IRB CatSud hosted a training session on June 11, focused on updating the new MRI equipment of the Clinical Research Unit (UiC). This activity allowed to publicize the technical characteristics of this infrastructure and its applications in the development of clinical studies.
The training was aimed at research staff, health professionals and research support teams, and combined theoretical content with the analysis of practical cases linked to the field of biomedical research. The session was given by the medical imaging specialist Gerard Blasco Solà, with experience in clinical applications and training in magnetic resonance, who shared applied knowledge about the possibilities of this advanced equipment.
With this initiative, IRB CatSud reinforced the training of professionals in the territory and promoted the use of cutting-edge technologies to promote the development of new clinical research projects.
Around sixty researchers from all over the country, from both basic and clinical research fields, have participated in the first national conference on genetics in psychiatry, held in Reus this Wednesday and organized by the Hospital Universitari Institut Pere Mata (HUIPM) and the Institut de Recerca Biomèdica Catalunya Sud (IRB CatSud), with the participation of the CIBERSAM network (Centro de Investigación Biomédica en Red en Salud Mental). One of the main achievements of the meeting, held at the HUIPM facilities, has been the promotion of a shared proposal to create a stable network or working group in genetics in psychiatry, with a long-term vision and with the aim that it may evolve into a future scientific society.
During the conference, strategic lines were discussed, such as promoting collaborative work, sharing data and knowledge, or creating a repository of genetic data, as well as the need to strengthen the transfer of results to clinical practice and society.
The meeting has represented a turning point in the field of genetics in psychiatry, since until now researchers specialised in the genetics of psychiatric disorders in the country had never met in a specific forum. In recent years, the growth of research in this field and the emergence of results with potential clinical application have favoured the consolidation of a critical mass that has made it possible to promote this initiative.
“It is the first conference held by specialist researchers in genetics of psychiatric diseases, and the reason is that it is a relatively innovative field. Over the years, the researchers we met at conferences said we had to do something together and, at the end of last October, at an international psychiatric genetics conference in Mexico, we decided to do it and chose to hold the first conference in Reus,” said the research director of HUIPM and deputy director of IRB CatSud, Elisabet Vilella.
At the conference, the different participating teams also shared their lines of work and presented the latest advances in genetics in psychiatry, with the aim of generating synergies and exploring new ways of collaboration. “Our group presented work related to the development and characterisation of neuronal lines from patients with first psychotic episodes, where we look for biological signals to help find the best diagnosis so that there can be the most personalised treatment possible, for example in the development of schizophrenia,” explained the researcher from the Instituto de Investigación Sanitaria de Valencia (INCLIVA), Ricardo Ruiz Miguel, one of the speakers at the conference.
The organisers also highlighted that initiatives like this help to accelerate the transfer of scientific knowledge into real applications and to promote collaboration between research groups, also incorporating work with patient associations as one of the key axes for the future.
With this first edition, the conference has laid the foundations to become a regular reference meeting at the national level, with the intention of continuing to strengthen scientific cooperation and to increase the impact of research in mental health for the benefit of society.
▪ This is the first event of this kind in Spain and it will be held on 17 June at the Pere Mata University Hospital
▪ The national mental health research network, CIBERSAM, is also involved in organising the event
Sharing knowledge, exchanging research lines and promoting new scientific collaborations are the main goals of the first national workshop on genetics in psychiatry. The event will take place at the Pere Mata University Hospital and will bring together research groups from across Spain specialised in the genetics of psychiatric disorders.
The meeting, which will be held on 17 June, will gather highly competitive research groups at an international level. Most of them are part of the CIBERSAM network (Biomedical Research Networking Center in Mental Health), funded by the Carlos III Health Institute, and of the international consortium Psychiatric Genomics Consortium.
The workshop has been designed with a dynamic and participatory format. It will combine short presentations from the different teams, where they will present their structure, objectives and research lines. In addition, there will be workshops aimed at identifying common priorities and opportunities for joint work. The latest advances in genetics in psychiatry achieved by national groups will also be presented.
One of the key elements of the workshop will be the collective development of future proposals, including the possible creation of a stable network or working group on genetics in psychiatry. It will also promote shared initiatives in areas such as translational research and knowledge transfer to clinical practice and society.
