Around sixty researchers from all over the country, from both basic and clinical research fields, have participated in the first national conference on genetics in psychiatry, held in Reus this Wednesday and organized by the Hospital Universitari Institut Pere Mata (HUIPM) and the Institut de Recerca Biomèdica Catalunya Sud (IRB CatSud), with the participation of the CIBERSAM network (Centro de Investigación Biomédica en Red en Salud Mental). One of the main achievements of the meeting, held at the HUIPM facilities, has been the promotion of a shared proposal to create a stable network or working group in genetics in psychiatry, with a long-term vision and with the aim that it may evolve into a future scientific society.

During the conference, strategic lines were discussed, such as promoting collaborative work, sharing data and knowledge, or creating a repository of genetic data, as well as the need to strengthen the transfer of results to clinical practice and society.

The meeting has represented a turning point in the field of genetics in psychiatry, since until now researchers specialised in the genetics of psychiatric disorders in the country had never met in a specific forum. In recent years, the growth of research in this field and the emergence of results with potential clinical application have favoured the consolidation of a critical mass that has made it possible to promote this initiative.

“It is the first conference held by specialist researchers in genetics of psychiatric diseases, and the reason is that it is a relatively innovative field. Over the years, the researchers we met at conferences said we had to do something together and, at the end of last October, at an international psychiatric genetics conference in Mexico, we decided to do it and chose to hold the first conference in Reus,” said the research director of HUIPM and deputy director of IRB CatSud, Elisabet Vilella.

At the conference, the different participating teams also shared their lines of work and presented the latest advances in genetics in psychiatry, with the aim of generating synergies and exploring new ways of collaboration. “Our group presented work related to the development and characterisation of neuronal lines from patients with first psychotic episodes, where we look for biological signals to help find the best diagnosis so that there can be the most personalised treatment possible, for example in the development of schizophrenia,” explained the researcher from the Instituto de Investigación Sanitaria de Valencia (INCLIVA), Ricardo Ruiz Miguel, one of the speakers at the conference.

The organisers also highlighted that initiatives like this help to accelerate the transfer of scientific knowledge into real applications and to promote collaboration between research groups, also incorporating work with patient associations as one of the key axes for the future.

With this first edition, the conference has laid the foundations to become a regular reference meeting at the national level, with the intention of continuing to strengthen scientific cooperation and to increase the impact of research in mental health for the benefit of society.

▪ This is the first event of this kind in Spain and it will be held on 17 June at the Pere Mata University Hospital

▪ The national mental health research network, CIBERSAM, is also involved in organising the event

Sharing knowledge, exchanging research lines and promoting new scientific collaborations are the main goals of the first national workshop on genetics in psychiatry. The event will take place at the Pere Mata University Hospital and will bring together research groups from across Spain specialised in the genetics of psychiatric disorders.

The meeting, which will be held on 17 June, will gather highly competitive research groups at an international level. Most of them are part of the CIBERSAM network (Biomedical Research Networking Center in Mental Health), funded by the Carlos III Health Institute, and of the international consortium Psychiatric Genomics Consortium.

The workshop has been designed with a dynamic and participatory format. It will combine short presentations from the different teams, where they will present their structure, objectives and research lines. In addition, there will be workshops aimed at identifying common priorities and opportunities for joint work. The latest advances in genetics in psychiatry achieved by national groups will also be presented.

One of the key elements of the workshop will be the collective development of future proposals, including the possible creation of a stable network or working group on genetics in psychiatry. It will also promote shared initiatives in areas such as translational research and knowledge transfer to clinical practice and society.

Genetics in psychiatry is a field that has experienced a real expansion of knowledge in recent years, driven by advances in genomic technologies and the analysis of large data sets. These developments have made it possible to identify genetic variants associated with disorders such as schizophrenia, bipolar disorder or autism, improving the understanding of their biological basis and opening the door to more precise and personalised strategies for prevention and treatment.

With this first edition, the organisers aim to establish the basis for a regular reference meeting that will help strengthen collaboration between research groups and increase the impact of mental health research. Here, the programme.

A study involving more than 1,500 patients is analysing genetic variants linked to psychiatric disorders and exploring tools to help psychiatrists identify patients with a possible genetic origin of their condition. This work is part of the CESPED project, coordinated by Hospital Universitari Institut Pere Mata (HUIPM) and the Institut de Recerca Biomèdica Catalunya Sud (IRB CatSud, formerly IISPV). The project has a budget of €1.7 million funded by the Instituto de Salud Carlos III (ISCIII) through the European Union’s Recovery and Resilience Facility. In addition, 17 Spanish research groups have participated, including 12 from CIBERSAM. Preliminary results show a frequency close to 3% of microdeletions and microduplications -losses or gains of genetic material- in the Spanish population, which is similar to international studies. The test used combines clinical information, such as psychiatric diagnosis, and also analyses facial features. At present, researchers are still analysing the data and final results are not yet available. However, the study coordinator, Elisabet Vilella -also deputy director of IRB CatSud and head of the Neuroscience and Mental Health area- is optimistic. She explains that “the first results suggest that the frequency of these genetic variants in Spain is around 3%, similar to what has been reported in other countries”. The CESPED project started in 2023 and recently held its final meeting in Barcelona. It was developed in response to growing knowledge about the role of genetics in psychiatric disorders, especially neurodevelopmental conditions. Because these cases are difficult to identify in daily clinical practice, the project aims to develop tools to help professionals detect patients who may have a genetic basis and guide further testing. The research shows that a large part of psychiatric disorders has a genetic component, which can be up to 80% in neurodevelopmental disorders such as autism, ADHD or psychosis. It also shows that between 2% and 5% of patients carry genetic variants caused by gains or losses of genetic material, which may explain the disorder. These changes often affect several genes and organs and can lead to multi-system conditions known as syndromes. For psychiatrists, it is difficult to recognise these cases during a consultation. For this reason, within the CESPED project, a test has been developed to collect key information, such as diagnosis, age of onset, developmental issues, intellectual disability or resistance to treatment. The test also includes a facial photograph to identify specific physical features. The sample The 14 research groups involved in recruitment worked for two years to obtain a sample of 1,555 patients: 471 children and 1,084 adults. Diagnoses include autism spectrum disorder, ADHD, schizophrenia and other psychoses, and bipolar disorder type 1. Different techniques are used to detect genetic variants. Each participant will receive a report, and those with identified genetic changes will be advised to visit a clinical genetics unit for further evaluation. Este proyecto está financiado por el Instituto de Salud Carlos III (ISCIII), la Unión Europea-NextGenerationEU y el Plan de Recuperación Transformación y Resiliencia (PRTR), con el código PMP22/00088.