Miró, J. 01/01/2022. Journal Of Pain. 23. PMID: 34339858. doi: 10.1016/j.jpain.2021.07.002

    Nuclear magnetic resonance spectroscopy measure of protein glycosylation is a biomarker of activity and metabolic complications in Inflammatory Bowel Disease

    Mateo, SG, Martínez-Dominguez, SJ, Gonzalvo, MCA, Refaie, E, Llera, BG, Cabrejas, EA, Sanz, B, Grau, NA, Ribalta, J, Martínez-Micaelo, N, Gargallo-Puyuelo, CJ, Gomollón, F. 01/01/2022. Journal Of Crohns & Colitis. 16

    Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol

    Wu, PT, Moon, JY, Daghlas, I, Franco, G, Porneala, BC, Ahmadizar, F, Richardson, TG, Isaksen, JL, Hindy, G, Yao, J, Sitlani, CM, Raffield, LM, Yanek, LR, Feitosa, MF, Cuadrat, RRC, Qi, QB, Ikram, MA, Ellervik, C, Ericson, U, Goodarzi, MO, Brody, JA, Lange, L, Mercader, JM, Vaidya, D, An, P, Schulze, MB, Masana, L, Ghanbari, M, Olesen, MS, Cai, JW, Guo, XQ, Floyd, JS, Jäger, S, Province, MA, Kalyani, RR, Psaty, BM, Orho-Melander, M, Ridker, PM, Kanters, JK, Uitterlinden, A, Smith, GD, Gill, D, Kaplan, RC, Kavousi, M, Raghavan, S, Chasman, DI, Rotter, JI, Meigs, JB, Florez, JC, Dupuis, J, Liu, CT, Merino, J. 01/01/2022. Diabetes Care. 45. PMID: 34789503. doi: 10.2337/dc21-1284

    HTE 3.0: Knowledge-based systems in cascade for familial hypercholesterolemia detection and dyslipidemia treatment

    López, B, Torrent-Fontbona, F, Marín, LM, Zamora, A. 01/01/2022. Expert Systems. 39. doi: 10.1111/exsy.12835

    SEA 2022 Standards for Global Control of Cardiovascular Risk

    Mostaza, JM, Pinto, X, Armario, P, Masana, L, Real, JT, Valdivielso, P, Arrobas-Velilla, T, Baeza-Trinidad, R, Calmarza, P, Cebollada, J, Civera-Andres, M, Melero, JIC, Diaz-Diaz, JL, Pardo, JF, Guijarro, C, Jerico, C, Laclaustra, M, Lahoz, C, Lopez-Miranda, J, Martinez-Hervas, S, Muniz-Grijalvo, O, Paramo, JA, Pascual, V, Pedro-Botet, J, Perez-Martinez, P, Plana, N, Puzo, J, Chaparro, MAS, Vila, L. 01/05/2022. CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS. 34. PMID: 35090775. doi: 10.1016/j.arteri.2021.11.003

Membres De L’equip

Altres grups de Malalties Metabòliques i Nutrició

Veure tots