Genetics in psychiatry is a field that has experienced a real expansion of knowledge in recent years, driven by advances in genomic technologies and the analysis of large data sets. These developments have made it possible to identify genetic variants associated with disorders such as schizophrenia, bipolar disorder or autism, improving the understanding of their biological basis and opening the door to more precise and personalised strategies for prevention and treatment.
With this first edition, the organisers aim to establish the basis for a regular reference meeting that will help strengthen collaboration between research groups and increase the impact of mental health research. Here, the programme.
A study by IRB Catalunya Sud (formerly IISPV) and Hospital Universitari Joan XXIII de Tarragona has discovered that these vesicles act differently depending on tumour aggressiveness, opening new possibilities for future therapeutic strategies.
Prostate cancer is the most common tumour in men in many Western countries. In the Tarragona region, nearly 670 new cases are diagnosed each year, and the number exceeds 30,000 at the national level. Although many tumours grow slowly, others can progress and spread, so understanding the factors that drive this aggressiveness is essential to improve patient outcomes.
In this context, researchers from the Grup de Recerca en Biomarcadors de Malalties i Mecanismes Moleculars (DIBIOMEC) at the Institut de Recerca Biomèdica Catalunya Sud (IRB Catalunya Sud, formerly IISPV), in collaboration with the Urology and Pathology Departments of Hospital Universitari Joan XXIII de Tarragona, have made an important step forward. Their recently published study shows for the first time that extracellular vesicles (small particles released by cells) from the adipose tissue surrounding the prostate (periprostatic adipose tissue, PPAT) modulate the behaviour of tumour cells differently depending on cancer risk level.
The research, led by Dra. Matilde R. Chacón and Dr. Xavier Ruiz-Plazas, and carried out by a multidisciplinary team, provides a new perspective on how the tumour microenvironment — particularly periprostatic fat — “communicates” with cancer and influences its evolution.
First, the study reveals risk‑dependent effects. Vesicles from periprostatic adipose tissue of patients with low‑risk prostate cancer mainly stimulate tumour cell proliferation. In contrast, vesicles from patients with high‑risk tumours do not promote proliferation, but they do increase the migration capacity of cancer cells and stimulate angiogenesis (the formation of new blood vessels), both of which are key processes in tumour progression and spread.
The vesicles also affect the tumour microenvironment. Besides acting on cancer cells, they influence other surrounding cells. Low‑risk vesicles promote a pro‑inflammatory and immunosuppressive profile in macrophages (immune cells), which may help create a supportive environment for early‑stage tumours.
Another important finding is the activation of signalling pathways, as the observed effects are linked to the activation of key molecular routes in cancer.
This discovery shows that periprostatic adipose tissue is not just a passive structure but an active and dynamic player that modulates prostate cancer behaviour depending on disease aggressiveness. Extracellular vesicles from this tissue emerge as promising therapeutic targets for future strategies aimed at interfering with communication between the tumour and its microenvironment, especially in cases with a higher risk of progression.
Although these results come from in vitro models and further studies will be needed in more complex systems, this research represents a significant step forward in understanding prostate cancer biology and opens a promising avenue for translational research.
Link to the scientific publication:
Arreaza-Gil V. et al. Periprostatic adipose tissue-derived extracellular vesicles modulate prostate cancer cell behaviour in vitro according to tumour grade. Mol Med (2026).
PubMed: https://pubmed.ncbi.nlm.nih.gov/41566212/
DOI: 10.1186/s10020-026-01422-7
The students had the opportunity to learn first-hand how biomedical research is carried out and to discover the role of professionals who work to improve people’s health
The Pere Virgili Institute for Health Research (IISPV) welcomed, this Friday 6 February, a group of students from the Mare de Déu del Carme School in Tarragona to its facilities located at the Sant Joan University Hospital in Reus.
During the visit, the students were able to see directly how biomedical research is developed, explore different working areas and discover the work of professionals who research to improve public health. The activity aimed to bring science and research closer to young people and to inspire scientific interest.
This initiative is part of the IISPV’s commitment to scientific outreach and education, through activities designed for both schools and the general public. In this sense, the Institute promotes guided visits and outreach actions throughout the year to share its research work.
Among other important initiatives, last year the IISPV organised, on the occasion of its 20th anniversary, the event “Health research goes to the streets” in Reus and Tarragona, with workshops and activities specially created for children and teenagers, with the goal of explaining science in a simple and engaging way.
With actions like this school visit, the IISPV strengthens its commitment to connecting biomedical research with society and contributing to the scientific education of future generations.
The Institut d’Investigació Sanitària Pere Virgili (IISPV) and La Lliga Contra el Càncer de les Comarques de Tarragona i Terres de l’Ebre have signed a framework agreement that strengthens the commitment of both institutions to research, prevention and public awareness in the field of health and the fight against cancer. The signing takes place on the eve of World Cancer Day, which is celebrated tomorrow, 4 February, a day that highlights the importance of joining efforts to reduce the impact of this disease on society.
The agreement creates a stable cooperation framework lasting four years, renewable annually for another four years. This will allow the development of research projects and activities aimed at improving the health and quality of life of people affected by this disease. In this context, La Lliga will provide yearly financial support to the IISPV for research projects and cancer prevention initiatives. The first planned contribution is 68,000 euros.
Joan Vendrell, director of the IISPV, stated that this collaboration “is an opportunity to strengthen cancer research carried out in our territory and to move forward with projects that have a direct impact on people’s health”. He added that “working together with an organisation with such a strong background in prevention and awareness, like La Lliga Contra el Càncer, allows us to make significant progress in the cancer research we do at our Institut”.
On the other hand, Agustina Sirgo, president of La Lliga Contra el Càncer de les Comarques de Tarragona i Terres de l’Ebre, emphasised that “research is one of the most powerful tools to improve the lives of people living with cancer. This agreement helps us join forces with a leading centre like the IISPV and ensures that the support of local citizens becomes progress that directly benefits the patients in our counties. Supporting research is a responsibility we take on with pride and determination. We want every patient and every family to know that they are not alone, and that we will continue working so that the future can be better.”
The alliance between the two institutions also includes public awareness actions aimed at fostering healthy habits and promoting early detection, which is one of the key factors in improving cancer survival.
A study led by the Diabetes and Associated Metabolic Diseases (DIAMET) group at the Institut de Recerca Biomèdica Catalunya Sud (IRB CatSud, formerly IISPV) shows that liver fibrosis and type 2 diabetes significantly modify the hormonal response after eating in people with fatty liver associated with metabolic dysfunction (MASLD). The research, published in the Journal of Physiology and Biochemistry, examines how both conditions affect the secretion of essential hormones for glucose control—such as glucagon and the incretins (GLP‑1, GLP‑2 and GIP)—after a standardized meal.
The results show that liver fibrosis is the most important factor influencing the increase in GLP‑1 levels, both in fasting conditions and after the meal, regardless of whether the patient has diabetes. In addition, when liver fibrosis and type 2 diabetes occur together, hormonal changes become stronger, suggesting a synergistic effect between both conditions. Type 2 diabetes is also linked to the loss of the normal suppression of glucagon after eating, a key process to keep blood glucose within healthy ranges.
These findings reinforce the idea that a fibrotic liver is not a passive organ, but plays an active role in metabolic dysregulation. Fibrosis not only reflects past damage but also contributes to generating new hormonal alterations. Understanding these changes is essential to improve clinical assessment and move towards more personalised treatments for MASLD.
With the growing prevalence of MASLD and type 2 diabetes, understanding how these conditions interact at the hormonal level is crucial to improve early diagnosis and optimise treatments based on the incretin–glucagon axis. The study provides evidence that can help identify subgroups of patients who may benefit from more specific therapeutic approaches, with a direct impact on clinical practice.
Overall, the results confirm that liver fibrosis is a central determinant of GLP‑1 levels, and that the coexistence of type 2 diabetes further intensifies these hormonal alterations. This knowledge highlights the need to design therapeutic strategies adapted to the metabolic and liver profile of each patient, especially in a context where both diseases are becoming increasingly common.
The study involved researchers from the Universitat Rovira i Virgili (URV), the Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) – Hospital Clínic Barcelona, the research networks of the Instituto de Salud Carlos III (ISCIII) — the Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) and the Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) — as well as the Hospital Universitari Joan XXIII (Tarragona).
A collaborative study from CIBERDEM-ISCIII shows that abdominal fat speeds up vascular ageing and increases the risk of long-term vascular complications, even before obesity appears.
A research team from the Parc Taulí Research and Innovation Institute (I3PT), together with the Pere Virgili Health Research Institute (IISPV) and the Hospital del Mar Research Institute (IMIM), has identified a clear link between abdominal fat accumulation and early vascular ageing in people with type 1 diabetes who have no previous cardiovascular disease.
The study was carried out with a group of 179 people with this condition, all evaluated at Parc Taulí University Hospital under the coordination of José Miguel González-Clemente, endocrinologist and head of the diabetes–cardiovascular risk group at I3PT, and Joan Vendrell, IISPV researcher, co-leader of the DIAMET research group and member of CIBERDEM-ISCIII.
Even though the participants had good control of blood glucose, blood pressure and lipid levels, around 10% showed signs of early vascular ageing. This is an important factor in the development of cardiovascular and microvascular complications that directly affect quality of life and life expectancy.
“In type 1 diabetes, insulin treatment is essential to control blood glucose, but over the years it can lead to gradual weight gain and a higher risk of complications,” González-Clemente explains. He adds that abdominal fat can accumulate before general obesity appears, especially visceral fat, which is metabolically active and strongly linked to artery damage. “This type of fat reduces arterial elasticity, a process related to the degradation of elastin, a key protein in the vascular wall. It may contribute to complications such as heart attack, stroke, circulation problems in the legs, or damage to the retina, kidneys and peripheral nerves.”
The waist-to-height ratio, a tool to detect early vascular ageing
To easily identify people at higher risk, the study highlights the waist-to-height ratio, calculated by dividing waist circumference by height, both in centimetres. The results show that a value of 0.56 or higher is linked to accelerated vascular ageing, measured through pulse wave velocity, a non-invasive technique that assesses arterial stiffness. “Almost all people with high pulse wave velocity had a waist-to-height ratio of 0.56 or more,” González-Clemente notes, adding that other common indicators, such as body mass index or waist-to-hip ratio, are less effective at detecting this risk.
The findings, published in Diabetes Research and Clinical Practice, underline the importance of preventing weight gain and monitoring abdominal fat as a preventive strategy. “Early control of this index would allow intervention before obesity develops, improve metabolic control and reduce the risk of long-term vascular complications,” he concludes.
The researchers point out that the next step is to confirm these results in larger cohorts with longer follow-up. The study also suggests that some drugs used in people with type 2 diabetes to reduce weight might also be useful in type 1 diabetes, although more clinical evidence is still needed.
A study of 746 older people followed for six years identifies a “microbial signature” associated with this dietary pattern and more favourable cognitive ageing
Following a Mediterranean diet not only benefits the heart and metabolism, but could also help preserve cognitive function as ageing progresses. This is according to research led by the Rovira i Virgili University (URV), the IISPV and CIBERobn, which shows how this dietary pattern is associated with a healthier gut microbiota and slower cognitive decline in older adults with overweight or obesity and metabolic syndrome.
The study, published in the journal BMC Medicine, analysed data from 746 older adults at high cardiometabolic risk, who were followed for six years. The research team assessed adherence to the Mediterranean diet, the composition of the gut microbiota and the progression of cognitive function over time. The results indicate that those who most faithfully followed this dietary pattern had a more favourable gut microbiota and a more positive cognitive trajectory.
One of the most innovative aspects of the work is the identification of a “microbial fingerprint” characteristic of the Mediterranean diet. This new biomarker, based on the presence and abundance of certain gut bacteria associated with this type of diet, is also linked to slower cognitive decline. According to the authors, this finding provides new clues about the biological mechanisms that explain the benefits of the Mediterranean diet on the brain.
Eix intestí-cervell
Cognitive function includes abilities such as memory, attention, learning, language and decision-making, which are essential for maintaining autonomy in everyday life. In parallel, the gut microbiota is composed of trillions of bacteria that are involved in key processes such as digestion, immunity and the production of substances that influence the body’s functioning. In recent years, research has revealed the existence of the so-called gut-brain axis, a bidirectional communication system through which intestinal microorganisms can produce compounds that reach the brain and affect its functioning.
“Aquest estudi demostra que la microbiota intestinal és una peça clau en els beneficis cognitius de la dieta mediterrània”, explica Jiaqi Ni, primera autora del treball i investigadora predoctoral de la URV. “Els nostres resultats suggereixen que alguns bacteris intestinals associats a una major adherència a aquest patró alimentari podrien protegir davant del deteriorament cognitiu”.
En la mateixa línia, el catedràtic de la URV Jordi Salas-Salvadó, director de l’estudi, destaca que “identificar una empremta microbiana associada a la dieta mediterrània obre noves oportunitats per dissenyar intervencions nutricionals o microbianes orientades a promoure un envelliment cognitiu saludable”. De la seva banda, les investigadores del Departament de Bioquímica i Biotecnologia de la URV Nancy Babio i Stephanie K. Nishi subratllen la rellevància dels resultats en un context d’envelliment poblacional i augment de la prevalença de la demència, i apunten que millorar la qualitat de la dieta és una estratègia senzilla i accessible amb beneficis reals per a la salut cerebral.
El treball ha estat liderat per la investigadora predoctoral Jiaqi Ni i dirigit per Jordi Salas-Salvadó, Nancy Babio i Stephanie K. Nishi, membres de la Unitat de Nutrició Humana del Departament de Bioquímica i Biotecnologia de la URV, amb la col·laboració d’investigadors del consorci PREDIMED-Plus. L’estudi s’emmarca en una recerca multicèntrica que contribueix a aprofundir en la relació entre alimentació, microbiota intestinal i salut cerebral al llarg de l’envelliment.
Referència bibliogràfica: Ni J, Hernández-Cacho A, Nishi SK, Babio N, Belzer C, Konstati P, Vioque J, Corella D, Castañer O, Vidal J, Moreno-Indias I, Torres-Collado L, Coltell O, Fitó M, Ruiz-Canela M, Wang DD, Tinahones FJ, Salas-Salvadó J. Mediterranean diet, gut microbiota, and cognitive decline in older adults with obesity/overweight and metabolic syndrome: a prospective cohort study. BMC Med. 2025 Dec 1;23(1):669. doi: 10.1186/s12916-025-04488-y.
Maternal nutrition is essential for babies’ cognitive development, but some nutrients have received less attention in scientific research. Vitamin K, mainly known for its role in blood clotting, is one example. Although it is found in leafy green vegetables and vegetable oils, and is involved in processes related to glucose metabolism, insulin, and antioxidant and anti-inflammatory activity, its possible influence on children’s neurological development had not been explored until now.
A new study led by teams from the Universitat Rovira i Virgili (URV) and IRB CatSud (formerly IISPV), in collaboration with ISGlobal, provides the first evidence linking maternal intake of vitamin K1 (phylloquinone) with children’s neurodevelopment.
The research was directed by Mònica Bulló, head of the Nutrition and Metabolic Health group at URV and the TecnATox research center, and by Jordi Júlvez, researcher at IRB CatSud. The results have been published in the scientific journal Pediatric Research.
The study analysed 1,080 pregnant women and their children from the BiSC cohort. To estimate vitamin K intake, participants completed a food frequency questionnaire with 114 items. Later, several areas of early childhood neurodevelopment —cognition, socioemotional and physical development, communication, and behaviour— were evaluated at different stages.
The data show that higher vitamin K intake during pregnancy is associated with better overall development in children, as well as specific improvements in cognitive abilities and physical development. The study also suggests that doubling the current vitamin K recommendations for the general population could be linked to better communication skills and expressive language. Although this is an observational study and cannot prove direct causality, the research team believes it opens new paths to deepen our understanding of the role of maternal nutrition in neurocognitive development.
“The evidence we found suggests that vitamin K may play a beneficial role, and this could lead to future dietary recommendations specifically for pregnant women, with the aim of promoting optimal cognitive development in early childhood,” explains URV professor Mònica Bulló.
Bibliographic reference:
Mateu-Fabregat, J., Panisello, L., Novau-Ferré, N. et al. Maternal dietary phylloquinone intake (vitamin K1) and early childhood neurodevelopment. Pediatr Res (2025). https://doi.org/10.1038/s41390-025-04543-7
